Academic Articles & Research Papers

Developments in Exploring Fungal Secondary Metabolites as Antiviral Compounds and Advances in HIV-1 Inhibitor Screening Assays

The emergence of drug-resistant Human Immunodeficiency Virus-1 strains against anti-HIV therapies in the clinical pipeline, and the persistence of HIV in cellular reservoirs remains a significant concern. Therefore, there is a continuous ne...

Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Abstract For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effec...

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

Implications of Isoprostanes and Matrix Metalloproteinase-7 Having Potential Role in the Development of Colorectal Cancer in Males

BackgroundColorectal cancer (CRC) is the third most common type of cancer and leading cause of death worldwide. Major risk factors involved in the development of CRC are increased dietary sources, genetics, and increasing age. Purpose of th...

Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis

Abstract Background Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates protein stabil...

Effect of Glycyrrhiza uralensis crude water extract on the expression of Nitric Oxide Synthase 2 gene during myogenesis

Glycyrrhiza uralensis is a traditional herbal medicine with significant bioactivity. This study investigated the effect of G. uralensis crude water extract (GU-CWE) on nitric oxide synthase 2 (NOS2) expression during myogenesis. GU-CWE trea...

PRODUCTION OF L-TRYPTOPHAN BY MUTANTS OF CORYNEBACTERIUM GLUTAMICUM

L-Tryptophan, is one of the amino acids, also is one of the 9 essential amino acids of human which cannot be synthesized internally by him, microbial production is the main method for obtaining tryptophan for commercial uses. Typical microo...

Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis

Abstract Background Articular injection of mesenchymal stem cells (MSCs) has been applied to treat knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated whether an articular inflammatory microenviro...

Medical Biotechnology

Regulatory requirements for the registration of generic medicines and format of drug dossiers: procedures in Sri Lanka in comparison with selected regulatory authorities

Background The regulatory requirements for approval of generic medicines and the format of compiling drug dossiers vary among regulatory authorities. The variation is particularly wide between High-income countries (HIC) and lower and middl...

Benefits of Using Early Warning Scores - A Systematic Review

The Early Warning Scores (EWSs) are tools for bedside evaluation based on five physiological parameters: systolic pressure, pulse, respiratory rate, body temperature and AVPU (alert, voice, pain, unresponsive) score. EWSs have been used in ...

How Does the Diversity of Divers Affect the Design of Citizen Science Projects?

Divers have widely participated in citizen science (CS) projects and are one of the main groups of marine citizen scientists. However, there is little knowledge about profiles of, and incentives for potential divers to join CS projects. To ...

‘Incense is the one that keeps the air fresh’: indoor air quality perceptions and attitudes towards health risk

Abstract Background Air pollution is of significant environmental and public health concern globally. While much research has historically focused on outdoor air pollution, indoor air pollution has been relatively under-explored despite its...

The Effectiveness of some Communicative Strategies for Developing Speaking Skills among ESRI post Graduate Students at University of Sadat City

Despite the unparalleled characteristics of speaking skill and its vital role in EFL learning process specifically for post graduate students, it does not receive the attention it deserves due to the lack of everyday communication. So the a...

Dialogue: Theorizing Difference in Communication Studies

Index Foreword: Entering into Dialogue - Julia T. Wood Introduction: Texts and Contexts of Dialogue - Rob Anderson, Leslie A. Baxter, and Kenneth N. Cissna PART I: EXPLORING THETERRITORIES OF DIALOGUE 1. Relationships Among Philosphers of D...

The impact of the student-supervisor relationship on graduate student mental health: An integrative review

In recent years, the mental health of graduate students has become a prominent concern in higher education, with many students experiencing elevated levels of stress, anxiety, depression, burnout, and psychological distress. These challenge...

The spiritual experience of Chinese Muslim minorities post-1998 reformation: A study of Chinese Muslims becoming Indonesians

This article describes a new method of viewing a historical phenomenon based on its social significance. This method enabled the classification and analysis of a group in a context simultaneously and chronologically. Using historical phenom...

Developing and defining core climate and environmental epidemiology competencies for field epidemiology training programs in the Eastern Mediterranean Region: a Delphi study

BackgroundClimate change, environmental degradation, and chemical hazards increasingly shape population health risks, particularly in the Eastern Mediterranean Region (EMR), where water scarcity, rapid urbanization, conflict, and fragile he...

Handbook of Mobile Communication Studies

Experts analyze how mobile communication is changing daily life and local culture around the world, in both industrialized and developing countries. Mobile communication has become mainstream and even omnipresent. It is arguably the most su...

Human Pacemakers and Experiential Reading

This paper applies an embodied perspective to the study of reading and has a two-fold aim: (i) to discuss how reading is best understood in terms of cultural-cognitive performance that involves living bodies who actively engage with reading...