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Anti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer

Lilla Bűdi, Dániel Hammer, Rita Varga, Veronika Müller et al. • Pathology and Oncology Research (2025)

ObjectivesSpingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circ...

DOAJ Open Access (DOAJ) DOI: 10.3389/pore.2024.1611929

CSR and CEO’s Moral Reasoning in the Automotive Industry in the Era of COVID-19

Beatriz Garcia-Ortega, Javier Galan-Cubillo, Blanca de-Miguel-Molina • SAGE Open (2022)

This paper assesses whether and to which extent the COVID-19 pandemic, which represents a scenario of high moral intensity, is influencing the moral reasoning of top CEOs (chief executive officers) in the paradigmatic case of the automotive...

DOAJ Open Access (DOAJ) DOI: 10.1177/21582440221097377

Non-traumatic Causes of Brown-sequard Syndrome: A Case Series and Clinical Update With Systematic Review

Vaner Köksal, Mahmoud Osama, Mohammed Ali Alvi • Iranian Journal of Neurosurgery (2021)

Background and Importance: Brown-Sequard Syndrome (BSS) is a rare neurological condition resulting from a hemisection injury to or unilateral compression on the spinal cord. The common causes of BSS that are amenable to be treated surgicall...

DOAJ Open Access (DOAJ)

The impact of the Affordable Care Act on patient coverage and access to care: perspectives from FQHC administrators in Arizona, California and Texas

Angelo Ercia • BMC Health Services Research (2021)

Abstract Background The Affordable Care Act (ACA) enabled millions of people to gain coverage that was expected to improve access to healthcare services. However, it is unclear the extent of the policy’s impact on Federally Qualified Health...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12913-021-06961-9

Changes in daily living dependency and incident depressive symptoms among older individuals: findings from four prospective cohort studies

Hongwei Liu, Juxiang Yang, Gang Song, Minheng Zhang et al. • BMJ Mental Health (2025)

Background With rapid population ageing, depressive symptoms in older adults have become a pressing public health concern. While functional dependency is a known risk factor, the impact of changes in dependency over time remains unclear.Obj...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjment-2025-301749

Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models

Alfonso Varela-López, José M. Romero-Márquez, María D. Navarro-Hortal, César L. Ramirez-Tortosa et al. • Experimental Gerontology (2023)

The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of a...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2023.112221

Association of negative opinions towards telepsychiatry with its prior use and the level of geriatric psychiatry care among nursing home stakeholders

S Pirbay, MD, S Abou Kassm, MD, MPH, C Di-Maggio, MD, F Naudet, MD, PhD et al. • Archives of Gerontology and Geriatrics Plus (2025)

Objectives: Despite the benefits of geriatric telepsychiatry, the lack of support from the staff remains one of the major challenges it faces. We wanted to explore whether negative opinions towards telepsychiatry in nursing home (NH) stakeh...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.aggp.2025.100150

PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway

Liwei Wu, Qiang Yu, Ping Cheng, Chuanyong Guo • PPAR Research (2021)

Background. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damag...

DOAJ Open Access (DOAJ) DOI: 10.1155/2021/6626295

Effective analysis of neurotoxicity and mechanisms of dioctyl terephthalate using network toxicology

Hao Tang, Ting Qin, Zhiwen Yan, Changqing Li et al. • Frontiers in Neuroscience (2026)

ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mec...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnins.2026.1783807

Using Wearable Devices to Examine the Associations of Sedentary Behavior with Perceived and Performance Fatigability Among Older Adults: The Study of Muscle, Mobility and Aging (SOMMA)

Reagan E. Garcia, Anne B. Newman, Eileen Johnson, Yujia Susanna Qiao et al. • Sensors (2025)

Fatigability, a phenotype of poor energy regulation, is associated with lower physical activity in older adults, but independent associations with sedentary behavior are unknown. We examined whether sedentary behavior was associated with fa...

DOAJ Open Access (DOAJ) DOI: 10.3390/s25092722

Nutritional status, literacy, and risk factors of malnutrition in the population over 50 years of age - findings from the SHARE project

Tereza Vágnerová, Olga Dvořáčková, Eva Topinková • Clinical Nutrition Open Science (2024)

Summary: Background & Aims: The transition from middle age to old age (from adults aged 50–55 years to older seniors aged 75–80 years) represents a critical period in terms of changes in body composition, i.e., increase in body fat per...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nutos.2024.01.006

Associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older adults

Emi Miki, Risa Kawabata • Cadernos Brasileiros de Terapia Ocupacional (2020)

This study aimed to investigate the associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older Japanese adults by examining the correlations between the Canadian Occup...

DOAJ Open Access (DOAJ) DOI: 10.4322/2526-8910.ctoAO2096

Broca’s biases in modern aphasiology

Silvia Martínez-Ferreiro, Monica I. Norvik, Monica I. Norvik • Frontiers in Human Neuroscience (2026)

Broca’s description of aphemia signals the emergence of aphasiology as a discipline. It also marks the beginning of a long tradition of studies of right-handed patients (“Nous parlons avec l’hémisphère gauche”) with lesions in the inferior ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnhum.2026.1783073

<i>Sechium edule</i> var. <i>nigrum spinosum</i> (Chayote) Increases the mRNA Expression of Genes Encoding Sirtuins in Older Adults with Type 2 Diabetes Mellitus

Graciela Gavia-García, David Hernández-Álvarez, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez et al. • Molecules (2026)

Consumption of Sechium edule var. nigrum spinosum has antioxidant and hypoglycemic effects. Regarding the former, certain signaling pathways that influence these effects have already been proposed; however, the underlying molecular mechanis...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules31071182

Decreased Daily Melatonin Levels in Women with Systemic Lupus Erythematosus - A Short Report

Ralitsa Robeva, Georgi Kirilov, Dobromir Tanev, Analia Tomova et al. • Balkan Medical Journal (2013)

Background: The neuroendocrine system is known to influence immunity, but the precise interactions between different hormones and autoimmune disorders remain obscure. Aims: The present study aimed to investigate the role of daily serum ...

DOAJ Open Access (DOAJ) DOI: 10.5152/balkanmedj.2013.8064

Having More Daughters Independently Predicts Home Discharge in Stroke Patients Admitted to Inpatient Rehabilitation Ward

Shiau-Fu Hsieh, Kuo-Liong Chien, Chu-Hao Weng, Yi-Ping Chiang • International Journal of Gerontology (2017)

Background: The predictors for failure of home discharge after post-acute inpatient stroke rehabilitation need investigation. Methods: With this retrospective case-control study conducted in a stroke rehabilitation unit in one tertiary hosp...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ijge.2017.07.005