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Evaluating the Effects of Molecular Dynamic And Docking of Abemaciclib, Hymenialdisine, and Indirubin on CDK-2 Inhibition by Simulation Study

Majid Asadi-Samani, Navid Jamali, Javad Saffari-Chaleshtori, Korosh Ashrafi-Dehkordi • Journal of Ardabil University of Medical Sciences (2022)

Background & objectives: Cyclin-dependent kinase 2 (CDK-2) is a serine/threonine protein kinase with regulatory activity in the cell cycle. Inhibitors of this protein are the treatment of choice for a variety of cancers by stopping the cell...

DOAJ Open Access (DOAJ)

Amino Acid Racemase Enzyme Assays

Atanas Radkov, Luke Moe • Bio-Protocol (2014)

Amino acid racemases are enzymes that invert the α-carbon stereochemistry of amino acids (AAs), interconverting amino acids between their L- and D-enantiomers in a reversible reaction. In bacteria, they are known to have catabolic physiolog...

DOAJ Open Access (DOAJ) DOI: 10.21769/BioProtoc.1112

Assessment of Safety and Probiotic Traits of Enterococcus durans OSY-EGY, Isolated From Egyptian Artisanal Cheese, Using Comparative Genomics and Phenotypic Analyses

Walaa E. Hussein, Walaa E. Hussein, Ahmed G. Abdelhamid, Ahmed G. Abdelhamid et al. • Frontiers in Microbiology (2020)

An Enterococcus durans strain, designated OSY-EGY, was previously isolated from artisanal cheese. In this work, comparative genomic and phenotypic analyses were utilized to assess the safety characteristics and probiotic traits of the bacte...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2020.608314

Sex-based estimation of biological variation in plasma-free amino acid concentrations among healthy adults

Müjgan Ercan, Emiş Deniz Akbulut, Ayşen Caniklioğlu, Esra Fırat Oğuz et al. • Journal of Mass Spectrometry and Advances in the Clinical Lab (2025)

Introduction: Free amino acid (FAA) analysis plays a crucial role in diagnosing and monitoring inborn errors of metabolism, assessing nutritional status, and identifying metabolic imbalances associated with various diseases. This study aime...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmsacl.2025.04.010

Untargeted metabolomic profiling of Pseudocnella sykion from KwaZulu-Natal, South Africa using 1H-NMR and UPLC-QTOF-HR-MS

Cassandra Upton, Gerhard Prinsloo, Paul Anton Steenkamp, Moses Okpeku • Frontiers in Marine Science (2025)

IntroductionSea cucumbers are ecologically and economically significant marine invertebrates, yet the metabolic diversity and bioactive potential of noncommercialized, endemic species remains poorly understood.MethodsThis study presents the...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmars.2025.1609951

Study on the correlation of supplementation with L-citrulline on the gastrointestinal flora and semen antifreeze performance of ram

Chen Fan, Chen Fan, Aikebaier Aihemaiti, Aikebaier Aihemaiti et al. • Frontiers in Microbiology (2024)

IntroductionCryopreservation of semen can give full play to the reproductive advantages of male animals. However, in actual production, due to the poor frost resistance of sheep semen and the low conception rate, the promotion of sheep froz...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2024.1396796

Enhancing Rosemary (<i>Rosmarinus officinalis</i>, L.) Growth and Volatile Oil Constituents Grown under Soil Salinity Stress by Some Amino Acids

Ahmad H. Al-Fraihat, Sati Y. Al-Dalain, Ahmad A. Zatimeh, Moawiya A. Haddad • Horticulturae (2023)

The current study was carried out during the two consecutive winter seasons of 2019/2020 and 2020/2021 at the Experimental Farm of Ash-Shoubak University College, Jordan, as a pot experiment. This experiment was planned to evaluate the impa...

DOAJ Open Access (DOAJ) DOI: 10.3390/horticulturae9020252

Effects of different thermal processing methods on the flavor and precursor substances of the longissimus dorsi muscle in the “Duroc × Landrace × Yorkshire” ternary hybrid pigs

Xinran Yuan, Jialing Tang, Yulin Zhang, Zhengfeng Fang et al. • Food Chemistry: X (2026)

This study investigated the effects of boiling, frying, and roasting on flavor compounds and their precursors in the longissimus dorsi muscle of “Duroc × Landrace × Yorkshire” pigs. HS-SPME-GC–MS, electronic nose analysis, and multivariate ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.fochx.2026.103935

Unveiling the Assembly of Neutral Marine Polysaccharides into Electrostatic-Driven Layer-by-Layer Bioassemblies by Chemical Functionalization

Luís P. G. Monteiro, João Borges, João M. M. Rodrigues, João F. Mano • Marine Drugs (2023)

Marine-origin polysaccharides, in particular cationic and anionic ones, have been widely explored as building blocks in fully natural or hybrid electrostatic-driven Layer-by-Layer (LbL) assemblies for bioapplications. However, the low chemi...

DOAJ Open Access (DOAJ) DOI: 10.3390/md21020092

A Novel Anticancer Peptide Derived from <i>Bryopsis plumosa</i> Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells

Heabin Kim, Hyun-Taek Kim, Seung-Hyun Jung, Jong Won Han et al. • Marine Drugs (2023)

The discovery of new highly effective anticancer drugs with few side effects is a challenge for drug development research. Natural or synthetic anticancer peptides (ACPs) represent a new generation of anticancer agents with high selectivity...

DOAJ Open Access (DOAJ) DOI: 10.3390/md21120607

Varieties of Mushrooms and their Nutraceutical Importance: A Systematic Review

Debasmita Chatterje, Dipankar Halder, Satadal Das • Journal of Clinical and Diagnostic Research (2021)

Introduction: Around 2000 species of mushrooms exist in nature, of which hardly 25 varieties are accepted as edible in nature. “Nutraceuticals” are food substances that are associated with immense health benefits and also hinder the deve...

DOAJ Open Access (DOAJ) DOI: 10.7860/JCDR/2021/47240.14660

Chemical Diversity of Fuzhuan Brick Teas from Hunan and Shaanxi

ZHANG Ning, YU Shilan, YAN Haoyi, ZHANG Yunjun, HAN Xiaoyu, REN Hongyu, CHEN Yuqing, LING Tiejun, AN Maoqiang • Shipin Kexue (2024)

This study aimed to explore the diversity of metabolites and compare the metabolite profiles of Fuzhuan brick teas from Hunan and Shaanxi, to find out the difference in chemical components between fresh tea leaves and Fuzhuan brick tea and ...

DOAJ Open Access (DOAJ) DOI: 10.7506/spkx1002-6630-20231108-066

Effects of Hot Air-drying and Vacuum Freeze-drying on Flavor Components in Different Parts of Hericium erinaceus

Yihang ZHANG, Donglu FANG, Lei ZHONG, Qiuhui HU et al. • Shipin gongye ke-ji (2022)

In order to explore the changes of flavor characteristics of Hericium erinaceus before and after drying, the effects of hot air-drying and vacuum freeze-drying on flavor components of pileus and stipe of H. erinaceus were studied using high...

DOAJ Open Access (DOAJ) DOI: 10.13386/j.issn1002-0306.2021070247

Ethanolic extract of black soldier fly (Hermetia illucens L.) larvae for wound healing in mice (Mus musculus L.)

Darman Agung Sandakila, Gracetia Devita Hadi, Riska Gultom, Seni Samalele et al. • Aceh Journal of Animal Science (2024)

The Black Soldier Fly (Hermetia illucens L.) or BSF is one of a group of insects that has a length of 15-20 mm originating from America. The larvae of the BSF has a high protein content (44.26%), which has great potential in treating wound ...

DOAJ Open Access (DOAJ) DOI: 10.13170/ajas.9.3.42024

Exploring the formation mechanism of off-flavor of irradiated yak meat based on metabolomics

Qia Wang, Kai Dong, Yongyan Wu, Fengping An et al. • Food Chemistry: X (2022)

Irradiation's effects on quality, volatile compounds, and differential metabolites of yak meat were studied. Irradiation dose at 3 kGy had no effect on yak meat quality, however irradiation dose at 5 kGy resulted in yak meat quality deterio...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.fochx.2022.100494

Green Microfluidic Method for Sustainable and High-Speed Analysis of Basic Amino Acids in Nutritional Supplements

Iva Pukleš, Csilla Páger, Nikola Sakač, Bojan Šarkanj et al. • Molecules (2024)

Amino acids (AAs) have broad nutritional, therapeutic, and medical significance and thus are one of the most common active ingredients of nutritional supplements. Analytical strategies for determining AAs are high-priced and often limited t...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules29235554

PRODUCTION OF L-TRYPTOPHAN BY MUTANTS OF CORYNEBACTERIUM GLUTAMICUM

Hamies Mohamed, Ghada El Nady, A. Ali, A. Abdel-Razik et al. • Arab Universities Journal of Agricultural Sciences (2018)

L-Tryptophan, is one of the amino acids, also is one of the 9 essential amino acids of human which cannot be synthesized internally by him, microbial production is the main method for obtaining tryptophan for commercial uses. Typical microo...

DOAJ Open Access (DOAJ) DOI: 10.21608/ajs.2018.28383

Computer quantum chemical simulation of the interaction of magnesium phosphate with essential amino acids

A. A. Blinova, M. A. Pirogov, I. M. Shevchenko, P. S. Leontev et al. • Современная наука и инновации (2024)

As part of this work, a computer quantum chemical simulation of the interaction of magnesium phosphate with essential amino acids was carried out in order to determine the optimal stabilizer for Mg3(PO4)2 nanoparticles. Quantum chemical mod...

DOAJ Open Access (DOAJ) DOI: 10.37493/2307-910X.2023.4.7

P2′ Site Scanning of Snake Kunitz-Type Toxin Analogue BF9-N17H with Unique P1 Site Histidine Highlights Novel XIa Inhibitory Peptides Without Plasmin Inhibitory Activity

Luyao Wang, Li Ding, Tianxiang Qin, Xinyu Liu et al. • Toxins (2026)

Kunitz-type peptides from venomous and blood-sucking animals represent an important natural molecular resource for anticoagulant development towards XIa, a new target for antithrombotic drug discovery. However, the plasmin-inhibitory activi...

DOAJ Open Access (DOAJ) DOI: 10.3390/toxins18100449