Academic Articles & Research Papers

TP53 mutation promotes sunitinib resistance in gallbladder cancer via the ARHGEF7-AS2/miR-326/AXL pathway.

Fuzheng Yiai Formula and its Key Components Inhibited PCa by TP53/SLC7A11/GPX4-Induced Ferroptosis.

Minor Proteins Involved in Neuronal Functions in Serum of Patients With Major Mental Disorders According to Proteomic Analysis.

FDX1 suppresses acute myeloid leukemia progression and reverses cuproptosis resistance via the ROS/p53/ME1 axis.

Evaluating the diagnostic value and prospects of genomic and mutational sequencing in malignant transformation of oral leukoplakia

Genomic and mutational sequencing in malignant transformation of oral leukoplakia (OLK) has emergingly gained momentum. In this short communication, we identified 5 retrospective follow-up studies and 5 cross-section comparative studies on ...

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Regenerative therapy for degenerative spine disorders requires the identification of cells that can slow down and possibly reverse degenerative processes. Here, we identify an unanticipated wound-specific notochord sheath cell subpopulation...

Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures

Abstract Background As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productivity can be ...

Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer

Abstract Background Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from oncogenic trans...

Nem tudo que reluz é ouro: desmestificando a interface entre o novo paradigma do desenvolvimento e o novo urbano

O presente estudo teve como objetivo, a partir de uma análise teórica e de revisão bibliográfica, compreender a essência da interface entre o novo paradigma de desenvolvimento (com ênfase no local) e o novo urbano, este que, está alicerçado...

A Benzimidazole-Based N-Heterocyclic Carbene Derivative Exhibits Potent Antiproliferative and Apoptotic Effects against Colorectal Cancer

Background and Objectives: Colorectal cancer (CRC) remains a major global health issue. Although chemotherapy is the first-line treatment, its effectiveness is limited due to drug resistance developed in CRC. To overcome resistance and impr...

Clinical implications of subclonal TP53 mutations in acute myeloid leukemia

The role of subclonal TP53 mutations, defined by a variant allele frequency of 40%, 20%-40% and 40%, 19 had variant allele frequencies between 20%-40% and 18 had frequencies...

Chromosomal Instability in Various Generations of Human Mesenchymal Stem Cells Following the Therapeutic Radiation

Background. Radiotherapy is a crucial treatment for most malignancies. However, it can cause several side effects, including the development of secondary malignancies due to radiation-induced genomic instability (RIGI). The aim of this stud...

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy

Background Over 50% of patients with relapsed or refractory large B-cell lymphoma (r/r LBCL) receiving CD19-targeted chimeric antigen receptor (CAR19) T-cell therapy fail to achieve durable remission. Early identification of relapse or prog...

The miRNA neuroinflammatory biomarkers in COVID-19 patients with different severity of illness

Introduction: The expression of specific miRNAs and their mRNA targets are changed in infectious disease. The aim of this study was to analyze the expression of pro-neuroinflammatory miRNAs, anti-neuroinflammatory miRNAs, and their mRNA tar...

Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage

Abstract Mutation in genes involved in DNA replication continuously disrupt DNA replication and give rise to genomic instability, a critical driver of oncogenesis. To prevent leukemia, immature T lymphocytes with genomic instability often u...

EPIDEMIOLOGICAL ASPECT OF BOVINE VIRAL DIARRHEA VIRUS- II INFECTION IN DAIRY CATTLE

The purpose of this study was to characterize the clinical and virologic features of the mucosal and thrombocytopenic BVDV infection in infected dairy cattle. Strategy of examination included clinical examination of diseased animals, serum ...

Comparative Evaluation of Resting-State fMRI Representations for Schizophrenia Classification Using Deep Learning.

Integrative multiomics-histopathology analysis for breast cancer classification

Abstract Histopathologic evaluation of biopsy slides is a critical step in diagnosing and subtyping breast cancers. However, the connections between histology and multi-omics status have never been systematically explored or interpreted. We...

Deep learning-based MRI model for predicting P53-mutated hepatocellular carcinoma

Abstract Background The P53-mutated Hepatocellular Carcinoma (HCC) is an aggressive variant associated with vascular endothelial growth factor (VEGF) overexpression and increased microvascular density. This study aimed to develop an MRI-bas...