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Showing 4 of 4 academic articles

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease

Erden Eren, Jeannie-Marie Leoutsakos, Juan Troncoso, Constantine G. Lyketsos et al. • Cells (2022)

The hallmarks of Alzheimer’s disease (AD) pathology are senile plaques containing amyloid-beta (Aβ) and neurofibrillary tangles containing hyperphosphorylated tau. Additional pathologies often co-exist, whereas multiple pathogenic mechanism...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells11030436

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts

Camila Fabiani, Camila Fabiani, Silvia S. Antollini, Silvia S. Antollini • Frontiers in Cellular Neuroscience (2019)

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with satu...

DOAJ Open Access (DOAJ) DOI: 10.3389/fncel.2019.00309

Epidemiology and risk factors of dementia

Wiesje M. van der Flier • Journal of Neurology Neurosurgery & Psychiatry (2005)

ementia refers to a syndrome that is characterised by progressive deterioration of cognitive functions.Neuropsychiatric symptoms, such as apathy, agitation, and depression, are also common.With increasing loss of function, a patient is grad...

OPENALEX Open Access DOI: https://doi.org/10.1136/jnnp.2005.082867 PMC: 1765715

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease

Clara Muñoz-Castro, Ayush Noori, Colin G. Magdamo, Zhaozhi Li et al. • Journal of Neuroinflammation (2022)

Abstract Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpopulations of...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12974-022-02383-4