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Showing 20 of 42 academic articles

CRISPR/Cas9 for hepatitis B virus infection treatment

Bo Cai, Shixue Chang, Yuhan Tian, Shuai Zhen • Immunity, Inflammation and Disease (2023)

Abstract Hepatitis B virus (HBV) infection remains a global health challenge. Despite the availability of effective preventive vaccines, millions of people are at risk of cirrhosis and hepatocellular carcinoma. Current drug therapies inhibi...

DOAJ Open Access (DOAJ) DOI: 10.1002/iid3.866

CAFs activated by YAP1 upregulate cancer matrix stiffness to mediate hepatocellular carcinoma progression

Wei Yan, Guo-hui Xiao, Li-juan Wang, Yan Zhou et al. • Journal of Translational Medicine (2025)

Abstract Background The stiffness of the matrix is closely related to the progression of hepatocellular carcinoma (HCC). Although direct targeting of stromal rigidity in HCC remains a clinical challenge, cancer-associated fibroblasts (CAFs)...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12967-025-06325-5