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It has been shown that a novel 4 parameter model (IC 50 =ΔG desolvation free energy of water + lipophilicity + dipole moment + molecular volume) applies to a broad range of PARP1 and PARP2 inhibitory activity. Similarly ...
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Highlights: • Statins in vitro and in vivo anti-cancer efficacy • Statin-HMG-CoA reductase inhibition • Statin cellular influx transport • Quantitative structure activity relationships • Statins, cyclin-dependent kinases...