Academic Articles & Research Papers

ROS/Enzyme Dual-Responsive Drug Delivery System for Targeted Colorectal Cancer Therapy: Synergistic Chemotherapy, Anti-Inflammatory, and Gut Microbiota Modulation

Objectives: Colorectal cancer (CRC) is a leading cause of cancer-related mortality, driven by chronic inflammation, gut microbiota dysbiosis, and complex tumor microenvironment interactions. Current therapies are limited by systemic toxicit...

Lemongrass (Cymbopogon Flexuosus Steud.) wats treated textile: A control measure against vector-borne diseases

Mosquito-borne diseases are one of the major threats to human health. The long-term use of synthetic repellents has made mosquitoes resistant to them leading to search for novel methods of mosquito control. In the present study, we have dev...

Risk Stratification of Elderly Patients Undergoing Spinal Surgery Using the Modified Frailty Index

Study Design: Retrospective cohort. Objectives: To validate the 11-item modified Frailty Index (mFI) as a perioperative risk stratification tool in elderly patients undergoing spine surgery. Methods: All consecutive cases of spine surgery i...

Colonic stenting as bridge to surgery versus emergency surgery for management of acute left-sided malignant colonic obstruction: a multicenter randomized trial (Stent-in 2 study)

Abstract Background Acute left-sided colonic obstruction is most often caused by malignancy and the surgical treatment is associated with a high mortality and morbidity rate. Moreover, these operated patients end up with a temporary or perm...

Mortality Certified as Diabetic Ketoacidosis Among Brazilian Children and Adolescents, 2015-2023: A National Time-Series Study of Trend and Cause-of-Death Coding Specificity.

Evaluation of recombinant activated protein C for severe sepsis at a tertiary academic medical center

Kevin E Anger,1 Jeremy R DeGrado,1 Bonnie C Greenwood,1 Steven A Cohen,2 Paul M Szumita1 1Department of Pharmacy, Brigham and Women’s Hospital, Boston, MA, USA; 2Department of Family Medicine and Population Health, Division of Epidemi...

Generation Scotland: Linking all the records we can

Objectives We started a family-based genetic epidemiology study in 2006-11 which recruited ~24,000 adult volunteers from ~7000 families across Scotland with consent for follow-up through medical record linkage and re-contact. In 2022-23 we ...

Women’s perception about the discovery of breast cancer amid the covid-19 pandemic

Background Breast cancer is considered a health problem at a worldwide level. In Brazil, the South and Southeast regions have the highest mortality rates. Understanding how they dealt with the diagnostic of a stigmatized disease amid the CO...

Impact of preprocedural frailty on long-term mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis.

Renin-angiotensin system inhibitors initiation and mortality in non-proteinuric chronic kidney disease: a target trial emulation.

Systematic Review and Meta-Analysis of the Transitions, Trajectories, and Associations With Mortality of Frailty in China.

Incidence, Prevalence, Mortality, and Disability-Adjusted Life Years Due to Cancer Among Adolescents Aged 10-19 Years in Iran, 1990-2023: A Trend Analysis of the Global Burden of Disease Study.

Development and Validation of a Mixture-of-Experts-Based Model for Postoperative In-Hospital Mortality Risk Assessment: Multicenter Retrospective Study.

Explainable machine learning for predicting in-hospital mortality in acute heart failure: a prospective single-center cohort study from Vietnam.

Emergency Department Boarding and Mortality: A Systematic Review and Proportional Meta-Analysis.

Associations of mortality and sepsis after GLP-1 receptor agonist initiation versus SGLT2 inhibitor or metformin initiation in people with HIV, overweight or obesity, and type 2 diabetes: A target trial emulation.

Rehabilitation professionals at the COVID-19 frontline: a testimony-informed narrative review of health-worker mortality, vaccine hesitancy, physiotherapy and telerehabilitation.

Early plasma cell-free DNA and monocyte human leukocyte antigen-DR expression for predicting 28-day mortality in sepsis: A single-center prospective cohort study with internal validation.

Inpatient mortality and predictors among adults hospitalized with severe malaria: a prospective cohort study in Southwest Ethiopia.

Cutaneous Aspergillosis Among Extremely Preterm Neonates in Neonatal Intensive Care Units - Michigan and New York, 2023-2024.