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Academic Articles & Research Papers
Showing 20 of 41 academic articles
Kepu Zheng, Leiyang Dai, Yanghui Wen, Haitao Jiang et al. • Annals of Medicine
(2026)
Background Macrophages are central regulators of liver immunity and fibrosis; Recent single-cell studies have characterized macrophage heterogeneity in cirrhosis; however, how regulated cell death programs shape their functional transitions...
DOAJ
Open Access (DOAJ)
DOI: 10.1080/07853890.2026.2690717
Liu Y, Song X, Wu M, Wu J et al. • Cancer Management and Research
(2020)
Yusi Liu, Xue Song, Moli Wu, Jiao Wu, Jia Liu Liaoning Laboratory of Cancer Genetics and Epigenetics and Department of Cell Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, People’s Republic of ChinaCorre...
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Open Access (DOAJ)
S.K. Verma, A. Thirumurugan, P.K. Panda, P. Patel et al. • Materials Today Bio
(2021)
Recent advancement in nanotechnology seeks exploration of new techniques for improvement in the molecular, chemical, and biological properties of nanoparticles. In this study, carbon modification of octahedral-shaped magnetic nanoparticles ...
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Open Access (DOAJ)
DOI: 10.1016/j.mtbio.2021.100131
Tommaso A. Salamone, Sofia Marotta, Stella Mrmić, Salvatore Raffa et al. • Cancer Nanotechnology
(2025)
Abstract Background Trastuzumab (TZ) resistance remains a significant challenge in the treatment of human epidermal growth factor receptor 2 (HER2)-positive epithelial ovarian cancer (EOC), necessitating novel therapeutic strategies to impr...
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Open Access (DOAJ)
DOI: 10.1186/s12645-025-00330-5
Maria B. C. de Matos, Roel Deckers, Benjamin van Elburg, Guillaume Lajoinie et al. • Frontiers in Pharmacology
(2019)
Mistletoe lectin-1 (ML1) is a nature-derived macromolecular cytotoxin that potently induces apoptosis in target cells. Non-specific cytotoxicity to normal cells is one of the major risks in its clinical application, and we therefore propose...
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Open Access (DOAJ)
DOI: 10.3389/fphar.2019.01463
Mahadevaswamy G. Kuruburu, Venugopal R. Bovilla, Rimshia Naaz, Zonunsiami Leihang et al. • Frontiers in Pharmacology
(2026)
Epidemiological studies have demonstrated an inverse correlation between millet-based diets and incidence of cancers of colon and rectum. These findings highlight the potential of millets as functional foods for effective management of canc...
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Open Access (DOAJ)
DOI: 10.3389/fphar.2026.1805287
Maral Rahimzadeh, Majid Sadeghizadeh, Farhood Najafi, Seyed Shahriar Arab et al. • Materials Research Express
(2020)
During the last few decades, extensive studies have been conducted to elucidate the anti-cancer effects of curcumin. Despite promising results indicating curcumin could impede cancer cells ability thrive and proliferation, clinical applicat...
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Open Access (DOAJ)
DOI: 10.1088/2053-1591/ab770f
Wentong Chen, Mengxiao Ge, Shuangyi Sun, Hanxiao Zhang et al. • Scientific Reports
(2025)
Abstract As critical precursors to colorectal cancer (CRC), high-risk colorectal adenomas (HR-CRAs) lack effective chemopreventive strategies beyond endoscopic resection. We previously established a standardized protocol for culturing patie...
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Open Access (DOAJ)
DOI: 10.1038/s41598-025-32406-y
Man Luo, Man Luo, Man Luo, Jiang Zhu et al. • Frontiers in Pharmacology
(2025)
BackgroundDrug repurposing has emerged as a promising approach for discovering novel anticancer therapeutics. In this study, we systematically investigated the antitumor potential of fedratinib, a JAK2 inhibitor approved for myelofibrosis, ...
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Open Access (DOAJ)
DOI: 10.3389/fphar.2025.1689663
Xuanzhao Chen, Zeyan Li, Meihua Liang, Ziyang Zhang et al. • World Journal of Surgical Oncology
(2023)
Abstract Background Triple-negative breast cancer (TNBC) is the most heterogenous and aggressive subtype of breast cancer. Chemotherapy remains the standard treatment option for patients with TNBC owing to the unavailability of acceptable t...
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Open Access (DOAJ)
DOI: 10.1186/s12957-023-03078-7
Gomaa Mostafa-Hedeab, Amany Behairy, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed et al. • Antioxidants
(2023)
This study assessed the possible protective role of green synthesized zinc oxide nanoparticles using Moringa olifera leaf extract (MO-ZNPs) in acrylamide (ACR)-induced reproductive dysfunctions in male rats. ACR (20 mg/kg b.wt/day) and/or M...
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Open Access (DOAJ)
DOI: 10.3390/antiox12020361
Su Been Park, Gun Hee Cho, Young Eun Park, Hyang Sook Chun • Toxins
(2023)
Emodin, an emerging mycotoxin, is known to be hepatotoxic, but its mechanism remains unclear. We hypothesized that emodin could induce endoplasmic reticulum (ER) stress through the inositol-requiring enzyme 1 alpha (IRE1α)–X-box-binding pro...
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Open Access (DOAJ)
DOI: 10.3390/toxins15070455
Sarah Damanti, Sarah Damanti, Lorena Citterio, Laura Zagato et al. • Frontiers in Endocrinology
(2024)
BackgroundObesity and frailty are prevalent geriatric conditions that share some pathophysiological mechanisms and are associated with adverse clinical outcomes. The relationship between frailty, obesity, and polymorphism remains inadequate...
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Open Access (DOAJ)
DOI: 10.3389/fendo.2024.1412160
Huifang Lian, Huifang Lian, Huifang Lian, Huifang Lian et al. • Frontiers in Medicine
(2022)
PurposeFungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain ...
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Open Access (DOAJ)
DOI: 10.3389/fmed.2022.845129
Michelle S. Liberio, Martin C. Sadowski, Colleen C. Nelson, Rohan A. Davis • Marine Drugs
(2014)
Ascidians are marine invertebrates that have been a source of numerous cytotoxic compounds. Of the first six marine-derived drugs that made anticancer clinical trials, three originated from ascidian specimens. In order to identify new anti-...
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Open Access (DOAJ)
DOI: 10.3390/md12105222
Lufei Chen, Chaoxian Dai, Zhenfang Wu, Yuhan Lin et al. • Journal of Xenobiotics
(2026)
Accumulating epidemiological evidence links ambient PM2.5 exposure to elevated Parkinson’s disease (PD) risk, yet the neurotoxicity triggered by PM2.5 multi-pollutant mixtures under real co-exposure scenarios remains insufficiently elucidat...
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Open Access (DOAJ)
DOI: 10.3390/jox16060184
Sarah Al-Nasser, Maha Hamadien Abdulla, Noura Alhassan, Mansoor-Ali Vaali-Mohammed et al. • Medicina
(2024)
Background and Objectives: Colorectal cancer (CRC) remains a major global health issue. Although chemotherapy is the first-line treatment, its effectiveness is limited due to drug resistance developed in CRC. To overcome resistance and impr...
DOAJ
Open Access (DOAJ)
DOI: 10.3390/medicina60091379
Hao Zhang, Hao Zhang, Hao Zhang, Penghui Ye et al. • Frontiers in Immunology
(2026)
BackgroundHigh-altitude hypoxia disrupts intestinal homeostasis by impairing the epithelial barrier, triggering inflammation, and promoting microbial translocation. Berberine (BER), a natural isoquinoline alkaloid with antimicrobial and ant...
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Open Access (DOAJ)
DOI: 10.3389/fimmu.2026.1784245
Sahar Esfandyari, Ashraf Aleyasin, Zahra Noroozi, Maryam Taheri et al. • Cell Journal
(2021)
Objective: Sulforaphane (SFN) is a natural free radical scavenger that can reduce oxidative stress (OS) through mediating nuclear factor (erythroid-derived 2)-like 2 (NF-E2-related factor 2 or NRF2)/antioxidant response element (ARE) signal...
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Open Access (DOAJ)
DOI: 10.22074/cellj.2021.7393
Cagri Yalgin, Bohdana Rovenko, Ana Andjelković, Margot Neefjes et al. • iScience
(2020)
Summary: Dopaminergic (DA) neurons have been implicated as key targets in neurological disorders, notably those involving locomotor impairment, and are considered to be highly vulnerable to mitochondrial dysfunction, a common feature of suc...
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Open Access (DOAJ)
DOI: 10.1016/j.isci.2020.101362