Academic Articles & Research Papers

Passive early screening for Alzheimer's disease and related dementias using EHR comorbidity patterns.

Machine learning in cardiovascular medicine: are we there yet?

Artificial intelligence (AI) broadly refers to analytical algorithms that iteratively learn from data, allowing computers to find hidden insights without being explicitly programmed where to look. These include a family of operations encomp...

Machine Learning for Health Services Researchers

Gut Microbiota and Targeted Biomarkers Analysis in Patients With Cognitive Impairment

Gut microbial alteration is closely associated with brain disorders including cognitive impairment (CI). Gut microbes have the potential to predicate the development of diseases. However, the gut microbial markers for CI remain to be elucid...

Application of Machine Learning for Predicting Progression‐Free and Overall Survival in Patients With Renal Cell Carcinoma

ABSTRACT Patient outcomes in advanced renal cell carcinoma (RCC) remain poor, with five‐year survival rates ranging from ~10% to 30%. Early projections of therapeutic outcomes could optimize precision medicine and accelerate drug developmen...

Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry

Summary: Mass cytometry by time-of-flight (CyTOF) is an emerging technology allowing for in-depth characterization of cellular heterogeneity in cancer and other diseases. Unfortunately, high-dimensional analyses of CyTOF data remain quite d...

Machine Learning for Detection and Diagnosis of Disease

Machine learning offers a principled approach for developing sophisticated, automatic, and objective algorithms for analysis of high-dimensional and multimodal biomedical data. This review focuses on several advances in the state of the art...

Endogenous progesterone blurs frontostriatal representations of emotion control in healthy young women.

Identification of immune-associated biomarkers of diabetes nephropathy tubulointerstitial injury based on machine learning: a bioinformatics multi-chip integrated analysis

Abstract Background Diabetic nephropathy (DN) is a major microvascular complication of diabetes and has become the leading cause of end-stage renal disease worldwide. A considerable number of DN patients have experienced irreversible end-st...

Deep Learning-Based Visual Complexity Analysis of Electroencephalography Time-Frequency Images: Can It Localize the Epileptogenic Zone in the Brain?

In drug-resistant epilepsy, a visual inspection of intracranial electroencephalography (iEEG) signals is often needed to localize the epileptogenic zone (EZ) and guide neurosurgery. The visual assessment of iEEG time-frequency (TF) images i...

Source apportionment and stochastic evaluation of soil contamination and human health risks of potentially toxic elements in Nangodi, northern Ghana

Abstract Artisanal and Small-Scale Mining (ASM) is a critical driver of soil contamination in West Africa, yet quantifying the relative contributions of natural and anthropogenic sources remains a major challenge. This study presents an int...

Precise diagnosis of Alzheimer’s disease based on sex-specific gray matter characteristics

IntroductionThere are notable sex differences in the gray matter of Alzheimer’s disease(AD) patients’ brains, but current evidence is insufficient to prove these differences aid diagnosis effectively.MethodsMultivariate analysis of variance...

Comparison of Methods for Assessing Chlamydia trachomatis Transmission Intensity: A Systematic Review.

Virtual CT Myelography: A Patch-Based Machine Learning Model to Improve Intraspinal Soft Tissue Visualization on Unenhanced Dual-Energy Lumbar Spine CT

Background: Distinguishing between the spinal cord and cerebrospinal fluid (CSF) non-invasively on CT is challenging due to their similar mass densities. We hypothesize that patch-based machine learning applied to dual-energy CT can accurat...

Dynamic Monitoring of Thyroid-Stimulating Hormone Receptor Antibody and Extraocular Muscle Thickness: A Clinical Risk Stratification Model for Recurrence Risk Post-Glucocorticoid Therapy in TED Patients

Yaling Li, Xiuhong Yang, Shuli Hu Department of Intensive Care Unit, Wuhan No. 1 Hospital, Wuhan, 430022, People’s Republic of ChinaCorrespondence: Shuli Hu, Department of Intensive Care Unit, Wuhan No. 1 Hospital, No. 215 Zhongshan Avenue,...

Introduction to machine learning: k-nearest neighbors

Machine learning techniques have been widely used in many scientific fields, but its use in medical literature is limited partly because of technical difficulties. k-nearest neighbors (kNN) is a simple method of machine learning. The articl...

Development and web-based implementation of a machine learning model for predicting one-year adverse outcomes in acute ischaemic stroke

BackgroundThis study aimed to develop an interpretable and clinically applicable machine learning prediction model to assess the risk of adverse outcomes within one year following acute ischaemic stroke, and to establish a corresponding web...

Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites

Abstract Matrix Metalloproteases (MMPs) are an important family of proteases that play crucial roles in key cellular and disease processes. Therefore, MMPs constitute important targets for drug design, development and delivery. Advanced pro...

Machine learning in polymer informatics

Abstract Polymers have been widely used in energy storage, construction, medicine, aerospace, and so on. However, the complexity of chemical composition and morphology of polymers has brought challenges to their development. Thanks to the i...

Leveraging Cloud Technology for Personalized Multiple Sclerosis Care: A Comprehensive Data Management and Visualization Approach

This project develops a cloud-based solution for securely managing clinical data and patient-reported outcomes (PROMs) for multiple sclerosis (MS) patients. Utilizing REDCap for data collection, we incorporated clinical outcomes and PROMs f...