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Showing 13 of 13 academic articles

FAM83A as a Potential Biological Marker Is Regulated by miR-206 to Promote Cervical Cancer Progression Through PI3K/AKT/mTOR Pathway

Li Rong, Haiyu Li, Zhaodong Li, Jing Ouyang et al. • Frontiers in Medicine (2020)

Background and Objective: Chemotherapy and radiotherapy are effective treatment options for cervical cancer (CC), but their efficacy is limited by short survival rate of about 5 years particularly for advance stage CC. Bioinformatics analys...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2020.608441

Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway

Qian Qin, Zhiyan Shan, Lei Xing, Yutong Jiang et al. • Journal of Translational Medicine (2024)

Abstract Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder predominant in childhood. Despite existing treatments, the benefits are still limited. This study explored the effectiveness of mesenchymal stem cell-deri...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12967-024-05257-w

An integrated analysis of multiple datasets reveals novel gene signatures in human granulosa cells

Xhulio Dhori, Silvia Gioiosa, Stefania Gonfloni • Scientific Data (2024)

Abstract Granulosa cells (GCs) play crucial roles in oocyte maturation. Through gap junctions and extracellular vesicles, they mediate the exchange of molecules such as microRNAs and messenger RNAs. Different ovarian cell types exhibit uniq...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41597-024-03715-0

Dysregulation of Angiogenesis and Inflammatory Genes in Endometrial Mesenchymal Stem Cells and Their Contribution to Endometriosis

Shermineh Heydari, Ladan Kashani, Mehrdad Noruzinia • Iranian Journal of Allergy, Asthma and Immunology (2021)

Endometriosis is a common, chronic, inflammatory disorder in women, characterized by the presence of endometrial tissue outside the uterus cavity. The disease affects ~10% of women during their reproductive age. There is some debates on the...

DOAJ Open Access (DOAJ)

miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4

Jinyu Liu, Xiaowei Yuan, Wei Chen, Dongqin Shen • Clinical and Applied Thrombosis/Hemostasis (2026)

Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis dia...

DOAJ Open Access (DOAJ) DOI: 10.1177/10760296261468449

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Brianna Dufek, Daniel T Meehan, Duane Delimont, Kevin Wilhelm et al. • PLoS ONE (2020)

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels o...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0237907

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase

Jing Yang, Pengfei Li, Pengfei Li, Pengfei Li et al. • Frontiers in Immunology (2022)

ObjectiveExtranodal natural killer/T cell lymphoma (NKTCL) is an aggressive EBV-related lymphoma, originating from NK cells or T cells. Previous study demonstrated that CD56 negative NKTCL should be recognized as a distinct subtype. In this...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2022.829366

Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Wentong Chen, Mengxiao Ge, Shuangyi Sun, Hanxiao Zhang et al. • Scientific Reports (2025)

Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-32406-y

CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia

Weiwei Liu, Yan Wang, Zhimei Qiu, Ranzun Zhao et al. • PeerJ (2020)

Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia. Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are involved in the regulation of physiological and pathophy...

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.9796

Draft genome sequences of two hypermucoviscous carbapenem-resistant ST25 Klebsiella pneumoniae strains causing respiratory and systemic infections

María Angela Jure, Leonardo Albarracin, Juan Martin Vargas, Stefania Dentice Maidana et al. • Journal of Global Antimicrobial Resistance (2021)

ABSTRACT: Objectives: The emergence and spread of hypermucoviscous KPC-2-producing Klebsiella pneumoniae strains belonging to the sequence type 25 (ST25) clone was reported recently in Northwest Argentina as a leading cause of nosocomial in...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jgar.2021.05.018

Integrated Bioinformatics Analysis and Experimental Verification of Immune Cell Infiltration and the Related Core Genes in Ulcerative Colitis

Zhao D, Qin D, Yin L, Yang Q • Pharmacogenomics and Personalized Medicine (2023)

Danya Zhao,1 Danping Qin,2 Liming Yin,3 Qiang Yang4 1The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of Gastroenterology, The First Affiliated Hospital of Zheji...

DOAJ Open Access (DOAJ)

Identification of arachidonic acid metabolism-related diagnostic markers in heart failure based on bioinformatics analysis and machine learning

Saiqing Chen, Chunxia Zhang, Yueting Yu • Frontiers in Cardiovascular Medicine (2025)

BackgroundHeart failure (HF) represents the terminal phase of multiple cardiovascular conditions and is associated with significant morbidity and mortality rates. Arachidonic acid (AA), an essential fatty acid, plays a crucial role in modul...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcvm.2025.1625064