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Role of pyroptosis in spinal cord injury and its therapeutic implications

Abdullah Al Mamun, Yanqing Wu, Ilma Monalisa, Chang Jia et al. • Journal of Advanced Research (2021)

Background: Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosi...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jare.2020.08.004

Fumaric acid regulates morphine tolerance in bone cancer pain through spinal MrgC receptor modulation

Sijie Liu, Minghao Tang, Jing Zhao, Lulu Zhang et al. • Pakistan Journal of Pharmaceutical Sciences (2026)

Background: Bone cancer pain (BCP) represents a debilitating complication that profoundly impacts patient quality of life and predisposes to psychological comorbidities, including depression and anxiety. Objectives: To investigate the effec...

DOAJ Open Access (DOAJ) DOI: 10.36721/PJPS.2026.39.8.233.1

Non-traumatic Causes of Brown-sequard Syndrome: A Case Series and Clinical Update With Systematic Review

Vaner Köksal, Mahmoud Osama, Mohammed Ali Alvi • Iranian Journal of Neurosurgery (2021)

Background and Importance: Brown-Sequard Syndrome (BSS) is a rare neurological condition resulting from a hemisection injury to or unilateral compression on the spinal cord. The common causes of BSS that are amenable to be treated surgicall...

DOAJ Open Access (DOAJ)

Bone turnover markers and parameters of functional and structural state in patients with chronic spinal cord injuries in 5 years and later after the trauma

M.A. Bystrytska, V.V. Povoroznyuk • Bolʹ, Sustavy, Pozvonočnik (2017)

Актуальность. Увеличение продолжительности жизни пациентов с травмой позвоночника и спинного мозга (ТПСМ) привлекло внимание к поздним осложнениям ТПСМ, в частности к остеопорозу. Цель исследования — оценить структурно-функциональное состоя...

DOAJ Open Access (DOAJ) DOI: 10.22141/2224-1507.7.2.2017.108700

Types of Skin Afferent Fibers and Spinal Opioid Receptors that Contribute to Touch-Induced Inhibition of Heart Rate Changes Evoked by Noxious Cutaneous Heat Stimulation

Nobuhiro Watanabe, Mathieu Piché, Harumi Hotta • Molecular Pain (2015)

Background In anesthetized rats and conscious humans, a gentle touch using a soft disc covered with microcones (with a texture similar to that of a finger), but not with a flat disc, inhibits nociceptive somatocardiac reflexes. Such an inhi...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12990-015-0001-x

Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation

Akihiro Sugai, Taisuke Kato, Akihide Koyama, Yuka Koike et al. • Neurobiology of Disease (2019)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by accumulation of fragmented insoluble TDP-43 and loss of TDP-43 from the nucleus. Increased expression of exogenous TARDBP (encoding TDP-43) induces TDP-43 p...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nbd.2019.104534

Neuroscience in Medicine

P. Michael Conn • Humana Press eBooks (2003)

Cytology and Organization of Cell Types: Light and Electron Microscopy Rochelle S. Cohen and Donald W. Pfaff Anatomy of the Spinal Cord and Brain Bruce E. Maley Ion Channels and Electrical Signaling Stanko S. Stojilkovic A. Clinical Correla...

OPENALEX DOI: https://doi.org/10.1007/978-1-59259-371-2

NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury

Yan Lin, Chunhong Li, Jian Li, Ruolan Deng et al. • Journal of Nanobiotechnology (2019)

Abstract Background Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes an...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-019-0449-3

Protective effects of ceria nanoclusters against delayed paraplegia after spinal cord ischemia

Wang Yang, Ling Zou, Qianqian Wu, Lu Yang et al. • Journal of Materials Science: Materials in Medicine (2026)

Abstract Spinal cord ischemia reperfusion injury (SCIRI) induced delayed paraplegia is a complex complication of thoracoabdominal aortic surgery. Reactive oxygen species (ROS) play a critical role in the pathogenesis of delayed paraplegia, ...

DOAJ Open Access (DOAJ) DOI: 10.1007/s10856-026-07062-x

Induced Pluripotent Stem Cells (iPSCs)—Roles in Regenerative Therapies, Disease Modelling and Drug Screening

Mourad A. M. Aboul-Soud, Alhusain J. Alzahrani, Amer Mahmoud • Cells (2021)

The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution to the field of regenerative medicine, paving way for identifying the true potential of human embryonic stem cells (ESCs). Since the controversy aro...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells10092319

Virtual CT Myelography: A Patch-Based Machine Learning Model to Improve Intraspinal Soft Tissue Visualization on Unenhanced Dual-Energy Lumbar Spine CT

Xuan V. Nguyen, Devi D. Nelakurti, Engin Dikici, Sema Candemir et al. • Information (2022)

Background: Distinguishing between the spinal cord and cerebrospinal fluid (CSF) non-invasively on CT is challenging due to their similar mass densities. We hypothesize that patch-based machine learning applied to dual-energy CT can accurat...

DOAJ Open Access (DOAJ) DOI: 10.3390/info13090412