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LC–MS/MS-guided discovery of japonamides C and D, two new cyclohexadepsipeptides, from the Nicotiana tabacum-derived endophytic fungus Aspergillus japonicus TE-739D

Haisu Wang, Xianwei Hao, Chen Dong, Xiaolong Yuan et al. • Frontiers in Microbiology (2025)

Endophytic fungi belonging to the Aspergillus genus have received substantial attention due to their notable secondary metabolic potential. In this study, chemical investigations using LC–MS/MS-based molecular networking on the endophytic f...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2025.1595569

Prevalence and factors associated with continual opioid use among patients attending methadone clinic at Mwananyamala Hospital, Dar Es Salaam, Tanzania

Asha Shabani Ripanda, Bajarang Bal Lal Srivastava, Said Hamad Vuai, Azan A Nyundo • Forensic Science International: Reports (2019)

Trends of continual drug use while under treatment have been reported worldwide. This paper assesses opioid use among patients receiving treatment in a methadone clinic for opioid addiction. A total of 126 urine samples were analyzed using ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.fsir.2019.100037

Comparative analysis of chemical toxicological studies of pregabalin in neuropathic pain management (review)

Nargiz Parkhatkyzy, Alma Shukirbekova, Zumrad Usmanalieva, Kundyzay Mirzakir et al. • Journal of Pharmacy & Pharmacognosy Research (2026)

Context: The use of pregabalin in neuropathic pain management has been increasingly associated with concerns regarding toxicity, particularly in cases of overdose, misuse, and co-exposure with central nervous system depressants. In parallel...

DOAJ Open Access (DOAJ) DOI: 10.56499/jppres_14.3.2550

Impact of Pressurized Liquid Extraction and pH on Protein Yield, Changes in Molecular Size Distribution and Antioxidant Compounds Recovery from Spirulina

Jianjun Zhou, Min Wang, Celia Carrillo, Zhenzhou Zhu et al. • Foods (2021)

The research aims to extract nutrients and bioactive compounds from spirulina using a non-toxic, environmentally friendly and efficient method—Pressurized Liquid Extraction (PLE). In this work, Response Surface Methodology (RSM)–Central Com...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods10092153

G-Aligner: a graph-based feature alignment method for untargeted LC–MS-based metabolomics

Ruimin Wang, Miaoshan Lu, Shaowei An, Jinyin Wang et al. • BMC Bioinformatics (2023)

Abstract Background Liquid chromatography–mass spectrometry is widely used in untargeted metabolomics for composition profiling. In multi-run analysis scenarios, features of each run are aligned into consensus features by feature alignment ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12859-023-05525-4

A New Strategy for Efficient Screening and Identification of Monoclonal Antibodies against Oncogenic Avian Herpesvirus Utilizing CRISPR/Cas9-Based Gene-Editing Technology

Man Teng, Zi-Yu Zhou, Yongxiu Yao, Venugopal Nair et al. • Viruses (2022)

Marek’s disease virus (MDV) is an important oncogenic α-herpesvirus that induces Marek’s disease (MD), characterized by severe immunosuppression and rapid-onset T-cell lymphomas in its natural chicken hosts. Historically, MD is regarded as ...

DOAJ Open Access (DOAJ) DOI: 10.3390/v14092045