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CAFs activated by YAP1 upregulate cancer matrix stiffness to mediate hepatocellular carcinoma progression

Wei Yan, Guo-hui Xiao, Li-juan Wang, Yan Zhou et al. • Journal of Translational Medicine (2025)

Abstract Background The stiffness of the matrix is closely related to the progression of hepatocellular carcinoma (HCC). Although direct targeting of stromal rigidity in HCC remains a clinical challenge, cancer-associated fibroblasts (CAFs)...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12967-025-06325-5

Sequential Portal Vein Embolization and Percutaneous Radiofrequency Ablation for Future Liver Remnant Growth: A Minimally Invasive Alternative to ALPPS Stage-1 in Treatment of Hepatocellular Carcinoma

Qiang Wang, Qiang Wang, Yujun Ji, Torkel B. Brismar et al. • Frontiers in Surgery (2021)

Background: To evaluate the feasibility and efficacy of sequential portal vein embolization (PVE) and radiofrequency ablation (RFA) (PVE+RFA) as a minimally invasive variant for associating liver partition and portal vein ligation for stage...

DOAJ Open Access (DOAJ) DOI: 10.3389/fsurg.2021.741352

Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats

Fatma SM Moawed, Sawsan M El-Sonbaty, Somaya Z Mansour • Tumor Biology (2019)

Combining chemotherapy with radiotherapy potentiates the outcome of cancer treatment for the more comprehensive attack. In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanopartic...

DOAJ Open Access (DOAJ) DOI: 10.1177/1010428319834856

MBOAT7-TMC4 rs641738 Is Not Associated With the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection

Peng Wang, Ying Li, Lu Li, Rong Zhong et al. • Frontiers in Oncology (2021)

ObjectiveA hot genetic variant, rs641738 within the membrane-bound O-acyltransferase domain containing 7(MBOAT7) and transmembrane channel-like 4 (TMC4), was recently reported to be associated with several liver diseases. However, the resul...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2021.639438

Electronic symptom monitoring of patient-reported outcomes among patients with hepatocellular carcinoma during immunotherapy (PRIME-HCC): protocol for a randomised controlled trial

Yanshang Wang, Xiaoping Wei • BMJ Open (2026)

Introduction Electronic patient-reported outcome (ePROs)-based symptom monitoring benefits health-related quality of life (HRQoL) in various cancers. However, despite the high disease and economic burden of hepatocellular carcinoma (HCC) an...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2026-116199

Lymphoid Enhancer Factor 1 Contributes to Hepatocellular Carcinoma Progression Through Transcriptional Regulation of Epithelial‐Mesenchymal Transition Regulators and Stemness Genes

Chih‐Li Chen, Yu‐Shuen Tsai, Yen‐Hua Huang, Yuh‐Jin Liang et al. • Hepatology Communications (2018)

Lymphoid enhancer factor 1 (LEF1) activity is associated with progression of several types of cancers. The role of LEF1 in progression of hepatocellular carcinoma (HCC) remains poorly known. We investigated LEF1 expression in HCC and its in...

DOAJ Open Access (DOAJ) DOI: 10.1002/hep4.1229

CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling

Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu et al. • Cellular & Molecular Biology Letters (2025)

Abstract Background Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (H...

DOAJ Open Access (DOAJ) DOI: 10.1186/s11658-025-00690-1

Deep learning-based MRI model for predicting P53-mutated hepatocellular carcinoma

Lulu Jia, Qing Yang, Hanchen Jiang, Gang Huang et al. • BMC Medical Imaging (2025)

Abstract Background The P53-mutated Hepatocellular Carcinoma (HCC) is an aggressive variant associated with vascular endothelial growth factor (VEGF) overexpression and increased microvascular density. This study aimed to develop an MRI-bas...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12880-025-02045-w

AI enhanced diagnostic accuracy and workload reduction in hepatocellular carcinoma screening

Rui-Fang Lu, Chao-Yin She, Dan-Ni He, Mei-Qing Cheng et al. • npj Digital Medicine (2025)

Abstract Hepatocellular carcinoma (HCC) ultrasound screening encounters challenges related to accuracy and the workload of radiologists. This retrospective, multicenter study assessed four artificial intelligence (AI) enhanced strategies us...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41746-025-01892-9