Reset
Showing 20 of 2,024 academic articles

Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

M. Camila Melo-Narvaez, Fee Gölitz, Eshita Jain, Janine Gote-Schniering et al. • Respiratory Research (2025)

Abstract Background Human precision-cut lung slices (hPCLS) are a unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research. However, tissue availability, generation, and cultivation time r...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12931-025-03132-w

Period of Arrhythmia Anchored around an Infarction Scar in an Anatomical Model of the Human Ventricles

Daria Mangileva, Pavel Konovalov, Arsenii Dokuchaev, Olga Solovyova et al. • Mathematics (2021)

Rotating nonlinear waves of excitation in the heart cause dangerous cardiac arrhythmias. Frequently, ventricular arrhythmias occur as a result of myocardial infarction and are associated with rotation of the waves around a post-infarction s...

DOAJ Open Access (DOAJ) DOI: 10.3390/math9222911

Wild immunology

Amy B. Pedersen, Simon A. Babayan • Molecular Ecology (2011)

In wild populations, individuals are regularly exposed to a wide range of pathogens. In this context, organisms must elicit and regulate effective immune responses to protect their health while avoiding immunopathology. However, most of our...

OPENALEX DOI: https://doi.org/10.1111/j.1365-294x.2010.04938.x

Immunology of Psoriasis

Michelle Anne Lowes, Mayte Suárez‐Fariñas, James G. Krueger • Annual Review of Immunology (2014)

The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-associated lymphoid tissue (SALT). The reaction of these components to injury allows an effective cutaneo...

OPENALEX Open Access DOI: https://doi.org/10.1146/annurev-immunol-032713-120225 PMC: 4229247

DNA methylation patterns of circadian and ultradian genes are altered in the peripheral blood of patients with hidradenitis suppurativa

Uppala Radhakrishna, Uppala Ratnamala, Devendrasinh D. Jhala, Lavanya V. Uppala et al. • Frontiers in Immunology (2024)

BackgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and buttocks. The pathogenesis of HS is not fully understood, bu...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2024.1475424

The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2 [v1; ref status: indexed, http://f1000r.es/201]

Benjamin K Dickerman, Jocelyn A McDonald, Ganes C Sen • F1000Research (2013)

The primary function of the dsRNA binding protein (dsRBP) PACT/RAX is to activate the dsRNA dependent protein kinase PKR in response to stress signals.  Additionally, it has been identified as a component of the small RNA processing pathway...

DOAJ Open Access (DOAJ) DOI: 10.12688/f1000research.2-220.v1

Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8+ T cells towards the center of human lung tumors

Demi Brownlie, Andreas von Kries, Giampiero Valenzano, Nicole Wild et al. • OncoImmunology (2023)

Lung cancer is a leading cause of cancer-related death worldwide. Despite recent advances in tissue immunology, little is known about the spatial distribution of tissue-resident lymphocyte subsets in lung tumors. Using high-parameter flow c...

DOAJ Open Access (DOAJ) DOI: 10.1080/2162402X.2023.2233402

Current Protocols in Immunology

• Current Protocols in Immunology (2018)

Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional acti...

OPENALEX DOI: https://doi.org/10.1002/(issn)1934-368x

Characterization of Primate Antibody Responses to Administered Murine Monoclonal Immunoglobulin

D.E. Milenic, B. Detrick, J.C. Reynolds, D. Colcher • The International Journal of Biological Markers (1990)

Murine monoclonal antibodies (MAb) are currently being assessed for their utility as tools in cancer management. Anti-murine immunoglobulin responses have been observed in many patients receiving monoclonal antibody treatment. In this study...

DOAJ Open Access (DOAJ) DOI: 10.1177/172460089000500403

Free Amino Acids in Human Milk: A Potential Role for Glutamine and Glutamate in the Protection Against Neonatal Allergies and Infections

Joris H. J. van Sadelhoff, Selma P. Wiertsema, Johan Garssen, Johan Garssen et al. • Frontiers in Immunology (2020)

Breastfeeding is indicated to support neonatal immune development and to protect against neonatal infections and allergies. Human milk composition is widely studied in relation to these unique abilities, which has led to the identification ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2020.01007

Cancer Immunology

Olivera J. Finn • New England Journal of Medicine (2008)

This review is a comprehensive account of the current status of tumor immunology, beginning with the identification of human tumor antigens and ending with a summary of clinical applications of what we know about the immunology of tumors....

OPENALEX DOI: https://doi.org/10.1056/nejmra072739

Basic Immunology

John R. Crowther • Humana Press eBooks (2003)

A knowledge of immunology is essential in developing ELISAs. Information about the specific system and similar systems already studied from the biochemical and immunological aspects is important to allow development of assays and to determi...

OPENALEX DOI: https://doi.org/10.1385/0-89603-279-5:1

Poly (acrylic acid)/tricalcium phosphate nanoparticles scaffold enriched with exosomes for cell-free therapy in bone tissue engineering: An in vivo evaluation

Nahid Moradi, Mina Soufi-Zomorrod, Simzar Hosseinzadeh, Masoud Soleimani • BioImpacts (2024)

Introduction: This study aimed to assess the potential of poly (acrylic acid)/tricalcium phosphate nanoparticles (PAA/triCaPNPs) scaffold in terms of biocompatibility and osteoconductivity properties the in-vivo evaluation as well as to inv...

DOAJ Open Access (DOAJ) DOI: 10.34172/bi.2023.27510

Seroprevalence of dengue, yellow fever, and related flaviviruses among the rural human population in Nguruman and Kerio Valley, Kenya

Mercy Hokah Kibathi, Mercy Hokah Kibathi, Edith Chepkorir, Sepha Nyatichi Mabeya et al. • Frontiers in Virology (2024)

BackgroundYellow fever virus (YFV) and dengue virus (DENV) are among the major re-emerging arboviruses that pose a significant threat to public health. Their associated burden and prevalence can be substantially underestimated due to insuff...

DOAJ Open Access (DOAJ) DOI: 10.3389/fviro.2024.1459021

Topical Pharmacological Treatment of Actinic Keratoses: Focus on Tirbanibulin 1% Ointment

Mario Valenti, Matteo Bianco, Alessandra Narcisi, Antonio Costanzo et al. • Dermatology Practical & Conceptual (2024)

Actinic keratosis (AK) is a frequent precancerous skin lesion that mostly affects chronically sun-exposed areas. Chronic sun damage leads to various mutations in onco-suppressor and oncogenic genes which cause an uncontrolled proliferation ...

DOAJ Open Access (DOAJ) DOI: 10.5826/dpc.1403S1a145S

Joint effects of ethnic enclave residence and ambient volatile organic compounds exposure on risk of gestational diabetes mellitus among Asian/Pacific Islander women in the United States

Andrew D. Williams, Sandie Ha, Edmond Shenassa, Lynne C. Messer et al. • Environmental Health (2021)

Abstract Background Asian/Pacific Islander (API) communities in the United States often reside in metropolitan areas with distinct social and environmental attributes. Residence in an ethnic enclave, a socially distinct area, is associated ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12940-021-00738-7

Diversity of Rickettsia species in collected ticks from Southeast Iran

Ali Qorbani, Mohammad Khalili, Saeidreza Nourollahifard, Ehsan Mostafavi et al. • BMC Veterinary Research (2024)

Abstract Rickettsia occurs worldwide and rickettsiosis is recognized as an emerging infection in several parts of the world. Ticks are reservoir hosts for pathogenic Rickettsia species in humans and domestic animals. Most pathogenic Rickett...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12917-024-04142-4