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Computational analyses on delineating specificity of 2-hydroxy-3,5-dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins

Dakshinamurthy Sivakumar, Natarajan Hari, Thirunavukkarasu Sivaraman • Bangladesh Journal of Pharmacology (2014)

We have herein computationally examined binding affinities and specificity of 2-hydroxy-3,5-dinitrobenzamide (HDNB), a small chemical molecular BH3-mimetic identified by means of ‘peptidodynmimetic method’, on the BH3-binding grooves of six...

DOAJ Open Access (DOAJ)

A Benzimidazole-Based N-Heterocyclic Carbene Derivative Exhibits Potent Antiproliferative and Apoptotic Effects against Colorectal Cancer

Sarah Al-Nasser, Maha Hamadien Abdulla, Noura Alhassan, Mansoor-Ali Vaali-Mohammed et al. • Medicina (2024)

Background and Objectives: Colorectal cancer (CRC) remains a major global health issue. Although chemotherapy is the first-line treatment, its effectiveness is limited due to drug resistance developed in CRC. To overcome resistance and impr...

DOAJ Open Access (DOAJ) DOI: 10.3390/medicina60091379