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Postbiotics in Functional Foods: Preparation-Based Characterization, Gut–Brain Axis Interactions, and Translational Perspectives

Selin Elmas, Daniela Cîrțînă, Rodica Dîrnu, Ion Dorin Plută et al. • Foods (2026)

Postbiotics are defined as preparations of inanimate microorganisms and/or their components that confer a health benefit on the host. Although interest in postbiotics has increased substantially, their translational use in functional foods ...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods15142457

Nanosized Cubosomal Thermogelling Dispersion Loaded with Saquinavir Mesylate to Improve Its Bioavailability: Preparation, Optimization, in vitro and in vivo Evaluation

Hosny KM • International Journal of Nanomedicine (2020)

Khaled M Hosny1,2 1Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptCorrespon...

DOAJ Open Access (DOAJ)

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review

Seyedeh Alia Moosavian, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar • Bioinorganic Chemistry and Applications (2021)

Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to end-stage liver disease needing a liver transplant. Many pharmacological approaches are used to reduce the disease progression in NAFLD. However, cu...

DOAJ Open Access (DOAJ) DOI: 10.1155/2021/4041415

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Yujing Huang, Xiaohan Guo, Yi Wu, Xingyu Chen et al. • Signal Transduction and Targeted Therapy (2024)

Abstract Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergenc...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41392-024-01745-z

Nanotechnology-Based Cosmeceuticals

Alka Lohani, Anurag Kumar Verma, Himanshi Joshi, Niti Yadav et al. • ISRN Dermatology (2014)

Cosmeceuticals are the fastest growing segment of the personal care industry, and a number of topical cosmeceutical treatments for conditions such as photoaging, hyperpigmentation, wrinkles, and hair damage have come into widespread use. In...

OPENALEX cc-by DOI: https://doi.org/10.1155/2014/843687 PMC: 4055113

Polyphenols: From Theory to Practice

Alberto Bertelli, Marco Biagi, Maddalena Corsini, Giulia Baini et al. • Foods (2021)

Background: The importance of polyphenols in human health is well known; these compounds are common in foods, such as fruits, vegetables, spices, extra virgin olive oil and wine. On the other hand, the different factors that modulate the bi...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods10112595

Application of a novel pH-responsive gemini surfactant for delivery of curcumin molecules

Maral Rahimzadeh, Majid Sadeghizadeh, Farhood Najafi, Seyed Shahriar Arab et al. • Materials Research Express (2020)

During the last few decades, extensive studies have been conducted to elucidate the anti-cancer effects of curcumin. Despite promising results indicating curcumin could impede cancer cells ability thrive and proliferation, clinical applicat...

DOAJ Open Access (DOAJ) DOI: 10.1088/2053-1591/ab770f

Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative

Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares et al. • Molecules (2021)

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural mod...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules26226923

The Utilization of Plant-Material-Loaded Vesicular Drug Delivery Systems in the Management of Pulmonary Diseases

Bongani Sannyboy Lukhele, Kokoette Bassey, Bwalya Angel Witika • Current Issues in Molecular Biology (2023)

Medicinal plants have been utilized to treat a variety of conditions on account of the bioactive properties that they contain. Most bioactive constituents from plants are of limited effectiveness, due to poor solubility, limited permeabilit...

DOAJ Open Access (DOAJ) DOI: 10.3390/cimb45120624

Enteric Coating Enhances the Biopharmaceutical Performance of a Silica–Lipid Formulation of Abiraterone Acetate

Ali Taheri, Ruba Almasri, Anthony Wignall, Felicia Feltrin et al. • Pharmaceutics (2025)

Background/Objectives: Lipid-based formulations are widely used to enhance the oral bioavailability of poorly water-soluble drugs. However, for weakly basic drugs with higher solubility under acidic conditions, precipitation and recrystalli...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics17101289

Relationship between Pb relative bioavailability and bioaccessibility in phosphate amended soil: Uncertainty associated with predicting Pb immobilization efficacy using in vitro assays

Farzana Kastury, Silvia Placitu, John Boland, Ranju R. Karna et al. • Environment International (2019)

In this study, an in vitro in vivo correlation (IVIVC) between Pb in vitro bioaccessibility (IVBA) and relative bioavailability (RBA) was explored to determine whether the efficacy of Pb immobilization in phosphate amended soils could be pr...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.envint.2019.104967

Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges

Kirsten M. Wright, Janis McFerrin, Armando Alcázar Magaña, Armando Alcázar Magaña et al. • Frontiers in Nutrition (2022)

Botanical products are frequently sold as dietary supplements and their use by the public is increasing in popularity. However, scientific evaluation of their medicinal benefits presents unique challenges due to their chemical complexity, i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2021.799137

Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions

Kevin O. Murray, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Douglas R. Seals et al. • Experimental Gerontology (2023)

Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffeni...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2023.112105

Vesicular Carriers for Phytochemical Delivery: A Comprehensive Review of Techniques and Applications

Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Rekha Rao et al. • Pharmaceutics (2025)

Natural substances, especially those derived from plants, exhibit a diverse range of therapeutic benefits, such as antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Nevertheless, their use in clinical settings is freque...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics17040464

A Single Simulated Heliox Dive Modifies Endothelial Function in the Vascular Wall of ApoE Knockout Male Rats More Than Females

Simin Berenji Ardestani, Simin Berenji Ardestani, Vladimir V. Matchkov, Ingrid Eftedal et al. • Frontiers in Physiology (2019)

IntroductionThe number of divers is rising every year, including an increasing number of aging persons with impaired endothelial function and concomitant atherosclerosis. While diving is an independent modulator of endothelial function, lit...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphys.2019.01342

Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives

Yao Li, Qiu Chen, Tingting Wang, Zengkai Ji et al. • Journal of Nanobiotechnology (2025)

Abstract As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative dru...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03432-9

Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease

Hamid Reza Rahimi, Mahmoud Reza Jaafari, Amir Hooshang Mohammadpour, Khalil Abnous et al. • Asia Pacific Journal of Medical Toxicology (2015)

Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal me...

DOAJ Open Access (DOAJ) DOI: 10.22038/apjmt.2015.3983

Flexibility-powered Pickering emulsion enhances mucus permeability to alleviate ulcerative colitis

Jiali Lv, Chen Cheng, Xinran Liu, Jinhua Song et al. • Journal of Nanobiotechnology (2025)

Abstract The physicochemical properties of oral drug delivery carriers significantly influence their interactions with the intestinal barrier, which, in turn, affect their in vivo fate and therapeutic efficacy. As a delivery system with a h...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03829-6