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SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol.
Jiang AK, Arp G, Kato M, Brunner T, Grant MR, Clarke AM, Sidebottom AM, McMillin M, Lehmann CJ, Odenwald MA, Wolfe KS, Patel BK, Odenike O, Li Y, Light SH, Hall B, Jiang X

SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol.

Medicine & Health Published 2026 Verification Pending

Overview & Synopsis

Open access biomedical research article published in bioRxiv.

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Indexed from repository: PubMed Central (pmc.ncbi.nlm.nih.gov)
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Document Title SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol.
Author / Organization Jiang AK, Arp G, Kato M, Brunner T, Grant MR, Clarke AM, Sidebottom AM, McMillin M, Lehmann CJ, Odenwald MA, Wolfe KS, Patel BK, Odenike O, Li Y, Light SH, Hall B, Jiang X
Subject & Discipline bioRxiv
Categories Medicine & Health
Publication Year 2026
License / Rights Open Access / Creative Commons
Resource Verification Listed PDF (Verification Pending)
Original Host Website PubMed Central (pmc.ncbi.nlm.nih.gov)
File Format application/pdf (Portable Document Format)
Language EN
Catalog ID DOC-18453
Original Source Link Visit Source Page on pmc.ncbi.nlm.nih.gov »