Academic Articles & Research Papers

Guizhi-Shaoyao-Zhimu decoction alleviates gastrointestinal acute graft-vs.-host disease and suppresses FGF2/PI3K/Akt signaling: insights from network pharmacology, WGCNA, molecular docking, and animal experiment.

Deep learning and metaheuristic optimization for predicting drug release from nanocarrier systems: a data-driven framework for formulation development.

Assessment of the learning environment among medical students at Tabuk University, Saudi Arabia: a cross-sectional study

BackgroundThe learning environment (LE) is integral to medical students’ academic performance, emotional well-being, and professional development. Students’ perceptions of their learning environment provide valuable insights for identifying...

Effects of long-term exposure to air pollutant mixture on blood pressure in typical areas of North China

Background: Studies about the combined effects of gaseous air pollutants and particulate matters are still rare. Objectives: This study was performed based on baseline survey of the Diverse Life-Course Cohort in the Beijing-Tianjin-Hebei (B...

Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: a Prospective Pilot Study

Introduction: Coagulation and fibrinolysis remain sparsely addressed with regards to acute respiratory distress syndrome (ARDS). We hypothesized that ARDS development might be associated with changes in plasma coagulation and fibrinolysis. ...

Associations of subclinical autistic-like traits with brain structural variation using diffusion tensor imaging and voxel-based morphometry

Abstract Background Previous case–control studies of autistic spectrum disorder (ASD) have identified altered brain structure such as altered frontal and temporal cortex volumes, or decreased fractional anisotropy (FA) within the inferior ...

Evaluation of the implementation of International Classification of Diseases, 11th revision for morbidity coding: Rationale and study protocol

International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) has been used for many years in many countries to manage health information. The World Health Organization (WHO) will soon replace ICD-...

Teaching evaluation of “traditional Chinese medicine” course for eight-year undergraduates of Peking Union Medical College

Objective To explore the role of teaching evaluation in the practice of “traditional Chinese medicine” course for eight-year undergraduates of Peking Union Medical College. Methods With a secret questionnaire survey, statistics and summariz...

The Balanced Opioid Initiative: protocol for a clustered, sequential, multiple-assignment randomized trial to construct an adaptive implementation strategy to improve guideline-concordant opioid prescribing in primary care

Abstract Background Rates of opioid prescribing tripled in the USA between 1999 and 2015 and were associated with significant increases in opioid misuse and overdose death. Roughly half of all opioids are prescribed in primary care. Althoug...

Data resource profile: a nationally representative linked pregnancy cohort in Canada integrating clinical, social, and environmental data

Introduction Perinatal outcomes are shaped by clinical, social, and environmental factors, yet Canada lacks a nationally representative pregnancy cohort capturing these influences at the individual-level. This gap has limited the ability to...

Development and validation of an online dynamic nomogram based on the atherogenic index of plasma to screen nonalcoholic fatty liver disease

Abstract Background Nonalcoholic fatty liver disease (NAFLD), a common liver disease worldwide, can be reversed early in life with lifestyle and medical interventions. This study aimed to develop a noninvasive tool to screen NAFLD accuratel...

The cartoon guide to statistics

Updated version featuring all new material. If you have ever looked for P-values by shopping at P mart, tried to watch the Bernoulli Trails on People's Court, or think that the standard deviation is a criminal offense in six states, then yo...

Supramolecular soft matter in traditional Chinese medicine: multiscale structure-function evidence, critical limitations, and translational challenges.

Oxidation‐etching induced morphology regulation of Cu catalysts for high‐performance electrochemical N2 reduction

Abstract Renewable‐electricity‐driven N2 reduction is an attractive approach for ambient NH3 synthesis, but active electrocatalysts are needed to enable the N2 reduction reaction. Monolithic electrodes with active components anchored on con...

Establishment of a Pre-vascularized 3D Lung Cancer Model in Fibrin Gel—Influence of Hypoxia and Cancer-Specific Therapeutics

Lung cancer is the most frequently diagnosed cancer worldwide and the one that causes the highest mortality. In order to understand the disease and to develop new treatments, in vitro human lung cancer model systems which imitate the physio...

Lipid peroxidation and DNA oxidation caused by dental filling materials

Background/purpose: The two direct dental restorative materials most commonly used today are silver-mercury amalgam and resin-based composites. The purpose of this study was to examine the effects of these two restorative materials and subs...

Mobile App Prototype in Older Adults for Postfracture Acute Pain Management: User-Centered Design Approach

BackgroundPostfracture acute pain is often inadequately managed in older adults. Mobile health (mHealth) technologies can offer opportunities for self-management of pain; however, insufficient apps exist for acute pain management after a fr...

From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases

The skeletal system is an important support structure in the human body, and its homeostatic state is highly relevant to the development of a wide range of orthopaedic diseases. The search for key regulatory factors associated with skeletal...

Quantum Computing

Quantum Computing for Healthcare: A Review

In recent years, the interdisciplinary field of quantum computing has rapidly developed and garnered substantial interest from both academia and industry due to its ability to process information in fundamentally different ways, leading to ...