MainReads

Discover Books. Explore Knowledge.

Home » Academic Articles & Research Papers

Academic Articles & Research Papers

Search and discover peer-reviewed scholarly literature, open-access articles, and research citations across DOAJ, PubMed Central, and OpenAlex.

Reset
Showing 4 of 4 academic articles

HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

Guy Karlebach, Peter Hansen, Diogo FT Veiga, Robin Steinhaus et al. • Genome Biology (2020)

Abstract We present Hierarchical Bayesian Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts. HBA-DEALS attains state of the art or be...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13059-020-02072-6

Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation

Akihiro Sugai, Taisuke Kato, Akihide Koyama, Yuka Koike et al. • Neurobiology of Disease (2019)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by accumulation of fragmented insoluble TDP-43 and loss of TDP-43 from the nucleus. Increased expression of exogenous TARDBP (encoding TDP-43) induces TDP-43 p...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nbd.2019.104534