Academic Articles & Research Papers

Multiomics reveals alterations in the gut microbiome, host proteins, and host metabolites correlating with SADS-CoV pathogenicity and the immune response in piglets.

Intratumoral co-activation of ERV transcription and RNA virus-sensing is associated with radiotherapy-induced immune response and abscopal effect.

Divergent intestinal barrier and neuroimmune responses to supervised exercise across fibromyalgia, irritable bowel syndrome, and their comorbidity phenotypes: a prospective interventional study.

Microbiological mechanisms of immune response modulation: clinical implications.

The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis

Abstract The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer‐permissive functions. Moreover, brain metastases induce the recruitment of lymphocytes. Desp...

HumanViCe: Host ceRNA network in virus infected cells in human

Host-virus interaction via host cellular components has been an important field of research in recent times. RNA interference mediated by short interfering RNAs and microRNAs (miRNA), is a widespread anti-viral defence strategy. Importantly...

Concepts of Genetics

Part 1 Heredity and the phenotype: cell division - mitosis and meosis Mendalian genetics modification of Mendelian ratios linkage and chromosome mapping in eukaryotes recombination and mapping in bacteria and bacteriophages extensions of ge...

Remodeling of Metabolic and Secretory Organelles During Oncogenic and Oncomodulatory Viral Infections

Persistent oncovirus infections account for 15–20% of the global cancer burden, driving multiple forms of human cancer. To maintain persistent infection and spread, oncoviruses drive alterations in host cell metabolism, immune signaling, an...

Immunoinformatics and Reverse Vaccinology Approach for the Identification of Potential Vaccine Candidates against <i>Vandammella animalimors</i>

Vandammella animalimorsus is a Gram-negative and non-motile bacterium typically transmitted to humans through direct contact with the saliva of infected animals, primarily through biting, scratches, or licks on fractured skin. The absence o...

Comparative Immunogenicity and Safety of Measles-Mumps-Rubella Vaccine When Administered Using Needle Free Injection System to That with Conventional Needle-Syringe in India: A Randomized, Parallel Group Study

B S Ratta,1,&amp;ast; Ankur Naik,2,&amp;ast; Sarvesh Mutha3,&amp;ast; 1Consultant Paediatric Surgeon, Ruby Hall Clinic, Pune, India; 2Chief Technology Officer, IntegriMedical Private Limited, Pune, India; 3Chief Business Officer, IntegriMed...

In silico design of a triple-negative breast cancer vaccine by targeting cancer testis antigens

Introduction: Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CT...

Rhizospheric Microbes and Nanoparticles Synergize to Enhance Plant Immune Responses

ABSTRACT Sustainable crop production increasingly requires innovative strategies that can enhance plant resilience while reducing dependence on synthetic agrochemicals. Recent advances in nanotechnology and rhizosphere microbiome research h...

ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine

Despite numerous studies on cancer treatment, cancer remains a challenging disease to cure, even after decades of research. In recent years, the cancer vaccine has emerged as a promising approach for cancer treatment, offering few unexpecte...

Nanotechnology and its Applications in Medicine

Nanotechnologyis the study of extremely small structures, having size of 0.1 to 100 nm. Nano medicine is a relatively new field of science and technology. Brief explanation of various types of pharmaceutical nano systems is given. Classific...

The StABI5-<i>StCAT1</i> Module Regulates Potato Resistance to Early Blight Through the ROS Signaling Pathway

Potato early blight is a fungal disease caused by Alternaria solani that seriously affects potato production. Catalase (CAT), an important antioxidant enzyme in plants, regulates the basal immune response to necrotrophic pathogens by decomp...

Detection of selection signatures for response to Aleutian mink disease virus infection in American mink

Abstract Aleutian disease (AD) is the most significant health issue for farmed American mink. The objective of this study was to identify the genomic regions subjected to selection for response to infection with Aleutian mink disease virus ...

The Role of Iron in Phytopathogenic Microbe–Plant Interactions: Insights into Virulence and Host Immune Response

Iron is an essential element required for the growth and survival of nearly all forms of life. It serves as a catalytic component in multiple enzymatic reactions, such as photosynthesis, respiration, and DNA replication. However, the excess...

Nucleotide-binding oligomerization domain protein-1 is expressed and involved in the inflammatory response in human sebocytes

Sebocytes express Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), which participate in the innate immune response of the skin. Although the roles of TLRs and NLR family pyrin domain-cont...

Identification of functional pathways for regenerative bioactivity of selected renal cells

Abstract Background Selected renal cells (SRC) are in Phase II clinical trials as a kidney-sourced, autologous, tubular epithelial cell-enriched cell-based therapy for chronic kidney disease (CKD). In preclinical studies with rodent models ...

Identification of Dysregulated Mechanisms and Candidate Gene Markers in Chronic Obstructive Pulmonary Disease

Jie Lin,1,2,&ast; Yanlong Xue,1,2,&ast; Wenyan Su,1,2,&ast; Zan Zhang,1,2 Qiu Wei,1,2 Tianxia Huang1,2 1Department of Respiratory and Critical Care, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530022, Peop...