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Progressive suppression of regulated cell death defines terminal macrophage states in liver cirrhosis

Kepu Zheng, Leiyang Dai, Yanghui Wen, Haitao Jiang et al. • Annals of Medicine (2026)

Background Macrophages are central regulators of liver immunity and fibrosis; Recent single-cell studies have characterized macrophage heterogeneity in cirrhosis; however, how regulated cell death programs shape their functional transitions...

DOAJ Open Access (DOAJ) DOI: 10.1080/07853890.2026.2690717

Necroptosis and Neuroinflammation in Retinal Degeneration

Yan Tao, Yusuke Murakami, Demetrios G. Vavvas, Koh-Hei Sonoda • Frontiers in Neuroscience (2022)

Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2022.911430