Reset
Showing 20 of 4,465 academic articles

In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity

Andre Luis Dias Araujo Mazzari, Mariella Guimarães Lacerda, Flora Aparecida Milton, Flora Aparecida Milton et al. • Frontiers in Pharmacology (2022)

Many medicinal plants species from European -such as Artemisia absinthium, Equisetum arvense, Lamium album, Malva sylvestris, Morus nigra, Passiflora incarnata, Frangula purshiana, and Salix alba- as well as Latin American traditions -such ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2022.826395

Efficacy, safety, and quality of life 4 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A in the phase 3 GENEr8-1 trial

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja, Emily Symington et al. • Research and Practice in Thrombosis and Haemostasis (2024)

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection. Objectives: Determine valoctocogene roxaparvovec du...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rpth.2024.102615

The Association of Parent-Child Communication With Internet Addiction in Left-Behind Children in China: A Cross-Sectional Study

Jingjing Cai, Yun Wang, Feng Wang, Jingjing Lu et al. • International Journal of Public Health (2021)

Objective: Internet addiction has emerged as a growing concern worldwide. This study aimed to compare the prevalence of Internet addiction between left-behind children (LBC) and non-left-behind children (non-LBC), and explore the role of pa...

DOAJ Open Access (DOAJ) DOI: 10.3389/ijph.2021.630700

Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases

Li Tao, Xiaomeng Ren, Wenhui Zhai, Zheng Chen • Molecules (2022)

Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physiological and pathological processes, including liver homeostasis and diseases. Recent studies demonstrate that non-canonical NF-κB signaling pathway plays an...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules27134275

Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress

Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda et al. • Frontiers in Pharmacology (2023)

Tendinopathy, a degenerative disease, is characterized by pain, loss of tendon strength, or rupture. Previous studies have identified multiple risk factors for tendinopathy, including aging and fluoroquinolone use; however, its therapeutic ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2023.1137952

Lactobacillus brevis 23017 Relieves Mercury Toxicity in the Colon by Modulation of Oxidative Stress and Inflammation Through the Interplay of MAPK and NF-κB Signaling Cascades

Xinpeng Jiang, Shanshan Gu, Di Liu, Lili Zhao et al. • Frontiers in Microbiology (2018)

Aims:Lactobacillus strains have protective effects against heavy metals while relieving oxidative stress and modulating the immune response. Mechanisms that ameliorate heavy metal toxicity and the relationship between probiotics and gut bar...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.02425

Fumaric acid regulates morphine tolerance in bone cancer pain through spinal MrgC receptor modulation

Sijie Liu, Minghao Tang, Jing Zhao, Lulu Zhang et al. • Pakistan Journal of Pharmaceutical Sciences (2026)

Background: Bone cancer pain (BCP) represents a debilitating complication that profoundly impacts patient quality of life and predisposes to psychological comorbidities, including depression and anxiety. Objectives: To investigate the effec...

DOAJ Open Access (DOAJ) DOI: 10.36721/PJPS.2026.39.8.233.1

Comparison of Vitamin B1 (Thiamin hydrochloride) Level in Brown Rice (Oryza nivara S.D.Sharma & Shastry) and Cooked Brown Rice by Alkalimetry Methods

Emerita Dyah Ayu Purwita Sari, Hendra Budiman, Anita Agustina Styawan, Choiril Hana Mustofa • Journal of Food and Pharmaceutical Sciences (2025)

Brown rice (Oryza nivara S.D.Sharma & Shastry) is a rice variety that belongs to the Graminae family. Brown rice contains vitamins A, B, C, Zn and B complex. Vitamin B1 is one type of vitamin that is not stable. Its stability is influenced ...

DOAJ Open Access (DOAJ) DOI: 10.22146/jfps.17037

Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells and in vivo zebrafish embryos

Teerapat Rodboon, Sasithorn Sirilun, Seiji Okada, Ryusho Kariya et al. • Research in Pharmaceutical Sciences (2020)

Background and purpose: Excessive melanin production caused by overactive tyrosinase (TYR) enzyme results in several dermatological problems. The TYR inhibitor, derived from metabolite changes during fermentation, has been well recognized f...

DOAJ Open Access (DOAJ) DOI: 10.4103/1735-5362.297852

Characterization of low-nitrogen quantum diamond for pulsed magnetometry applications

Jiashen Tang, Jiashen Tang, Connor A. Roncaioli, Andrew M. Edmonds et al. • Frontiers in Quantum Science and Technology (2025)

Ensembles of nitrogen-vacancy (NV) centers in diamond are versatile quantum sensors with broad applications in the physical and life sciences. The concentration of neutral substitutional nitrogen ([Ns0]) strongly influences NV electronic sp...

DOAJ Open Access (DOAJ) DOI: 10.3389/frqst.2025.1701548

Impact of prolonged obstructive sleep apnea syndrome disease course on retinal-choroidal microcirculation: a WF-SS-OCTA study

Chaomin Chen, Xinyi Chen, Lixia Qin, Mingming Zhao et al. • Photodiagnosis and Photodynamic Therapy (2026)

Purpose: This study used wide-field swept-source optical coherence tomography angiography (WF-SS-OCTA) to evaluate changes in macular vascular density in patients with obstructive sleep apnea syndrome (OSAS) at different stages of disease d...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.pdpdt.2026.105582

Ultra-Bend-Resistant 4-Core Simplex Cable Used for Short-Reach Dense Spatial Division Multiplexing Optical Transmission

Zelin Zhang, Yu Qin, Jie Zhu, Caoyuan Wang et al. • Micromachines (2024)

We optimized and fabricated an ultra-bend-resistant 4-core simplex cable (SXC) employing 4-core multicore fiber (MCF) suitable for short-reach dense spatial division multiplexing (DSDM) optical transmission in the O-band. The characteristic...

DOAJ Open Access (DOAJ) DOI: 10.3390/mi15010108

Imaging with Diffractive Axicons Rapidly Milled on Sapphire by Femtosecond Laser Ablation

Daniel Smith, Soon Hock Ng, Molong Han, Tomas Katkus et al. • Engineering Proceedings (2023)

We show that single-pulse burst fabrication will produce a flatter and smoother profile of axicons milled on sapphire compared to pulse overlapped fabrication which results in a damaged and much rougher surface. The fabrication of large-are...

DOAJ Open Access (DOAJ) DOI: 10.3390/HMAM2-14147

Compositional tuning of structural, photothermal and optical properties of La-based high-entropy perovskite oxides

Anurag Khandelwal, Piyush Anil Kumar Sharma, Simon Schweidler, Pirmin Tischler et al. • Materials & Design (2026)

In this study, 14 lanthanum-based high-entropy perovskite oxides (HEPOs) with equimolar mixtures of transition metals (Cr, Mn, Fe, Co, Ni, Cu, Zn) at the B-site were synthesized to investigate how multi-elemental interactions govern their s...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.matdes.2026.116517