Academic Articles & Research Papers

Functional and Effective Connectivity Characteristics of the Dorsolateral Prefrontal Cortex in Drug-Naïve Patients with Generalized Anxiety Disorder.

Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats

Autism spectrum disorder (ASD) is a developmental condition whose primary features include social communication and interaction impairments with restricted or repetitive motor movements. No approved treatment for the core symptoms is availa...

The Effectiveness of Simultaneous Training of Various Executive Functions (Hot and Cool; Focused on Simultaneous Parent-Child Training) on Improving the Empathy of Children with Attention Deficit Hyperactivity Disorder (ADHD)

The present study aimed to effectiveness of simultaneous training of various executive functions (hot and cool; focused on simultaneous parent-child training) on improving the empathy of children with attention deficit hyperactivity disorde...

Thematic structure of clinically oriented prefrontal function assessment and intervention research: a keyword network analysis

Abstract Background The prefrontal cortex (PFC) has been extensively investigated in relation to higher-order cognition, emotional regulation, and behavioural control, particularly within clinically oriented studies addressing psychiatric s...

Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice

Alzheimer’s disease is a progressive neurodegenerative disorder affecting around 30 million patients worldwide. The predominant sporadic variant remains enigmatic as the underlying cause has still not been identified. Since efficient therap...

Depressive phenotype shapes behavioral, neuroendocrine and molecular responses to repetitive transcranial magnetic stimulation in preclinical models of depression

IntroductionRepetitive transcranial magnetic stimulation (rTMS) is an established non-invasive treatment for treatment-resistant depression (TRD), yet its neurobiological mechanisms remain only partially understood. We investigated whether ...

Effects of individualized rTMS on functional connectivity related to the default mode network and frontal-parietal network in major depressive disorder: exploratory analysis of a randomized controlled trial

Objective: Repetitive transcranial magnetic stimulation (rTMS) has been shown to alleviate depressive and anxiety symptoms in patients with major depressive disorder (MDD), typically by targeting the dorsolateral (DLPFC) or dorsomedial pref...

Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders

Background: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fr...

Prefrontal cortical deficits are a putative susceptibility factor for PTSD

IntroductionOnly a subset of people who experience a traumatic event develop Post-Traumatic Stress Disorder (PTSD) suggesting that there are susceptibility factors influencing PTSD pathophysiology. While post trauma sequelae factors are ext...

Real-time fMRI neurofeedback of left dorsolateral prefrontal cortex to enhance emotional cognitive control: A randomized controlled trial.

Emotion knowledge is structured in a grid-like coordinate system in the human ventromedial prefrontal cortex.