Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation
Akihiro Sugai, Taisuke Kato, Akihide Koyama, Yuka Koike et al. • Neurobiology of Disease
(2019)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by accumulation of fragmented insoluble TDP-43 and loss of TDP-43 from the nucleus. Increased expression of exogenous TARDBP (encoding TDP-43) induces TDP-43 p...
DOAJ
Open Access (DOAJ)
DOI:
10.1016/j.nbd.2019.104534