Academic Articles & Research Papers

Mendelian randomization-inspired targeted polyphenol nanoplatform for synergistic osteoarthritis therapy.

Blood pressure and intraocular pressure in the Canadian Longitudinal Study on Aging: a bidirectional Mendelian randomization analysis.

Antihypertensive drug targets and pancreatitis reporting signals: An integrative mendelian randomization and FAERS pharmacovigilance study.

Pharmacovigilance signal detection of rilonacept using FAERS with exploratory Mendelian randomization analysis.

Preventive effects of compound probiotics supplementation on migraine: Mendelian randomization analysis and experimental evidence.

Causal effects of gut microbiota on functional gastrointestinal disorders: a bidirectional Mendelian randomization study.

Single-Cell Immune Cis-eQTL Mendelian Randomization Prioritizes Cell-Type-Resolved Candidate Causal Genes for Endometriosis.

Isoquercetin Attenuates Graves' Disease-Related Thyroid Epithelial Inflammatory Responses: Exploratory Evidence from Network Pharmacology, Mendelian Randomization, and Cellular Validation.

Causal relationship between genetic-predicted uric acid and cervical cancer risk: evidence for nutritional intervention on cervical cancer prevention

IntroductionThe relationship between serum uric acid (SUA) and cervical cancer is inconclusive. This study aims to investigate the causal relationship between SUA levels and cervical cancer incidence, and to evaluate the potential role of n...

Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis

Jian Cheng, Yangfeng Huang Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, School of Medicine,University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of ChinaCorrespond...

Neurotoxicity of PM_2.5-Bound Multi-Pollutant Mixtures in Parkinson’s Disease: Exploring the <i>INPP5D</i>/SHIP1-PI3K-AKT Axis via an Integrative Multi-Omics Study

Accumulating epidemiological evidence links ambient PM2.5 exposure to elevated Parkinson’s disease (PD) risk, yet the neurotoxicity triggered by PM2.5 multi-pollutant mixtures under real co-exposure scenarios remains insufficiently elucidat...

Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses

BackgroundGeneral obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat d...

The critical involvement of monocytes/macrophages in the pathogenesis of primary Sjögren's syndrome: New evidence from Mendelian randomization and single-cell sequencing

Background: Primary Sjögren's syndrome (pSS) stands as a chronic autoimmune disease characterized by an elusive pathogenesis. The synergy of single-cell RNA sequencing and Mendelian randomization (MR) analysis provides an opportunity to com...

Causal analysis between altered levels of interleukins and obstructive sleep apnea

BackgroundInflammation proteins including interleukins (ILs) have been reported to be related to obstructive sleep apnea (OSA). The aims of this study were to estimate the levels for several key interleukins in OSA and the causal effects be...