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Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase

Nicholas J. Tobias, Tilman Ahrendt, Ursula Schell, Melissa Miltenberger et al. • PeerJ (2016)

Several members of the genus Legionella cause Legionnaires’ disease, a potentially debilitating form of pneumonia. Studies frequently focus on the abundant number of virulence factors present in this genus. However, what is often overlooked...

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.2720

Untargeted metabolomic profiling of Pseudocnella sykion from KwaZulu-Natal, South Africa using 1H-NMR and UPLC-QTOF-HR-MS

Cassandra Upton, Gerhard Prinsloo, Paul Anton Steenkamp, Moses Okpeku • Frontiers in Marine Science (2025)

IntroductionSea cucumbers are ecologically and economically significant marine invertebrates, yet the metabolic diversity and bioactive potential of noncommercialized, endemic species remains poorly understood.MethodsThis study presents the...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmars.2025.1609951

Low-grade chronic inflammation and transcriptomics: how molecular pharmacognosy can help find new natural treatment alternatives—a narrative review

Massimo Fioranelli, Maria Grazia Roccia, Bianca Przybylek, Francesca Romana Sconci et al. • Beni-Suef University Journal of Basic and Applied Sciences (2024)

Abstract Background The inflammatory response is fundamental to the maintenance of an organism’s physiological homeostasis. Inflammation is controlled by a series of biological events driven by specific inflammatory molecules. When inflamma...

DOAJ Open Access (DOAJ) DOI: 10.1186/s43088-024-00506-9

VirtualToxLab™ - In silico prediction of the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. Two years and 2,000 compounds of experience: a progress report

Angelo Vedani, Martin Smiesko, Morena Spreafico, Ourania Peristera et al. • ALTEX: Alternatives to Animal Experimentation (2009)

The VirtualToxLab™ is an in silico tool for predicting the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. It is based on a fully automated protocol and calculates the binding affinity of any molecule of int...

DOAJ Open Access (DOAJ) DOI: 10.14573/altex.2009.3.167

Mangifera Indica leaf extracts promote hair growth via activation of Wnt signaling pathway in human dermal papilla cells

Haesoo Jung, Da-Min Jung, Sang-Soo Lee, Eun-Mi Kim et al. • Animal Cells and Systems (2022)

The crosstalk between androgens and Wnt signaling pathways is critical in the hair growth cycle. Therefore, natural products that target these two pathways for the inhibition of hair loss are sought after. In this study, we investigated the...

DOAJ Open Access (DOAJ) DOI: 10.1080/19768354.2022.2085790

Developments in Exploring Fungal Secondary Metabolites as Antiviral Compounds and Advances in HIV-1 Inhibitor Screening Assays

Bruce Nzimande, John P. Makhwitine, Nompumelelo P. Mkhwanazi, Sizwe I. Ndlovu • Viruses (2023)

The emergence of drug-resistant Human Immunodeficiency Virus-1 strains against anti-HIV therapies in the clinical pipeline, and the persistence of HIV in cellular reservoirs remains a significant concern. Therefore, there is a continuous ne...

DOAJ Open Access (DOAJ) DOI: 10.3390/v15051039

A recent update on development, synthesis methods, properties and application of natural products derived carbon dots

Soumitra Sahana, Anupam Gautam, Rajveer Singh, Shivani Chandel • Natural Products and Bioprospecting (2023)

Abstract Natural resources are practically infinitely abundant in nature, which stimulates scientists to create new materials with inventive uses and minimal environmental impact. Due to the various benefits of natural carbon dots (NCDs) fr...

DOAJ Open Access (DOAJ) DOI: 10.1007/s13659-023-00415-x

Biological Potential of <i>Tsuga canadensis</i>: A Study on Seed, Cone Essential Oils, and Seed Lipophilic Extract

Anna Wajs-Bonikowska, Ewa Maciejczyk, Łukasz Szoka, Paweł Kwiatkowski et al. • Applied Sciences (2025)

This study investigates the essential oil (EO) isolated from the seeds and cones of Canadian hemlock (Tsuga canadensis), highlighting notable differences in their chemical composition and biological activities. The seed EO was uniquely domi...

DOAJ Open Access (DOAJ) DOI: 10.3390/app15041713

Molecular biology and integrated strategies for activating cryptic biosynthetic gene clusters toward next-generation antibiotic discovery

Veilumuthu Pattapulavar, Sathiyabama Ramanujam, Avanthi Yellampalli, Henu Sree Badiginchala et al. • Frontiers in Bioinformatics (2026)

Antimicrobial resistance (AMR) has been identified as one of the 21st century’s severest global public health crises. AMR led to an estimated 4.95 million deaths in 2019 and will claim 10 million lives a year by 2050 in the absence of targe...

DOAJ Open Access (DOAJ) DOI: 10.3389/fbinf.2026.1893206