Academic Articles & Research Papers

Effect of Adherence to the Mediterranean Diet on Maternal Iron Related Biochemical Parameters during Pregnancy and Gestational Weight Gain

Gestation is a crucial life stage for both women and offspring, and outcomes are affected by many environmental factors, including diet. The Mediterranean dietary pattern (MD) is considered a healthy eating pattern that can provide the nutr...

Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study [version 3; peer review: 2 approved, 1 approved with reservations]

Background High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to decide, where appropriate, which evidence-based medicines best fit the person’s life, belie...

Prevalence of gastric varices in cirrhotic patients presenting with upper GI bleed at Shifa International hospital: an insidious threat

Abstract Introduction Liver cirrhosis (LC) is a serious condition occurring as a result of chronic liver disease. Amongst its various complications, acute variceal bleeding is the most feared, which presents as esophageal, gastroesophageal,...

Plasma Exchange for ANCA-Associated Vasculitis: An International Survey of Patient PreferencesPlain Language Summary

Rationale & Objective: We sought to elicit patient preferences regarding the use of plasma exchange in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and its tradeoffs of risk of kidney failure and risk of serious infec...

Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity

Objective To explore factors that potentially impact external validation performance while developing and validating a prognostic model for hospital admissions (HAs) in complex older general practice patients.Study design and setting Using ...

Survival Impact of Nephroureterectomy for De Novo Stage IV Nonmetastatic and Metastatic Upper Tract Urothelial Carcinoma

BackgroundWhether nephroureterectomy (NU) provides survival benefits in patients with stage IV upper tract urothelial carcinoma (UTUC) remains unclear. We compared the effect of chemotherapy (CT) alone with that of CT combined with NU (CT +...

Epidemiology of Drowning Incidents among Children at Sultan Qaboos University Hospital Oman

Objectives: We sought to study the epidemiology of drowning among children reported at Sultan Qaboos University Hospital in Oman. Methods: We conducted a retrospective study of the patients who presented to the emergency department with a h...

Epigenetic Mechanisms and Nephrotic Syndrome: A Systematic Review

A small subset of people with nephrotic syndrome (NS) have genetically driven disease. However, the disease mechanisms for the remaining majority are unknown. Epigenetic marks are reversible but stable regulators of gene expression with uti...

Epidemiology: Beyond the Basics

Epidemiology: Beyond the BasicsAuthors: SZKLO, Moyses, MD, DrPH (Johns Hopkins Univ.); NIETO, F. Javier, MD, PhD (Johns Hopkins Univ.) Bibliographic Data: (ISBN: 0–8342-0618–8, Aspen Publishers, Inc., 2000, $55.00) 495 pages, soft cover Aud...

Epidemiology, Biostatistics and Preventive Medicine

Canadian Patterns of Antimicrobial Resistance: Overview of Current Trends Related to Hospital Pathogens

Selection of appropriate empirical antibiotic therapy is dependent on many factors, not the least of which is an understanding of antimicrobial resistance rates in the patient population that is undergoing treatment. Resistance rates may va...

Tissue Sodium in Patients With Early Stage Hypertension: A Randomized Controlled Trial

Background Sodium (Na+) stored in skin and muscle tissue is associated with essential hypertension. Sodium magnetic resonance imaging is a validated method of quantifying tissue stores of Na+. In this study, we evaluated tissue Na+ in patie...

EFFICACY AND SAFETY OF INCLISIRAN BY BASELINE BODY MASS INDEX: A POST HOC POOLED ANALYSIS OF THE ORION-9, ORION-10 AND ORION-11 PHASE III RANDOMIZED CONTROLLED TRIALS

Therapeutic Area: ASCVD/CVD Risk Factors Background: Excessive bodyweight, often associated with dyslipidemia, may affect the pharmacology of drugs. Inclisiran, a small interfering RNA targeting PCSK9 hepatic mRNA, is an effective LDL-C low...

Engaging Older Adults to Guide the Development of Passive Home Health Monitoring to Support Aging in Place

By 2050, most adults aged 65 and older in the United States will want to age independently at home, a goal that will strain healthcare resources. Adults aged 50 and older (N = 112) were recruited for study participation between 2018 and 202...

Knowledge, attitude, and practices of pediatricians about children’s oral health

BACKGROUND: Many pediatric oral diseases are preventable if physicians recognize and encourage preventive care and refer patients to dentists whenever necessary. Parents usually visit pediatricians for routine care during the first few year...

Clustered Regularly Interspaced Short Palindromic Repeat/Cas12a Mediated Multiplexable and Portable Detection Platform for GII Genotype Porcine Epidemic Diarrhoea Virus Rapid Diagnosis

Porcine epidemic diarrhoea virus (PEDV) is a member of the genus Alphacoronavirus in the family Coronaviridae. It causes acute watery diarrhoea and vomiting in piglets with high a mortality rate. Currently, the GII genotype, PEDV, possesses...

Association of self-reported dental caries with sex, lifestyle, and problematic Internet use among elementary school children in Japan

Abstract Background Dental caries is the most prevalent disease in elementary schoolchildren in Japan. Problematic Internet use (PIU) has increased among children; however, its association with caries has rarely been studied. We aimed to ex...

Hyperuricemia and dementia – a case-control study

Abstract Background There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric acid (SUA) lev...

Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study

Aim: to determine the role of serum lactate and diabetic ketoacidosis (DKA) severity as predictors for five-days mortality in DKA patients. Methods: a prospective cohort study was conducted in DKA patients admitted to emergency department (...

Mapping the Burden of Fungal Diseases in the United Arab Emirates

The United Arab Emirates has very little data on the incidence or prevalence of fungal diseases. Using total and underlying disease risk populations and likely affected proportions, we have modelled the burden of fungal disease for the firs...