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Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites

Yanan Wang, Jiangning Song, Tatiana T. Marquez-Lago, André Leier et al. • Scientific Reports (2017)

Abstract Matrix Metalloproteases (MMPs) are an important family of proteases that play crucial roles in key cellular and disease processes. Therefore, MMPs constitute important targets for drug design, development and delivery. Advanced pro...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-017-06219-7

The challenge of studying perovskite solar cells’ stability with machine learning

Paolo Graniero, Paolo Graniero, Mark Khenkin, Hans Köbler et al. • Frontiers in Energy Research (2023)

Perovskite solar cells are the most dynamic emerging photovoltaic technology and attracts the attention of thousands of researchers worldwide. Recently, many of them are targeting device stability issues–the key challenge for this technolog...

DOAJ Open Access (DOAJ) DOI: 10.3389/fenrg.2023.1118654

Exploring the application and challenges of fNIRS technology in early detection of Parkinson’s disease

Pengsheng Hui, Yu Jiang, Jie Wang, Congxiao Wang et al. • Frontiers in Aging Neuroscience (2024)

BackgroundParkinson’s disease (PD) is a prevalent neurodegenerative disorder that significantly benefits from early diagnosis for effective disease management and intervention. Despite advancements in medical technology, there remains a cri...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnagi.2024.1354147

Application of MRI-Based Radiomics in Preoperative Prediction of NF2 Alteration in Intracranial Meningiomas

Shuchen Sun, Shuchen Sun, Shuchen Sun, Leihao Ren et al. • Frontiers in Oncology (2022)

PurposeThis study aimed to investigate the feasibility of predicting NF2 mutation status based on the MR radiomic analysis in patients with intracranial meningioma.MethodsThis retrospective study included 105 patients with meningiomas, incl...

DOAJ Open Access (DOAJ) DOI: 10.3389/fonc.2022.879528

When more is not always better: exercise dose and children’s cognitive development from an interpretable machine learning perspective

Wenbing Zhu, Weiqiang Zhang, Liming Yong • Frontiers in Psychiatry (2026)

BackgroundExercise intervention has been associated with cognitive development in children. However, current study methods have not clarified the potential nonlinear association between exercise dosage and cognitive ability, and interpretab...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyt.2026.1908580

Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach

Kai Zhao, Yujia Shi, Hon-Cheong So • Pharmaceutics (2022)

Identification of the correct targets is a key element for successful drug development. However, there are limited approaches for predicting drug targets for specific diseases using omics data, and few have leveraged expression profiles fro...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics14020234

Synergistic multi-altimeter for estimating water level in the coastal zone of Beibu Gulf using SEL, ALES + and BFAST algorithms

Jiaoling Qin, Jiaoling Qin, Sunzhe Li, Sunzhe Li et al. • Frontiers in Marine Science (2023)

Accurately monitoring and predicting the large-scale dynamic changes of water levels in coastal zones is essential for its protection, restoration and sustainable development. However, there has been a challenge for achieving this goal usin...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmars.2022.1113387

Aerosol Optical Depth Retrieval from MODIS Using a Physically Informed Machine Learning Framework

Tianchen Liang, Linqing Zou, Qiaoning He, Lin Sun • Remote Sensing (2026)

Retrieving aerosol optical depth (AOD) over land remains challenging because the relatively weak aerosol signal in top-of-atmosphere (TOA) observations must be separated from strong and spatially heterogeneous surface reflectance. Here, we ...

DOAJ Open Access (DOAJ) DOI: 10.3390/rs18172862

Probabilistic daily runoff forecasting in high-altitude cold regions using a hybrid model combining DBO and transformer variants

Qiying Yu, Wenzhong Li, Yungang Bai, Zhenlin Lu et al. • Journal of Hydrology: Regional Studies (2025)

Study Area: The Tailan River Basin in the Aksu region and the Yulong Kashi River in the Hotan River Basin of Xinjiang are located at respective geographical coordinates of 80°21'44'' to 81°10'14'' E, 40°41'41'' to 42°15'13'' N, and 77.25° t...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ejrh.2025.102311

Integrated Bioinformatics Analysis and Experimental Verification of Immune Cell Infiltration and the Related Core Genes in Ulcerative Colitis

Zhao D, Qin D, Yin L, Yang Q • Pharmacogenomics and Personalized Medicine (2023)

Danya Zhao,1 Danping Qin,2 Liming Yin,3 Qiang Yang4 1The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of Gastroenterology, The First Affiliated Hospital of Zheji...

DOAJ Open Access (DOAJ)

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

Lei Liu, Taiheng Ma, Qi Liu, He Zhu et al. • Advanced Science (2026)

ABSTRACT Dysregulated protein glycosylation is a hallmark of cancer, and systematic investigation of glycosylation patterns is crucial for identifying biomarkers. However, current glycoproteomic studies are constrained by the limited quanti...

DOAJ Open Access (DOAJ) DOI: 10.1002/advs.202516299

A Prediction Model for Spot LNG Prices Based on Machine Learning Algorithms to Reduce Fluctuation Risks in Purchasing Prices

Sun-Feel Yang, So-Won Choi, Eul-Bum Lee • Energies (2023)

The ongoing Russia–Ukraine conflict has exacerbated the global crisis of natural gas supply, particularly in Europe. During the winter season, major importers of liquefied natural gas (LNG), such as South Korea and Japan, were directly affe...

DOAJ Open Access (DOAJ) DOI: 10.3390/en16114271

A Transformer-Based Approach for Efficient Geometric Feature Extraction from Vector Shape Data

Longfei Cui, Xinyu Niu, Haizhong Qian, Xiao Wang et al. • Applied Sciences (2025)

The extraction of shape features from vector elements is essential in cartography and geographic information science, supporting a range of intelligent processing tasks. Traditional methods rely on different machine learning algorithms tail...

DOAJ Open Access (DOAJ) DOI: 10.3390/app15052383