Academic Articles & Research Papers

Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease

Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal me...

Photoluminescent Nanomaterials for Medical Biotechnology

Creation of various photoluminescent nanomaterials has significantly expanded the arsenal of approaches used in modern biomedicine. Their unique photophysical properties can significantly improve the sensitivity and specificity of diagnosti...

Economic Considerations in Medical Biotechnology

The biotechnology revolution has coincided with another revolution in health care: the emergence of finance and economics as major issues in the use and success of new medical technologies. Health care finance has become a major social issu...

Ethical issues in medical biotechnology.

The extraordinary revolution in biotechnology has created new possibilities for curing disease and manipulating our genetic heritage. It is easy to see how biotechnology can be used for medicinal purposes. Knowledge of the genetic makeup of...

Nanomaterials for cascade promoted catalytic cancer therapy

Abstract Catalytic therapy utilizing special substances (e.g., hydrogen peroxide and glucose) in tumor sites has attracted wide interest to achieve tumor‐specific therapy or improve the efficacy of other treatments. Benefiting from the sele...

CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy

Abstract Cell division cycle 25 (CDC25) phosphatases serve as crucial regulators of cell cycle phase transitions and essential components of the checkpoint machinery involved in DNA damage response. Emerging evidence indicates the oncogenic...

NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury

Abstract Background Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes an...

Targeting ferroptosis to rescue osteogenic differentiation in BRONJ-affected jawbone mesenchymal stem cells: the role of miR-145-3p and exosome-mediated therapy

Abstract Background Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, therapy-refractory condition driven by ferroptotic disruption of jawbone-derived mesenchymal stem cells (MSCs) biology. We dissect this mechanism to va...

The Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis

Rupesh K Srivastava, Leena Sapra Immunoporosis Lab, Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, IndiaCorrespondence: Rupesh K Srivastava, Tel +91 11-26593548, Email rupesh_srivastava13@ya...

Green Microfluidic Method for Sustainable and High-Speed Analysis of Basic Amino Acids in Nutritional Supplements

Amino acids (AAs) have broad nutritional, therapeutic, and medical significance and thus are one of the most common active ingredients of nutritional supplements. Analytical strategies for determining AAs are high-priced and often limited t...

YAP1 reactivation in cardiomyocytes following ECM remodelling contributes to the development of contractile force and sarcomere maturation

Abstract Cardiac diseases are fueled by extracellular matrix (ECM) remodelling. Together with the altered ECM chemical composition, the mechanical turmoil associated with ECM maladaptive remodelling in the pathological heart drives the shut...

Synthesis of Lawsonia inermis-encased silver–copper bimetallic nanoparticles with antioxidant, antibacterial, and cytotoxic activity

Flexibility-powered Pickering emulsion enhances mucus permeability to alleviate ulcerative colitis

Abstract The physicochemical properties of oral drug delivery carriers significantly influence their interactions with the intestinal barrier, which, in turn, affect their in vivo fate and therapeutic efficacy. As a delivery system with a h...

Pharmaceutical and Medical Biotechnology

Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Abstract For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effec...

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

The devastating effects and incurable nature of hereditary and sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa urgently require the development of new therapeutic strategies. Add...

Comparative Phytochemical Analysis of the Aerial Parts of <i>Pelargonium radula</i> and <i>Geranium macrorrhizum</i> Cultivated in Bulgaria Using GC-MS and HPLC

Background: Geraniaceae species are widely used in traditional medicine. Pelargonium radula and Geranium macrorrhizum are aromatic medicinal plants traditionally used in Bulgaria for their antimicrobial, anti-inflammatory, and wound-healing...

Regulatory requirements for the registration of generic medicines and format of drug dossiers: procedures in Sri Lanka in comparison with selected regulatory authorities

Background The regulatory requirements for approval of generic medicines and the format of compiling drug dossiers vary among regulatory authorities. The variation is particularly wide between High-income countries (HIC) and lower and middl...

The Effectiveness of some Communicative Strategies for Developing Speaking Skills among ESRI post Graduate Students at University of Sadat City

Despite the unparalleled characteristics of speaking skill and its vital role in EFL learning process specifically for post graduate students, it does not receive the attention it deserves due to the lack of everyday communication. So the a...

Adaptive Cloud-Based Extended Reality: Modeling and Optimization

Extended Reality (XR) &#x2014; which includes Virtual Reality and Augmented Reality &#x2014; promises to bring the virtual and telepresence experience to another level. Unfortunately, solutions leveraging these technologies require special ...