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Computable phenotype for real-world, data-driven retrospective identification of relapse in ANCA-associated vasculitis

Vladimir Tesar, Conor Judge, John Kelleher, Zdenka Hrušková et al. • RMD Open (2024)

Objective ANCA-associated vasculitis (AAV) is a relapsing-remitting disease, resulting in incremental tissue injury. The gold-standard relapse definition (Birmingham Vasculitis Activity Score, BVAS>0) is often missing or inaccurate in re...

DOAJ Open Access (DOAJ) DOI: 10.1136/rmdopen-2023-003962

Design and Optimization of Trastuzumab-Functionalized Nanolipid Carriers for Targeted Capecitabine Delivery: Anti-Cancer Effectiveness Evaluation in MCF-7 and SKBR3 Cells

Das S, Satapathy BS, Pattnaik G, Pattanaik S et al. • International Journal of Nanomedicine (2025)

Shubhashree Das,1 Bhabani Sankar Satapathy,2 Gurudutta Pattnaik,1 Sovan Pattanaik,3 Yahya Alhamhoom,4 Mohamed Rahamathulla,4 Mohammed Muqtader Ahmed,5 Ismail Pasha6 1Department of Pharmaceutics, School of Pharmacy and Life Sciences, Centuri...

DOAJ Open Access (DOAJ)

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin et al. • Nature Communications (2024)

Abstract Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-024-47424-z

Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers

Cayetano Javier Carrión-García, Eduardo Jesús Guerra-Hernández, Belén García-Villanova, Mauro Serafini et al. • Antioxidants (2020)

(1) Background: Little is known about the interlinkages between dietary and plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body’s antioxidant and inflammation response. Our aim was to explore these assoc...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox9040301

Operating pesticide use reduction within the boundary of food security in peri-urban settings

Yuquan W. Zhang, Bruce A. McCarl, Zhengwei Cao, Qiang Li et al. • Fundamental Research (2022)

Pesticide use in peri-urban areas affects the urban environment and public health, and reducing the use may present food security issues for urban dwellers. In this study, we explore how a municipality-adopted goal of a 20% reduction in pes...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.fmre.2022.04.003

Mangifera Indica leaf extracts promote hair growth via activation of Wnt signaling pathway in human dermal papilla cells

Haesoo Jung, Da-Min Jung, Sang-Soo Lee, Eun-Mi Kim et al. • Animal Cells and Systems (2022)

The crosstalk between androgens and Wnt signaling pathways is critical in the hair growth cycle. Therefore, natural products that target these two pathways for the inhibition of hair loss are sought after. In this study, we investigated the...

DOAJ Open Access (DOAJ) DOI: 10.1080/19768354.2022.2085790

Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila

Cagri Yalgin, Bohdana Rovenko, Ana Andjelković, Margot Neefjes et al. • iScience (2020)

Summary: Dopaminergic (DA) neurons have been implicated as key targets in neurological disorders, notably those involving locomotor impairment, and are considered to be highly vulnerable to mitochondrial dysfunction, a common feature of suc...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.isci.2020.101362

Serum amyloid beta 42 levels correlated with metabolic syndrome and its components

Kecheng Li, Kecheng Li, Xiaoli Zhou, Xiaoli Zhou et al. • Frontiers in Endocrinology (2024)

IntroductionBeta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer’s disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-β pe...

DOAJ Open Access (DOAJ) DOI: 10.3389/fendo.2024.1278477

Conserved lipid-facing basic residues promote the insertion of the porin OmpC into the E. coli outer membrane

Janine H. Peterson, Lixinhao Yang, James C. Gumbart, Harris D. Bernstein • mBio (2025)

ABSTRACT Almost all integral membrane proteins that reside in the outer membrane (OM) of gram-negative bacteria contain a closed amphipathic β sheet (“β barrel”) that serves as a membrane anchor. The membrane integration of β barrel structu...

DOAJ Open Access (DOAJ) DOI: 10.1128/mbio.03319-24

Male Infertility and Its Correlates in Chuadanga District of Bangladesh

Sazin Islam, Md. Shariful Islam, Sharmin Akter, A. M. Mujahidul Islam et al. • American Journal of Men's Health (2025)

Male infertility is an escalating global health concern, yet it remains under-researched in Bangladesh. The factors contributing to this issue have not been thoroughly studied. This study aims to identify the factors associated with male in...

DOAJ Open Access (DOAJ) DOI: 10.1177/15579883251372452

HEALTH TECHNOLOGY ASSESSMENT EVIDENCE ON E-HEALTH/M-HEALTH TECHNOLOGIES: EVALUATING THE TRANSPARENCY AND THOROUGHNESS

Vladimir Vuković, Carlo Favaretti, Walter Ricciardi, Chiara de Waure • International Journal of Technology Assessment in Health Care (2018)

OBJECTIVES: Evaluation is crucial for integration of e-Health/m-Health into healthcare systems and health technology assessment (HTA) could offer sound methodological basis for these evaluations. Aim of this study was to look for HTA report...

OPENALEX DOI: https://doi.org/10.1017/s0266462317004512

Time dynamics of symptom progression in patients with acute pancreatitis: a Dynamic Time Warping analysis

Rui Han, Xiaoyu Deng, Hebing Liu, Yujie Duan et al. • Frontiers in Medicine (2025)

BackgroundAcute pancreatitis (AP) morbidity has been increasing in recent years. Patients with AP exhibit highly variable symptom patterns over time, posting challenges to traditional analytical methods. Dynamic Time Warping (DTW) effective...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2025.1703268

Depressive phenotype shapes behavioral, neuroendocrine and molecular responses to repetitive transcranial magnetic stimulation in preclinical models of depression

Marta Boffa, Marta Boffa, Sara Spalletti, Sara Spalletti et al. • Frontiers in Molecular Neuroscience (2026)

IntroductionRepetitive transcranial magnetic stimulation (rTMS) is an established non-invasive treatment for treatment-resistant depression (TRD), yet its neurobiological mechanisms remain only partially understood. We investigated whether ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2026.1939025

Impact of Competitiveness on Economic Growth: Case Study of WEF Countries

Mohsen Mohammadi Khyareh, Nasrin Rostami • Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī (2020)

Many scholars emphasize the importance of economic competitiveness in the improvement of economic growth. However, studies that quantitatively analyze the interconnection between different components of competitiveness in one economy and th...

DOAJ Open Access (DOAJ) DOI: 10.22054/joer.2020.11903

Cost-Effectiveness Analysis of Pan-Genotypic Sofosbuvir-Based Regimens for Treatment of Chronic Hepatitis C Genotype 1 Infection in China

Hui Jun Zhou, Jing Cao, Hui Shi, Nasheen Naidoo et al. • Frontiers in Public Health (2021)

Background: Hepatitis C virus (HCV) genotype 1 is the most prevalent HCV infection in China. Sofosbuvir-based direct antiviral agent (DAA) regimens are the current mainstays of treatment. Sofosbuvir/velpatasvir (SOF/VEL) and sofosbuvir/ledi...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpubh.2021.779215

Persuasive health technology

Lisette (J.E.W.C.) van Gemert-Pijnen, Saskia M. Kelders, Nienke Beerlage-de Jong, Harri Oinas-kukkonen A B • Routledge eBooks (2018)

This chapter aims to describe persuasive health technology to help you understand the strategies that can improve the adherence to eHealth technologies and increase their effectiveness. We will show that technology can do more than only be ...

OPENALEX Open Access DOI: https://doi.org/10.4324/9781315385907-11

Development of an evaluation framework for health information communication technology in contemporary pharmacy practice

Ayomide Ogundipe, Tin Fei Sim, Lynne Emmerton • Exploratory Research in Clinical and Social Pharmacy (2023)

Background: Health information communication technology (ICT) has rapidly evolved in contemporary pharmacy practice worldwide. The Australian healthcare system is experiencing a paradigm shift to real-time interconnectivity for practitioner...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rcsop.2023.100252

Ethical perspectives on health technology assessment

Henk ten Have • International Journal of Technology Assessment in Health Care (2004)

This study analyses why ethical aspects play a minor role in health technology assessment (HTA) studies, even when comprehensive approaches of technology assessment are advocated. Technology is often regarded as a value-neutral tool. At the...

OPENALEX DOI: https://doi.org/10.1017/s0266462304000819