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Investigating the genetic makeup of the major histocompatibility complex (MHC) in the United Arab Emirates population through next-generation sequencing

Nour al dain Marzouka, Halima Alnaqbi, Amira Al-Aamri, Guan Tay et al. • Scientific Reports (2024)

Abstract The Human leukocyte antigen (HLA) molecules are central to immune response and have associations with the phenotypes of various diseases and induced drug toxicity. Further, the role of HLA molecules in presenting antigens significa...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-024-53986-1

Poly (ADP-ribose) Polymerase Promoter Hypermethylation Predispose Females to Breast Cancer

Hussein Sabit, Shaimaa Nazir, Shimaa Abdel-Ghany, Osama A. Said et al. • Asian Pacific Journal of Cancer Biology (2019)

Being the most common cause of female deaths worldwide, breast cancer (BC) is intensively studied over the last two decades. In the present investigation, we evaluated the promoter methylation of three cancer-related genes; PARP-1, p21, and...

DOAJ Open Access (DOAJ) DOI: 10.31557/apjcb.2019.4.1.1-5

KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors

Dan Lu, Yuan Chen, Min Jiang, Jie Wang et al. • Nature Communications (2023)

Abstract KRAS mutations are broadly recognized as promising targets for tumor therapy. T cell receptors (TCRs) can specifically recognize KRAS mutant neoantigens presented by human lymphocyte antigen (HLA) and mediate T cell responses to el...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-023-42010-1

In Vitro Evaluation of Polihexanide, Octenidine and NaClO/HClO-Based Antiseptics against Biofilm Formed by Wound Pathogens

Grzegorz Krasowski, Adam Junka, Justyna Paleczny, Joanna Czajkowska et al. • Membranes (2021)

Chronic wounds complicated with biofilm formed by pathogens remain one of the most significant challenges of contemporary medicine. The application of topical antiseptic solutions against wound biofilm has been gaining increasing interest a...

DOAJ Open Access (DOAJ) DOI: 10.3390/membranes11010062

Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi et al. • Scientific Reports (2017)

Abstract For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-017-06872-y

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

Kevin Achberger, Christopher Probst, Jasmin Haderspeck, Sylvia Bolz et al. • eLife (2019)

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.46188

Comparative Phytochemical Analysis of the Aerial Parts of <i>Pelargonium radula</i> and <i>Geranium macrorrhizum</i> Cultivated in Bulgaria Using GC-MS and HPLC

Debora Sabotinova, Petya Boycheva, Nadezhda Ivanova, Velichka Andonova et al. • Pharmaceuticals (2026)

Background: Geraniaceae species are widely used in traditional medicine. Pelargonium radula and Geranium macrorrhizum are aromatic medicinal plants traditionally used in Bulgaria for their antimicrobial, anti-inflammatory, and wound-healing...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph19030346

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells

Xinbo Wang, Jiaying Miao, Sizhen Wang, Rongxi Shen et al. • Molecular Cancer (2022)

Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features. Me...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12943-022-01596-8

Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis

Mengqiang Fan, Peijian Tong, Li Yan, Ting Li et al. • BMC Medicine (2023)

Abstract Background Articular injection of mesenchymal stem cells (MSCs) has been applied to treat knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated whether an articular inflammatory microenviro...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12916-023-02923-6

A rationale for a museum of health

Farzaneh Yousefi, Iraj I. Nabipour, Alireza Raeisi, Majid Assadi • Iranian South Medical Journal (2015)

The museum of health is a place that presents health science and human body and any other subjects that can affect human health. In this museum visitors can learn the mechanisms and functions of human body and learn how to protect and take ...

DOAJ Open Access (DOAJ)

Prenatal diagnosis of mosaicism for double aneuploidy of 47,XXY and trisomy 7 (48,XXY,+7) at amniocentesis in a pregnancy with a favorable outcome

Chih-Ping Chen, Hsiu-Ting Tsai, Schu-Rern Chern, Peih-Shan Wu et al. • Taiwanese Journal of Obstetrics & Gynecology (2021)

Objective: We present prenatal diagnosis of mosaicism for double aneuploidy of 47, XXY and trisomy 7 (48,XXY,+7) at amniocentesis in a pregnancy with a favorable outcome. Case report: A 33-year-old woman underwent amniocentesis at 17 weeks ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.tjog.2021.03.029

Accomplishments in genome‐scale in silico modeling for industrial and medical biotechnology

Caroline B. Milne, Pan‐Jun Kim, James A. Eddy, Nathan D. Price • Biotechnology Journal (2009)

Driven by advancements in high-throughput biological technologies and the growing number of sequenced genomes, the construction of in silico models at the genome scale has provided powerful tools to investigate a vast array of biological sy...

OPENALEX Open Access DOI: https://doi.org/10.1002/biot.200900234 PMC: 3160784

Regulatory requirements for the registration of generic medicines and format of drug dossiers: procedures in Sri Lanka in comparison with selected regulatory authorities

D. Thambavita, P. Galappatthy, R. L. Jayakody • Journal of Pharmaceutical Policy and Practice (2018)

Background The regulatory requirements for approval of generic medicines and the format of compiling drug dossiers vary among regulatory authorities. The variation is particularly wide between High-income countries (HIC) and lower and middl...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40545-018-0141-2

Parents’ Perceptions of the Problems in Children With Autism Spectrum Disorders: A Qualitative Study

Masume Zareei, Seyed Abolfazl Tohidast, Masoomeh Salmani • Iranian Rehabilitation Journal (2022)

Objectives: Parents of children with autism spectrum disorder (ASD) have valuable experiences of the possible developmental problems and other issues of their children as the primary caregivers. The present study aimed to obtain proper info...

DOAJ Open Access (DOAJ)

The Effectiveness of some Communicative Strategies for Developing Speaking Skills among ESRI post Graduate Students at University of Sadat City

هاجر احمد نصار • Maǧallaẗ Kulliyyaẗ Al-Tarbiyyẗ Ǧamiʿaẗ Banhā (2025)

Despite the unparalleled characteristics of speaking skill and its vital role in EFL learning process specifically for post graduate students, it does not receive the attention it deserves due to the lack of everyday communication. So the a...

DOAJ Open Access (DOAJ) DOI: 10.21608/jfeb.2024.306688.1974