Reset
Showing 20 of 402 academic articles

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

Joachim Kloehn, Rebecca D. Oppenheim, Ghizal Siddiqui, Pieter-Jan De Bock et al. • BMC Biology (2020)

Abstract Background Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at leas...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12915-020-00791-7

Multi-omics for studying and understanding polar life

M. S. Clark, J. I. Hoffman, L. S. Peck, L. Bargelloni et al. • Nature Communications (2023)

Abstract Polar ecosystems are experiencing amongst the most rapid rates of regional warming on Earth. Here, we discuss ‘omics’ approaches to investigate polar biodiversity, including the current state of the art, future perspectives and rec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-023-43209-y

Translating research on seed dormancy and germination from Arabidopsis to temperate cereals to control pre-harvest sprouting

Renqiang Li, Muhammad Usama Hameed, Koen Geuten • Frontiers in Plant Science (2026)

From slow, non-uniform germination to pre-harvest sprouting (PHS), both extremes of seed dormancy have posed challenges for plant breeders. Because this trait needs to be genetically tuned in relation to environmental cues, controlling the ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpls.2026.1763984

A Review of Thermal Safety and Management of Second-Life Batteries: Cell Screening, Pack Configuration and Health Estimation

Md Imran Hasan, Gang Lei, Dylan Lu, Pablo Poblete Durruty • Batteries (2026)

Electric vehicle (EV) adoption is generating a rapidly increasing stream of retired lithium-ion batteries for second-life deployment. However, thermal safety concerns continue to limit their reuse. This paper reviews second-life battery (SL...

DOAJ Open Access (DOAJ) DOI: 10.3390/batteries12030099

Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges

Kirsten M. Wright, Janis McFerrin, Armando Alcázar Magaña, Armando Alcázar Magaña et al. • Frontiers in Nutrition (2022)

Botanical products are frequently sold as dietary supplements and their use by the public is increasing in popularity. However, scientific evaluation of their medicinal benefits presents unique challenges due to their chemical complexity, i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2021.799137

Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer

Youfeng Shen, Kaixiang Xu, Zaimei Yuan, Jianxiong Guo et al. • Journal of Translational Medicine (2017)

Abstract Background Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from oncogenic trans...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12967-017-1327-0

Epigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging

Pei-Lun Kuo, Ann Zenobia Moore, Frank R. Lin, Frank R. Lin et al. • Frontiers in Aging Neuroscience (2021)

Objectives: Age-related hearing loss (ARHL) is highly prevalent among older adults, but the potential mechanisms and predictive markers for ARHL are lacking. Epigenetic age acceleration has been shown to be predictive of many age-associated...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnagi.2021.790926

Using Wearable Devices to Examine the Associations of Sedentary Behavior with Perceived and Performance Fatigability Among Older Adults: The Study of Muscle, Mobility and Aging (SOMMA)

Reagan E. Garcia, Anne B. Newman, Eileen Johnson, Yujia Susanna Qiao et al. • Sensors (2025)

Fatigability, a phenotype of poor energy regulation, is associated with lower physical activity in older adults, but independent associations with sedentary behavior are unknown. We examined whether sedentary behavior was associated with fa...

DOAJ Open Access (DOAJ) DOI: 10.3390/s25092722

Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits

Mateus H. Gouveia, Amy R. Bentley, Hampton Leonard, Karlijn A. C. Meeks et al. • Scientific Reports (2021)

Abstract Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specif...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-021-83450-3

miRNA-mediated loss of m6A increases nascent translation in glioblastoma.

John P Zepecki, David Karambizi, J Eduardo Fajardo, Kristin M Snyder et al. • PLoS Genetics (2021)

Within the glioblastoma cellular niche, glioma stem cells (GSCs) can give rise to differentiated glioma cells (DGCs) and, when necessary, DGCs can reciprocally give rise to GSCs to maintain the cellular equilibrium necessary for optimal tum...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pgen.1009086

Genetic impact of non-consanguineous marriages in Saudi Arabia.

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie et al. • Journal of Biochemical and Clinical Genetics (2022)

Background: Physicians and geneticists face challenges in making accurate diagnoses during clinical evaluations; affecting patients and clinicians. The aim of this study was to estimate the hit rate of the non-consanguineous population. Mor...

DOAJ Open Access (DOAJ) DOI: 10.24911/JBCGenetics/183-1664872492

Building evidences in Public Health Emergency Preparedness (“BePHEP” Project)—a systematic review

Michelangelo Mercogliano, Gloria Spatari, Chiara Noviello, Francesca Di Serafino et al. • International Journal for Equity in Health (2025)

Abstract Introduction Humanitarian crises exacerbate the vulnerability of already fragile healthcare systems and significantly increase the risk of infectious disease outbreaks in low- and middle-income countries (LMICs). This systematic re...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12939-025-02382-w

Autism Spectrum Disorder and collective catering service: results of the pilot study FOOD-AUT

Maria Vittoria Conti, Sara Santero, Chiara Breda, Sara Basilico et al. • Frontiers in Nutrition (2024)

ObjectiveIndividuals with Autism Spectrum Disorder (ASD) often exhibit a low dietary diversity due to food selectivity that leads them to a marked preference for high-energy-density food, exposing them to risk of malnutrition. Despite these...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnut.2023.1298469

TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease

Eva Steinke, Eva Steinke, Eva Steinke, Olaf Sommerburg et al. • Frontiers in Medicine (2023)

BackgroundLung disease as major cause for morbidity in patients with cystic fibrosis (CF) starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype but other contributing factors are not well delineated...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2022.1034290

Progress and Perspective of CRISPR‐Cas9 Technology in Translational Medicine

Ruixuan Zheng, Lexiang Zhang, Rokshana Parvin, Lihuang Su et al. • Advanced Science (2023)

Abstract Translational medicine aims to improve human health by exploring potential treatment methods developed during basic scientific research and applying them to the treatment of patients in clinical settings. The advanced perceptions o...

DOAJ Open Access (DOAJ) DOI: 10.1002/advs.202300195

The Family Wellness Program: a bench to bedside translation of behavioral and social science research into a clinical program for intimate partners of warfighters following traumatic brain injury

Tracey A. Brickell, Tracey A. Brickell, Tracey A. Brickell, Tracey A. Brickell et al. • Frontiers in Health Services (2025)

This report details a bench to bedside translation of behavioral and social science research into a clinical program as a result of a collaboration between two United States Defense Health Agency Centers of Excellence for warfighter traumat...

DOAJ Open Access (DOAJ) DOI: 10.3389/frhs.2025.1575781

Translational research in health technologies: A scoping review

Nadja N. V. Mayrink, Luís Alcoforado, Arthur Chioro, Felipe Ricardo dos Santos Fernandes et al. • Frontiers in Digital Health (2022)

Introduction: The current debate on the process of technological innovation points out as a challenge for universities consolidation of competencies that allow the generation and transfer of knowledge to society. The Translational Research ...

OPENALEX cc-by DOI: https://doi.org/10.3389/fdgth.2022.957367 PMC: 9385029