Academic Articles & Research Papers

Evodiamine attenuates hyperuricemia-associated gouty arthritis and renal injury through urate-inflammatory axis modulation.

Gut microbiota-mediated uric acid metabolism: Novel insights for developing urate-lowering and anti-gout medications.

Native Entomophages in the Regulation Cameraria ohridella Deschka & Dimic Populations: Potential and Limitations for Control.

Casearia tomentosa fruit extracts exposed larvicidal activity and morphological alterations in Culex quinquefasciatus and Aedes albopictus under in vitro and semi field conditions

Abstract Mosquitoes are notorious insects that transmit a wide range of infectious diseases, including zika, malaria, chikungunya, filariasis, and dengue. The overuse and incorrect application of synthetic pesticides to control mosquitoes h...

Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosisResearch in context

Summary: Background: Ataxia-telangiectasia (A-T) is a rare multisystem disease characterised by neurodegenerative cerebellar ataxia, lung disease, immune deficiency, high cancer risk, and mitochondrial dysfunction. A-T cells demonstrate de...

Hyperuricemia and dementia – a case-control study

Abstract Background There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric acid (SUA) lev...

Gout epidemiology and comorbidities

OBJECTIVE: To review the epidemiology of gout and associated comorbidities. METHODS: We review the key published studies of the epidemiology of gout and associated comorbidities. RESULTS: The prevalence of gout ranged 1-4% worldwide and inc...

Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh

OBJECTIVE: To estimate influenza-associated mortality in Bangladesh in 2009. METHODS: In four hospitals in Bangladesh, respiratory samples were collected twice a month throughout 2009 from inpatients aged ...

Early urate-lowering therapy in gouty arthritis with acute flares: a double-blind placebo controlled clinical trial

Abstract Background Gouty arthritis (GA) is a chronic systemic disease with recurrent acute monoarthritis. In a previous study, a higher incidence of acute flares was observed during the initial marked decrease in serum urate level. Our stu...

Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure

Glaucoma is a leading cause of blindness, affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. It is well established that inefficient aqueous humor (AqH) outflow resulting from s...

Artificial intelligence and machine learning

Abstract Within the last decade, the application of “artificial intelligence” and “machine learning” has become popular across multiple disciplines, especially in information systems. The two terms are still used inconsistently in academia ...