Academic Articles & Research Papers

Swept source intraoperative OCT angiography

To accurately guide surgical instruments during ophthalmic procedures, some necessary intraoperative depth perception is required, which standard surgical microscopes supply limitedly. Intraoperative optical coherence tomography (iOCT), com...

PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway

Background. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damag...

Early Retinal Microvascular Alterations in Young Type 1 Diabetic Patients without Clinical Retinopathy

The purpose of this study is to identify and quantify preclinical changes with the help of optical coherence tomography angiography (OCTA) within the retinal microcirculation of young type 1 diabetes (T1D) patients without clinical signs of...

Brain perfusion imaging in neonates

Abnormal variations of the neonatal brain perfusion can result in long-term neurodevelopmental consequences and cerebral perfusion imaging can play an important role in diagnostic and therapeutic decision-making. To identify at-risk situati...

Inter-Observer Reliability in Myocardial Blood Flow Measurement Using Rb-82-PET/CT

Background/Objectives: Myocardial perfusion PET/CT, e.g., using Rb-82, enables the measurement of absolute myocardial blood flow (MBF) and, hence, the blood flow reserve, which plays a crucial role in the diagnosis of coronary artery diseas...

Emerging Role of Ferroptosis in the Pathogenesis of Ischemic Stroke: A New Therapeutic Target?

Ischemic stroke is one of the main causes of high morbidity, mortality, and disability worldwide; however, the treatment methods are limited and do not always achieve satisfactory results. The pathogenesis of ischemic stroke is complex, def...

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

Associations of carotid flow velocity with cerebral perfusion and cerebral small vessel disease: a community-based prospective study

Abstract Objectives To explore the associations of carotid artery hemodynamic parameters with cerebral perfusion and cerebral small vessel disease (CSVD) in a healthy population. Methods A total of 654 participants from the Kailuan communit...

Feasibility of one-stop multi-energy dynamic photon-counting perfusion CT for resectable HCC evaluation: lesion detection and histopathological correlations.

Spectral-habitat analysis and perfusion fingerprinting on contrast-enhanced ultrasound for characterizing tumor perfusion in breast lesions.

Protective effects of ceria nanoclusters against delayed paraplegia after spinal cord ischemia

Abstract Spinal cord ischemia reperfusion injury (SCIRI) induced delayed paraplegia is a complex complication of thoracoabdominal aortic surgery. Reactive oxygen species (ROS) play a critical role in the pathogenesis of delayed paraplegia, ...

Role of multilayer flow modulator stents in the treatment of arterial aneurysms

Arterial aneurysms remain a significant public health problem because they often result in death when ruptured; therefore, they require immediate medical treatment. Endovascular aneurysm repair (EVAR) has recently become the primary treatme...

C3a Enhances the Formation of Intestinal Organoids through C3aR1

C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied....

Computer vision applications in vascular surgery: From preoperative mapping to intraoperative flow assessment

Artificial intelligence (AI) and computer vision (CV) are increasingly applied in vascular surgery for preoperative mapping and intraoperative flow/perfusion assessment, with potential to enhance safety and efficiency. However, the extent o...

Fast reconstruction of SMS bSSFP myocardial perfusion images using noise map estimation network (NoiseMapNet): a head-to-head comparison with parallel imaging and iterative reconstruction

BackgroundSimultaneous multi-slice (SMS) bSSFP imaging enables stress myocardial perfusion imaging with high spatial resolution and increased spatial coverage. Standard parallel imaging techniques (e.g., TGRAPPA) can be used for image recon...

Advanced organ protection strategies in aortic arch surgery: A narrative review.

Prospective assessment of intraoperative renal perfusion with transit time flow measurements (TTFM) in deceased and living donor kidney transplantation.

Perioperative blood loss in cardiac surgery: Validation of machine learning-derived clusters.

Generative-Adversarial-Network-Based Image Reconstruction for the Capacitively Coupled Electrical Impedance Tomography of Stroke

This study investigated the potential of machine-learning-based stroke image reconstruction in capacitively coupled electrical impedance tomography. The quality of brain images reconstructed using the adversarial neural network (cGAN) was e...

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation

Abstract Cerebral blood flow is essential for brain function and is governed by cerebral perfusion pressure and physiological mechanisms collectively referred to as cerebral vascular regulation (CVR). Direct measurement of cerebral blood fl...