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CRISPR-Cas9 is a promising technology for gene therapy. However, the ON-target genotoxicity of CRISPR-Cas9 nuclease due to DNA double-strand breaks has received little attention and is probably underestimated. Here we re...
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L’objectif de ce travail a été d’étudier la génotoxicité de la thérapie génique par CRISPR (Clustered Regularly Interspaced Palindromic Repeats)-Cas9 (CRISPR associated protein) et de proposer une sécurisation dans des m...