Academic Articles & Research Papers

Complex antiarrhythmic effects of empagliflozin in non-ischemic HFrEF cardiomyocytes.

Human cardiac innervation-on-a-chip platform recapitulates neurocardiac interactions and supports future disease modeling

Abstract The cardiac autonomic nervous system regulates cardiac function through innervation, and dysfunction of the neuronal and cardiovascular crosstalk has been linked to various pathologies. Here, we present a cardiac innervation-on-a-c...

YAP1 reactivation in cardiomyocytes following ECM remodelling contributes to the development of contractile force and sarcomere maturation

Abstract Cardiac diseases are fueled by extracellular matrix (ECM) remodelling. Together with the altered ECM chemical composition, the mechanical turmoil associated with ECM maladaptive remodelling in the pathological heart drives the shut...