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Melatonin Regulates Lipid Metabolism in Porcine Cumulus–Oocyte Complexes via the Melatonin Receptor 2

Jun-Xue Jin, Jing-Tao Sun, Chao-Qian Jiang, Hong-Di Cui et al. • Antioxidants (2022)

Previous studies suggest that the inclusion of melatonin (MTn) in in vitro maturation protocols improves the developmental competence of oocytes by scavenging reactive oxygen species (ROS). However, the molecular mechanisms integrating mela...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox11040687

THERAPEUTIC EFFECT OF PACLITAXEL LOADED ON GOLD NANOPARTICLES IN TREATMENT OF INDUCED ORAL SQUAMOUS CELL CARCINOMA

Fatma H. El-Didi, Marwa M. Essawy, Sagy L. Asar, Sahar M. El-Sheikh et al. • Alexandria Dental Journal (2019)

INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with high mortality rate. Conventional treatment strategies have improved but remain far from optimal. Cancer research is focused on improving cance...

DOAJ Open Access (DOAJ) DOI: 10.21608/adjalexu.2019.57569

Metabolic modeling-based drug repurposing in Glioblastoma

Claudio Tomi-Andrino, Alina Pandele, Klaus Winzer, John King et al. • Scientific Reports (2022)

Abstract The manifestation of intra- and inter-tumor heterogeneity hinders the development of ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type. Specifically, the reprogramming of cellular metabolism has b...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-022-14721-w

Emerging mutations in envelope protein of SARS-CoV-2 and their effect on thermodynamic properties

Kejie Mou, Mohnad Abdalla, Dong Qing Wei, Muhammad Tahir Khan et al. • Informatics in Medicine Unlocked (2021)

Structural proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are potential drug targets due to their role in the virus life cycle. The envelope (E) protein is one of the structural proteins; plays a critical role in v...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.imu.2021.100675

Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach

Kai Zhao, Yujia Shi, Hon-Cheong So • Pharmaceutics (2022)

Identification of the correct targets is a key element for successful drug development. However, there are limited approaches for predicting drug targets for specific diseases using omics data, and few have leveraged expression profiles fro...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics14020234

Machine learning and applications in microbiology

Stephen J. Goodswen, Joel Barratt, Paul J Kennedy, Alexa Kaufer et al. • FEMS Microbiology Reviews (2021)

To understand the intricacies of microorganisms at the molecular level requires making sense of copious volumes of data such that it may now be humanly impossible to detect insightful data patterns without an artificial intelligence applica...

OPENALEX cc-by-nc DOI: https://doi.org/10.1093/femsre/fuab015 PMC: 8498514