Academic Articles & Research Papers

Highly Sensitive Dopamine Electrochemical Sensor Using Pt Nanoparticles on CNTs/Polypyrrole Nanocomposites

ABSTRACT Dopamine (DA) plays a vital role as a neurotransmitter in the central nervous system (CNS), and its accurate quantification is essential for diagnosing neurological disorders. However, selective and sensitive detection of DA in com...

Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect ...

Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

Activity-driven changes in the neuronal surface glycoproteome are known to occur with synapse formation, plasticity, and related diseases, but their mechanistic basis and significance are unclear. Here, we observed that N-glycans on surface...

Human cardiac innervation-on-a-chip platform recapitulates neurocardiac interactions and supports future disease modeling

Abstract The cardiac autonomic nervous system regulates cardiac function through innervation, and dysfunction of the neuronal and cardiovascular crosstalk has been linked to various pathologies. Here, we present a cardiac innervation-on-a-c...

Effects of chronic taurine administration on healthy pregnant rats and the consequences on the offspring: Datasets for motor tests and oxidative stress

We present the data for taurine (2-aminoethanesulfonic acid) treatment to healthy pregnant Sprague Dawley rats (SD). At embryonic day 15 (E15), healthy pregnant SD rats were given taurine treatment (50 mg/L drinking water) and then to their...

Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats

Prolonged or repeated exposure to stress elevates the risk of various psychological diseases, many of which are characterized by central nervous system dysfunction. Recent studies have demonstrated that circular RNAs (circRNAs) are highly a...

Autistic disorders and medical biotechnology.

chiefly described by three main deficits: 1) deviant communication, 2) impaired reciprocal social interaction, and 3) lim-ited, repetitive and stereotypic patterns of behaviors or interests 1. The world-wide prevalence of ADs is estimated t...

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury

Objectives and Aims: Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. An im...

Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior. Circadian clocks exist in almost every tissue and are thought to control tissue-spec...

Neurotransmitter-defined cerebral vulnerability patterns in frontotemporal lobar degeneration (FTLD).

Directed Evolution of Near-Infrared Serotonin Nanosensors with Machine Learning-Based Screening

In this study, we employed a novel approach to improve the serotonin-responsive ssDNA-wrapped single-walled carbon nanotube (ssDNA-SWCNT) nanosensors, combining directed evolution and machine learning-based prediction. Our iterative optimiz...