Academic Articles & Research Papers

LncRNA-Top: Controlled deep learning approaches for lncRNA gene regulatory relationship annotations across different platforms

Summary: By soaking microRNAs (miRNAs), long non-coding RNAs (lncRNAs) have the potential to regulate gene expression. Few methods have been created based on this mechanism to anticipate the lncRNA-gene relationship prediction. Hence, we pr...

Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics

Recent studies in cancer diagnostics have identified microRNAs (miRNAs) as promising cancer biomarkers. Single nucleotide polymorphisms (SNPs) in miRNA binding sites, seed regions, and coding sequences can help predict breast cancer risk, a...

Genetics : a conceptual approach

Introduction to Genetics Genetics Is Important to Us Individually, to Society, and to the Study of Biology Humans Have Been Using Genetics for Thousands of Years A Few Fundamental Concepts Are Important for the Start of Our Journey into Gen...

Identifying elemental genomic track types and representing them uniformly

Abstract Background With the recent advances and availability of various high-throughput sequencing technologies, data on many molecular aspects, such as gene regulation, chromatin dynamics, and the three-dimensional organization of DNA, ar...

Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes

Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth

Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ. Its primary mechanism o...

Molecular Biology of the Gene

The long-awaited Fifth Edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA doub...

The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2 [v1; ref status: indexed, http://f1000r.es/201]

The primary function of the dsRNA binding protein (dsRBP) PACT/RAX is to activate the dsRNA dependent protein kinase PKR in response to stress signals.  Additionally, it has been identified as a component of the small RNA processing pathway...

The Advances of Single-Cell RNA-Seq in Kidney Immunology

Kidney diseases are highly prevalent and treatment is costly. Immune cells play important roles in kidney diseases; however, it has been challenging to investigate the contribution of each cell type in kidney pathophysiology. Recently, the ...

Understanding the regulatory grammar of sepsis-causing Staphylococcus aureus bacteria using contexualised DNA language models

Abstract To efficiently and accurately understand, detect, and treat sepsis, we require a deep understanding of how its underlying biological systems work. Conventional methods struggle to provide a detailed view of both the functional and ...

Predicting cell-state-specific gene regulation from DNA across species.

Using Network-Based Machine Learning to Predict Transcription Factors Involved in Drought Resistance

Gene regulatory networks underpin stress response pathways in plants. However, parsing these networks to prioritize key genes underlying a particular trait is challenging. Here, we have built the Gene Regulation and Association Network (GRA...

Editorial: Modern machine learning approaches for quantitative inference of gene regulation from genomic and epigenomic features