Academic Articles & Research Papers

Generation Scotland: Linking all the records we can

Objectives We started a family-based genetic epidemiology study in 2006-11 which recruited ~24,000 adult volunteers from ~7000 families across Scotland with consent for follow-up through medical record linkage and re-contact. In 2022-23 we ...

Screening of serum biomarkers for coronary artery calcification using DIA quantitative proteomics and construction of a regression model.

Pan-modification proteomics: decoding tumor heterogeneity and guiding the next generation of precision oncology.

Large-scale plasma proteomics identifies proteins and pathways associated with incident interstitial lung disease.

Integrating proteomics to map immune landscape and protein biomarkers for risk stratification in childhood Langerhans cell histiocytosis.

Proteomic insights in sepsis: advancing diagnosis, therapeutic targets, and the path to precision medicine.

Population proteomics for equitable precision medicine.

Integrated proteomics and metabolomics for predicting cardiometabolic risk in pregnant women living with HIV: current evidence and future directions.

Bi-hourly plasma proteomics during the first 48 h of life in an African cohort reveals distinct periods and sex-dependent immune development.

Stress-dependent ribosome-associated proteomics reveals a role for Sis1 in thermotolerance and virulence in Cryptococcus neoformans.

Genetics : a conceptual approach

Introduction to Genetics Genetics Is Important to Us Individually, to Society, and to the Study of Biology Humans Have Been Using Genetics for Thousands of Years A Few Fundamental Concepts Are Important for the Start of Our Journey into Gen...

Microbial Electrosynthesis Reshapes Energy Metabolism and Physiology in Clostridium ljungdahlii

ABSTRACT Microbial electrosynthesis (MES) enables a variety of microorganisms, particularly acetogens, to utilize electrical energy in the form of electrons to produce valuable compounds from CO2. In the closely related process of gas ferme...

Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19

Abstract Although brain alterations have been reported in post-acute sequelae of SARS-CoV-2 (PASC), their prevalence and relationship to neurodegeneration remain unclear. We analyzed blood proteins and brain MRI from individuals approximate...

Revisiting Hyaluronan Catabolism in Bacteroides: Pathway Conservation, Overlooked Proteins, and Predictive Accuracy

ABSTRACT The ability of gut microbes to degrade host‐ and diet‐derived glycans is central to microbiome ecology and host interactions, yet predicting these functions in silico remains challenging. Hyaluronan (HA), a glycosaminoglycan (GAG) ...

Bone Diagenesis in Short Timescales: Insights from an Exploratory Proteomic Analysis

The evaluation of bone diagenetic phenomena in archaeological timescales has a long history; however, little is known about the origins of the microbes driving bone diagenesis, nor about the extent of bone diagenesis in short timeframes—suc...

Advances in High Throughput Proteomics Profiling in Establishing Potential Biomarkers for Gastrointestinal Cancer

Gastrointestinal cancers (GICs) remain the most diagnosed cancers and accounted for the highest cancer-related death globally. The prognosis and treatment outcomes of many GICs are poor because most of the cases are diagnosed in advanced me...

From BIG Data Center to China National Center for Bioinformation

LocateP: Genome-scale subcellular-location predictor for bacterial proteins

Abstract Background In the past decades, various protein subcellular-location (SCL) predictors have been developed. Most of these predictors, like TMHMM 2.0, SignalP 3.0, PrediSi and Phobius, aim at the identification of one or a few SCLs, ...

Computational Tools; Indispensable Armamentarium of Medical Biotechnology

Objective: Computational infrastructure of medical biotechnology provides insight into elements of genomics, proteomics for understanding diseases and biological systems in a more comprehensive and systematic way. The present study exclusiv...

Molecular Biology and Biotechnology

One of the exciting aspects of being involved in the field of molecular biology is the ever-accelerating rate of progress, both in the development of new methodologies and the practical applications of these methodologies. This popular text...