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Differential Remodelling of Endometrial Extracellular Matrix in the Non-Pregnant Uterus of <i>Lagostomus maximus</i> as a Potential Mechanism Underlying Embryonic Death

Francisco Acuña, Gisela Soledad Gualdoni, Francisco Rivollier, Camila Barril et al. • Animals (2025)

During development, the remodelling of fibrillar components of the uterine extracellular matrix (ECM), mediated by the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), plays an essential role in embryonic survival. Prev...

DOAJ Open Access (DOAJ) DOI: 10.3390/ani15040542

Fumaric acid regulates morphine tolerance in bone cancer pain through spinal MrgC receptor modulation

Sijie Liu, Minghao Tang, Jing Zhao, Lulu Zhang et al. • Pakistan Journal of Pharmaceutical Sciences (2026)

Background: Bone cancer pain (BCP) represents a debilitating complication that profoundly impacts patient quality of life and predisposes to psychological comorbidities, including depression and anxiety. Objectives: To investigate the effec...

DOAJ Open Access (DOAJ) DOI: 10.36721/PJPS.2026.39.8.233.1

Identification and Validation of PLOD2 as an Adverse Prognostic Biomarker for Oral Squamous Cell Carcinoma

Yawei Sun, Shuai Wang, Xingwei Zhang, Zhuhao Wu et al. • Biomolecules (2021)

Background: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a key enzyme that catalyzes the hydroxylation of lysine, plays a crucial role in the progression of several solid tumors. However, its spatial expression profile and pr...

DOAJ Open Access (DOAJ) DOI: 10.3390/biom11121842

Automated measurement of CD8+ T-cell distribution at the tumor epithelial–stromal interface is associated with NSCLC immunotherapy benefit and transcriptomic pathways

Patrick Leo, Hauke Kolster, Hartmut Koeppen, Jennifer Giltnane et al. • Journal of Pathology Informatics (2026)

Whereas anti-PD-(L)1 therapies are widely used in cancer treatment, only a subset of patients achieve long-term survival. Companion diagnostics based on PD-L1 expression have limited predictive power for these therapies, motivating developm...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jpi.2026.100688

Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog

Kyung Ho Park, Tae‐Un Kim, Hyun‐Woo Park, Seoung‐Woo Lee et al. • Veterinary Medicine and Science (2023)

Abstract Background Most extramedullary plasmacytomas (EMPs) aresolitary and located in the head and neck region. They may also occur in the visceral parts of the body. Objectives Here, we report a case of oral EMP followed by neoplastic pl...

DOAJ Open Access (DOAJ) DOI: 10.1002/vms3.1086

Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model

Zhen Li, Yannik Gehlen, Yannik Gehlen, Fabian Heizmann et al. • Frontiers in Bioengineering and Biotechnology (2020)

Discogenic low back pain (LBP) is a main cause of disability and inflammation is presumed to be a major driver of symptomatic intervertebral disc degeneration (IDD). Anti-inflammatory agents are currently under investigation as they demonst...

DOAJ Open Access (DOAJ) DOI: 10.3389/fbioe.2020.00583

Utility of Bone Marrow Cell Block in the Diagnosis of Haematological Disorders: A Cross-sectional Study

Hafsa Shabeer, Shankaran Rukmini Niveditha, Thejasvi Krishnamurthy, Gayathri Bilagali Ramdas • Journal of Clinical and Diagnostic Research (2026)

Introduction: The examination of Bone Marrow Aspirate (BMA) smears and Biopsies (BMBx) are well established in the diagnosis of various haematological and non-haematological disorders. While both techniques have unique advantages over the o...

DOAJ Open Access (DOAJ) DOI: 10.7860/JCDR/2026/81391.23576

The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits

Li R, Cui S, Xu Y, Xing J et al. • Journal of Inflammation Research (2018)

Ruijian Li,1&ndash;3,* Sumei Cui,1&ndash;3,* Youshun Xu,4 Junhui Xing,5 Li Xue,1&ndash;3 Yuguo Chen1&ndash;3 1Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; 2Key Laboratory of Emergency and Critical Care Medicine...

DOAJ Open Access (DOAJ)

Poly (acrylic acid)/tricalcium phosphate nanoparticles scaffold enriched with exosomes for cell-free therapy in bone tissue engineering: An in vivo evaluation

Nahid Moradi, Mina Soufi-Zomorrod, Simzar Hosseinzadeh, Masoud Soleimani • BioImpacts (2024)

Introduction: This study aimed to assess the potential of poly (acrylic acid)/tricalcium phosphate nanoparticles (PAA/triCaPNPs) scaffold in terms of biocompatibility and osteoconductivity properties the in-vivo evaluation as well as to inv...

DOAJ Open Access (DOAJ) DOI: 10.34172/bi.2023.27510

A New Strategy for Efficient Screening and Identification of Monoclonal Antibodies against Oncogenic Avian Herpesvirus Utilizing CRISPR/Cas9-Based Gene-Editing Technology

Man Teng, Zi-Yu Zhou, Yongxiu Yao, Venugopal Nair et al. • Viruses (2022)

Marek’s disease virus (MDV) is an important oncogenic α-herpesvirus that induces Marek’s disease (MD), characterized by severe immunosuppression and rapid-onset T-cell lymphomas in its natural chicken hosts. Historically, MD is regarded as ...

DOAJ Open Access (DOAJ) DOI: 10.3390/v14092045

Improved Immunohistochemistry of Mouse Eye Sections Using Davidson&amp;#39;s Fixative and Melanin Bleaching

Anne Longakit, Chloe Hess, Christina Zhang, Catherine Van Raamsdonk • Bio-Protocol (2025)

Immunohistochemistry (IHC) and immunofluorescence (IF) are fundamental molecular biology techniques to assess protein expression. However, the melanin present normally in the eye in the uveal tract (choroid, iris, and ciliary body) and the ...

DOAJ Open Access (DOAJ) DOI: 10.21769/BioProtoc.5510

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease

Clara Muñoz-Castro, Ayush Noori, Colin G. Magdamo, Zhaozhi Li et al. • Journal of Neuroinflammation (2022)

Abstract Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpopulations of...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12974-022-02383-4