Tailoring industrial enzymes for thermostability and activity evolution by the machine learning-based iCASE strategy
Nan Zheng, Yongchao Cai, Zehua Zhang, Huimin Zhou et al. • Nature Communications
(2025)
Abstract The pursuit of obtaining enzymes with high activity and stability remains a grail in enzyme evolution due to the stability-activity trade-off. Here, we develop an isothermal compressibility-assisted dynamic squeezing index perturba...
DOAJ
Open Access (DOAJ)
DOI:
10.1038/s41467-025-55944-5