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Proteomic analysis of synergetic neuroprotective effect of adenosine, thiamine, niacin and cyanocobalamin in pathophysiology of diabetic polyneuropathy

O. A. Gromova, I. Yu. Torshin, A. G. Moiseenok • Фармакоэкономика (2025)

Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect ...

DOAJ Open Access (DOAJ) DOI: 10.17749/2070-4909/farmakoekonomika.2024.285

Cranial ultrasonographic findings in newborns exposed to SARS-CoV-2: a single-centre cross-sectional analysis

Bruna Scalia, Marco Andrea Nicola Saporito, Laura Mauceri, Alessandro Valerio Saporito et al. • Italian Journal of Pediatrics (2024)

Abstract Background SARS-CoV-2’s potential consequences on the developing brain are still unknown. The aim of this study was to describe cranial ultrasonographic (cUS) findings in a population of newborns exposed to SARS-CoV-2 born at San M...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13052-024-01826-3

Effects of Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes

Shih-Ho Wang, Chin-Hu Wu, Chin-Chuan Tsai, Tai-Yu Chen et al. • Current Issues in Molecular Biology (2022)

Taraxacum officinale (dandelion) is often used in traditional Chinese medicine for the treatment of cancer; however, the downstream regulatory genes and signaling pathways mediating its effects on breast cancer remain unclear. The present s...

DOAJ Open Access (DOAJ) DOI: 10.3390/cimb44050142

miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4

Jinyu Liu, Xiaowei Yuan, Wei Chen, Dongqin Shen • Clinical and Applied Thrombosis/Hemostasis (2026)

Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis dia...

DOAJ Open Access (DOAJ) DOI: 10.1177/10760296261468449

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory

Suhel Tamboli, Sanjay Singh, Dimitry Topolnik, Mohamed El Amine Barkat et al. • Cell Reports (2024)

Summary: In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, the specific behavioral conditions that lead to circuit disinhibition remai...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.celrep.2024.114115

Computational analyses on delineating specificity of 2-hydroxy-3,5-dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins

Dakshinamurthy Sivakumar, Natarajan Hari, Thirunavukkarasu Sivaraman • Bangladesh Journal of Pharmacology (2014)

We have herein computationally examined binding affinities and specificity of 2-hydroxy-3,5-dinitrobenzamide (HDNB), a small chemical molecular BH3-mimetic identified by means of ‘peptidodynmimetic method’, on the BH3-binding grooves of six...

DOAJ Open Access (DOAJ)

Spray dried inulin–sodium carboxymethylcellulose microcarriers with solid-to-colloidal transition: Development for foliar delivery of polyphenol-rich extract

Rita Patrizia Aquino, Teresa Mencherini, Pierluigi Mazzei, Tiziana Esposito et al. • Carbohydrate Polymer Technologies and Applications (2025)

This study reports on the development of a carbohydrate-based spray-dried microparticulate system (F-CHES) conceived for the stabilization and foliar delivery of polyphenol-rich plant extracts for sustainable phyto defense applications. Che...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.carpta.2025.101023

Investigating the performance of the fluorescent sensor g-C3N4/Fe/Cu in detecting the Tenofovir drug

Nafiseh Hajian Afarani, Fatemeh Keshavarzi, Kahin Shahanipour, Seyed Amir Zarei • Scientific Reports (2025)

Abstract Tenofovir is an antiviral drug that prevents the replication of AIDS and hepatitis B viruses. To minimize the harmful side effects of the drug on the body, it is essential to determine its precise concentration in the blood. Fluore...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-08877-4

Sequential Portal Vein Embolization and Percutaneous Radiofrequency Ablation for Future Liver Remnant Growth: A Minimally Invasive Alternative to ALPPS Stage-1 in Treatment of Hepatocellular Carcinoma

Qiang Wang, Qiang Wang, Yujun Ji, Torkel B. Brismar et al. • Frontiers in Surgery (2021)

Background: To evaluate the feasibility and efficacy of sequential portal vein embolization (PVE) and radiofrequency ablation (RFA) (PVE+RFA) as a minimally invasive variant for associating liver partition and portal vein ligation for stage...

DOAJ Open Access (DOAJ) DOI: 10.3389/fsurg.2021.741352

Cerebrospinal fluid-stem cell interactions may pave the path for cell-based therapy in neurological diseases

Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang et al. • Stem Cell Research & Therapy (2018)

Abstract Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and other neurological disea...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-018-0807-3

Sex-based estimation of biological variation in plasma-free amino acid concentrations among healthy adults

Müjgan Ercan, Emiş Deniz Akbulut, Ayşen Caniklioğlu, Esra Fırat Oğuz et al. • Journal of Mass Spectrometry and Advances in the Clinical Lab (2025)

Introduction: Free amino acid (FAA) analysis plays a crucial role in diagnosing and monitoring inborn errors of metabolism, assessing nutritional status, and identifying metabolic imbalances associated with various diseases. This study aime...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmsacl.2025.04.010

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

Temesgen GB, Menon M, Gizaw ST, Yimenu BW et al. • International Journal of General Medicine (2022)

Gelagey Baye Temesgen,1 Menakath Menon,2 Solomon Tebeje Gizaw,2 Bayu Wondimneh Yimenu,1 Melaku Mekonen Agidew3 1Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Medical Biochemistry School o...

DOAJ Open Access (DOAJ)

Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline

Mahdie Kian, Elham Hosseini, Tooba Abdizadeh, Taimour Langaee et al. • EXCLI Journal : Experimental and Clinical Sciences (2022)

Polycystic ovary syndrome (PCOS) is the most common cause of women’s infertility. Some inflammatory pathways play a pivotal role in the pathogenesis of PCOS. This study aimed to investigate the possible beneficial effects of minocycline on ...

DOAJ Open Access (DOAJ) DOI: 10.17179/excli2021-4534

Impact of Myocardial Ischemia and Revascularization by Percutaneous Coronary Intervention on Circulating Level of Soluble ST2

Alkhateeb A, Mahmoud HEM, AK M, Hassan MH et al. • Vascular Health and Risk Management (2023)

Areej Alkhateeb,1 Hossam Eldin M Mahmoud,1 Mohammed AK,1 Mohammed H Hassan,2 Abdel Rahim Mahmoud Muddathir,3 Ahmed G Bakry1 1Cardiology Division of Internal Medicine Department, South Valley University Hospital, Faculty of Medicine, South V...

DOAJ Open Access (DOAJ)

Synthesis of 9-arylalkynyl- and 9-aryl-substituted benzo[b]quinolizinium derivatives by Palladium-mediated cross-coupling reactions

Siva Sankar Murthy Bandaru, Darinka Dzubiel, Heiko Ihmels, Mohebodin Karbasiyoun et al. • Beilstein Journal of Organic Chemistry (2018)

9-Arylbenzo[b]quinolizinium derivatives were prepared with base-free Suzuki–Miyaura coupling reactions between benzo[b]quinolizinium-9-trifluoroborate and selected benzenediazonium salts. In addition, the Sonogashira coupling reaction betwe...

DOAJ Open Access (DOAJ) DOI: 10.3762/bjoc.14.161

Synthesis and properties of fluorene based small molecule acceptors containing aromatic malononitrile functionalities

Sarah E. Brock, Dariia Yehorova, Brycelyn M. Boardman • Results in Chemistry (2022)

Four novel small molecule acceptors (SMA) with fluorene-based cores were synthesized with terminal phenyl, thienyl, and furyl malononitrile groups in good yields. The products were obtained from a two-step reaction of 2,2′-(9,9-dioctyl-9H-f...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rechem.2022.100320

Water and soil pollution as determinant of water and food quality/contamination and its impact on female fertility

Justin Rashtian, Diana E. Chavkin, Zaher Merhi • Reproductive Biology and Endocrinology (2019)

Abstract A mounting body of the literature suggests that environmental chemicals found in food and water could affect female reproduction. Many worldwide daily-used products have been shown to contain chemicals that could incur adverse repr...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12958-018-0448-5

Review on: Women with Polycystic Ovary Syndrome

Neelam Gusain, Ashish P. Anjankar, Ranjit S. Ambad, Roshan K. Jha et al. • Journal of Pharmacy and Bioallied Sciences (2025)

One of the biggest health issues facing women in their childbearing years worldwide is polycystic ovarian syndrome, or PCOS. PCOS is a prevalent endocrine condition with well-known negative effects on metabolism, reproduction, and cardiovas...

DOAJ Open Access (DOAJ) DOI: 10.4103/jpbs.jpbs_1995_24