Academic Articles & Research Papers

C3a Enhances the Formation of Intestinal Organoids through C3aR1

C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied....

Case report: Rapid development of amyloid A amyloidosis in temporal arteritis with SAA1.3 allele; An unusual case of intestinal amyloidosis secondary to temporal arteritis

Temporal arteritis (TA) is a large-vessel vasculitis mostly seen in older patients. Amyloid A (AA) amyloidosis secondary to a chronic inflammation induces multiple organ dysfunctions, including a dysfunction of the gastrointestinal tract. H...

Causal analysis between altered levels of interleukins and obstructive sleep apnea

BackgroundInflammation proteins including interleukins (ILs) have been reported to be related to obstructive sleep apnea (OSA). The aims of this study were to estimate the levels for several key interleukins in OSA and the causal effects be...

A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin

Abstract Background Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in the pathogen...

Single Eye mRNA-Seq Reveals Normalisation of the Retinal Microglial Transcriptome Following Acute Inflammation

Background: Whether retinal microglia can maintain or restore immune homeostasis during and after inflammation is unclear. We performed single-eye mRNA-sequencing on microglia at different timepoints following a single inflammatory stimulus...

Microenvironment‐adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm‐associated diabetic chronic wound healing cascade

Abstract The presence of bacterial biofilms and the occurrence of excessive inflammatory response greatly imped the healing process of chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues...

Effects of Lactobacillus crispatus-Containing Probiotics and Metformin on Insulin Resistance, Inflammation, and Gut Microbiome in Polycystic Ovary Syndrome: Protocol for an Open-Label Randomized Controlled Trial.

MoringaLeafNet: A multi-class leaf disease dataset for precision agriculture and deep learning researchMendeley Data

Moringa Oleifera, which has outstanding nutritional and health benefits, is prized around the world because its leaves are rich in essential vitamins, antioxidants, and minerals that support digestion, help the immune system, and fight infl...

HDAC3 inhibition alleviates neuroinflammation and white matter injury after subarachnoid hemorrhage through modulation of BDNF/TrkB/NF-κB signaling.

Umbilical cord blood mononuclear cells for inflammation-related diseases: a narrative review of immunomodulatory mechanisms, clinical evidence, and translational perspectives.

Mechanistic Insights Into How Acupuncture Modulates Host Immunity via the Gut Microbiota-Macrophage Axis.

Near-infrared photochromic miniprotein enables photoacoustic molecular imaging of acute inflammation and intracellular antigens.

Integrative multiomics analysis of platelet-related genes unveils molecular subtypes and prognostic signatures in acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) remains challenging due to molecular heterogeneity and limited prognostic models integrating tumor microenvironment dynamics. While thrombocytopenia correlates with poor outcomes, the roles of platelet-...

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease

Abstract Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpopulations of...

Development and web-based implementation of a machine learning model for predicting one-year adverse outcomes in acute ischaemic stroke

BackgroundThis study aimed to develop an interpretable and clinically applicable machine learning prediction model to assess the risk of adverse outcomes within one year following acute ischaemic stroke, and to establish a corresponding web...

Advanced lung cancer inflammation index predicts in-hospital mortality and refines risk stratification in patients with cirrhosis.

Identification and Validation of Hub Genes Associated With Periodontitis and Systemic Lupus Erythematosus.

The Combined Value of the Prognostic Nutritional Index and Pan-Immune-Inflammation Value in Predicting Neoadjuvant Chemotherapy and Survival in Locally Advanced Colon Cancer: A Retrospective Study.

Sex Differences in the Association Between the Systemic Immune-Inflammation Index and Coronary Lesion Severity in Acute Coronary Syndrome.

The Role of Mitochondrial Homeostasis in the Pathogenesis of Chronic Rhinosinusitis.