Academic Articles & Research Papers

Circular Economy in Industrial Design Research: A Review

In the past decades, industrial design practice and research have focused extensively on how to optimize production and consumption, as a way to prevent negative environmental impacts, such as resource depletion, pollution, and excessive wa...

Health researchers' experience collaborating with patient partners: a qualitative study

Abstract Background Patient-oriented research (POR) and patient engagement (PE) have been increasingly adopted over recent decades, as they generate many positive academic and patient outcomes within various health research fields. While th...

Editorial: Mechanisms and Effectiveness of Complementary and Alternative Medicine for Pain Management

Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition

The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with the aim of identifying older adul...

Sex- and age-specific effects of fat distribution on bone mineral density

Background: BMI cannot distinguish fat distribution and may mask the true effects of different fat depots on bone mineral density (BMD). To investigate sex- and age-specific associations between fat distribution and BMD and its mediating ro...

Copper exposure association with prevalence of non-alcoholic fatty liver disease and insulin resistance among US adults (NHANES 2011–2014)

Background: Excessive copper (Cu) has risky effect on insulin resistance (IR), oxidative stress and inflammation. Instead, some studies reported serum Cu to be protective for non-alcoholic fatty liver disease (NAFLD). The aim of this study ...

Factors Associated with Quality of Life Among Older Adults with Chronic Disease in Taiwan

Background: There have been many studies reviewing quality of life (QoL) of older population and found an inverse association between QoL and chronic diseases. However, previous studies have focused only on that of people with specific dise...

Expert Consensus on Diagnosis and Management of Secondary Sarcopenia in Adults in Colombia: A Modified Delphi Study

ABSTRACT Background Secondary sarcopenia driven by chronic disease, acute illness, immobilization, malnutrition or treatment‐related factors contributes to functional decline, falls, disability, readmission and mortality. In Colombia, uneve...

Correlation between sarcopenia and changes in oligodendrocyte lineage cells in the brains of Alzheimer's disease model mice

Background: Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by cognitive dysfunction. The discovery and identification of non-cognitive symptoms in the preclinical stage hold promise for early diagnosis and ...

Long Noncoding RNAs in Neurodegenerative Diseases: Pathogenesis and Potential Implications as Clinical Biomarkers

Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are progressive and ultimately fatal. NDD onset is influenced by several fa...

Rare genetic diseases associated with G-quadruplex-induced replication stress

Abstract DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substant...

Linking Spiritual and Religious Coping With the Quality of Life of Community-Dwelling Older Adults and Nursing Home Residents

Objective: This study examined the effect of Positive and Negative Spiritual and Religious Coping (SRC) upon older Brazilian’s quality of life (QOL). Method: A secondary analysis of data collected from 77 nursing home residents (NHRs; M age...

Impact of age-friendly living environment and intrinsic capacity on functional ability in older adults: a cross-sectional study

Abstract Background The World Health Organization (WHO) has proposed healthy aging framework, supposing that intrinsic capacity (IC), environment and their interaction may have influence on functional ability (FA). It was still unclear how ...

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the un...

The interplay of risk factors for future falls and fall-related injuries among community-dwelling older adults: a Bayesian network analysis

Abstract Background Falls are a leading global cause of injury and mortality in older adults, necessitating understanding risk factor interplay for prevention. This study aims to investigate complex interactions among risk factors associate...

Heterogeneity in Trajectories of Body Mass Index and Their Associations with Mortality in Old Age: A Literature Review

This article reviewed studies to investigate the association between trajectories of body mass index (BMI) and mortality among older adults. Investigators conducted a systematic search of published peer-reviewed literature in the PubMed dat...

Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease

Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vul...

Association between Postoperative Neck Pain and Intraoperative Transcranial Motor-Evoked Potential Waveforms of the Trapezius Muscles in Patients with Cervical Myelopathy Who Underwent Cervical Laminoplasty

Study Design Retrospective study. Purpose Cervical laminoplasty is safe and effective for treating cervical myelopathy but has a higher frequency of postoperative axial pain compared to other methods. Several studies have reported on the ca...

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with vitamin E metabolism marked by urinary α-tocopheronolactone hydroquinone (α-TLH...

Measles IgG Antibodies: Is There a Protective Role in COVID 19 Pandemic?‎ ‎

Background and study aim: Epidemiological   data reported lower death rates of COVID-19 cases   in countries with   higher & ‎recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer ‎in COVID-1...