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A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer

Sneha Pallatt, Sibin Nambidi, Subhamay Adhikary, Antara Banerjee et al. • Oncology Reviews (2025)

Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. These mutations result in frameshift alterations, leading to the accumulation of errors within microsatellites. Individua...

DOAJ Open Access (DOAJ) DOI: 10.3389/or.2025.1549416

Emerging mutations in envelope protein of SARS-CoV-2 and their effect on thermodynamic properties

Kejie Mou, Mohnad Abdalla, Dong Qing Wei, Muhammad Tahir Khan et al. • Informatics in Medicine Unlocked (2021)

Structural proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are potential drug targets due to their role in the virus life cycle. The envelope (E) protein is one of the structural proteins; plays a critical role in v...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.imu.2021.100675

Molecular Characterization of Cryptosporidium Species in Children with Diarrhea in North West of Iran

Behroz Mahdavi poor, Mohammad Asgharzadeh, Esmaeel Fallah, Kareem Hatam-Nahavandi et al. • International Journal of Molecular and Cellular Medicine (2015)

Cryptosporidium is one of the most common causes of childhood diarrhea in developing countries. The aim of this randomized pilot study was to detect and characterize infective species and determine the genotypes of Cryptosporidium parasites...

DOAJ Open Access (DOAJ)

Persistent Endothelial Dysfunction in Post-Acute COVID-19 Syndrome: A Case-Control Study

Pasquale Ambrosino, Ilenia Calcaterra, Antonio Molino, Pasquale Moretta et al. • Biomedicines (2021)

Background: Endothelial dysfunction has a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its disabling complications. We designed a case-control study to assess the alterations of endothelium-dependent flow-mediated...

DOAJ Open Access (DOAJ) DOI: 10.3390/biomedicines9080957

Calliphoridae Flies in Medical Biotechnology

A. Yu. Yakovlev, Anastasia A. Kruglikova, Sergey I. Chernysh • Entomological Review (2019)

Blow flies (Diptera, Calliphoridae) and their medical applications have attracted the attention of biologists and doctors for more than a century. The best known is the use of “surgical maggots” in the treatment of infected wounds and ulcer...

OPENALEX DOI: https://doi.org/10.1134/s0013873819030023

Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

Sarah L. Baines, Kathryn E. Holt, Mark B. Schultz, Torsten Seemann et al. • mBio (2015)

ABSTRACT Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persiste...

DOAJ Open Access (DOAJ) DOI: 10.1128/mBio.00080-15

Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice

Raife Dilek Turan, Cihan Tastan, Derya Dilek Kancagi, Bulut Yurtsever et al. • Scientific Reports (2021)

Abstract The SARS-CoV-2 virus caused the most severe pandemic around the world, and vaccine development for urgent use became a crucial issue. Inactivated virus formulated vaccines such as Hepatitis A and smallpox proved to be reliable appr...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-021-95086-4

High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa

Yan Yang, Xue Li, Lang Sun, Xiu-Kun Wang et al. • Microbiology Spectrum (2025)

ABSTRACT Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in mex...

DOAJ Open Access (DOAJ) DOI: 10.1128/spectrum.01398-24

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Chih-Yang Huang, Chia-Hua Kuo, Pei-Ying Pai, Tsung-Jung Ho et al. • Data in Brief (2018)

In association with the published article “Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy” (Huang et al., 2017) [1], this data article contains information about deSUMOylat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dib.2017.11.040

SIRT1 and miR-34a as Potential Plasma Biomarkers in the Acute Phase of Ischemic Stroke

Mitra Ansari, Moslem Esmati, Seyed khalil Rashidi, Shahram Rafie et al. • International Journal of Molecular and Cellular Medicine (2025)

Stroke is the major cause of disability and mortality worldwide. Identification of molecular biomarkers in the early hours after stroke is important in terms of both diagnostic and therapeutic applications. miR-34a, a highly expressed miRNA...

DOAJ Open Access (DOAJ)

Antibody response after pneumococcal vaccination in a large cohort of Italian children and adolescents with Down syndrome

Antonio Musolino, Marco Roversi, Mariateresa Romaniello, Vittorio Scoppola et al. • Vaccine: X (2025)

Introduction: Pneumococcal vaccination has significantly decreased the burden of invasive pneumococcal disease in the general population, however studies on effectiveness in Down syndrome (DS) are heterogeneous. In this cross-sectional stud...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jvacx.2025.100744

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou et al. • Scientific Reports (2023)

Abstract Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, espec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-023-27720-2

Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms

Xiao Wang, Wenxuan Shi, Yu Jin, Zhuoyuan Li et al. • Journal of Nanobiotechnology (2025)

Abstract The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03126-2

Reimbursement Legislations and Decision Making for Orphan Drugs in Central and Eastern European Countries

Krzysztof Piotr Malinowski, Paweł Kawalec, Wojciech Trąbka, Marcin Czech et al. • Frontiers in Pharmacology (2019)

BackgroundReimbursement policies influence access of patients to orphan drugs in the European countries.ObjectivesTo provide a comprehensive description of orphan drug reimbursement policies and to assess reimbursement decision-making proce...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2019.00487

Epstein–Barr Virus-Induced Metabolic Rearrangements in Human B-Cell Lymphomas

Pier P. Piccaluga, Pier P. Piccaluga, Pier P. Piccaluga, Alessandra Weber et al. • Frontiers in Microbiology (2018)

Tumor metabolism has been the object of several studies in the past, leading to the pivotal observation of a consistent shift toward aerobic glycolysis (so-called Warburg effect). More recently, several additional investigations proved that...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2018.01233

Deregulated miRNA clusters in ovarian cancer: Imperative implications in personalized medicine

Amoolya Kandettu, Divya Adiga, Vasudha Devi, Padmanaban S. Suresh et al. • Genes and Diseases (2022)

Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC is usually detected at the advanced stages of the disease, making it highly lethal. miRNAs are single-stranded, small non-coding RNAs with an approxim...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.gendis.2021.12.026

Prevalence of Obesity and Malnutrition among School-Aged Children of the District Peshawar

Usman Shah1, Usman Saeed2, Maryam Bibi3,, , Shakir Ullah3 et al. • Egyptian Journal of Nutrition (2024)

ABSTRACTMalnutrition and Obesity are worldwide health phenomena so the aims of the study were to assist the prevalence of obesity and malnutrition among school-aged children of the district Peshawar. Institutional based cross-sectional stud...

DOAJ Open Access (DOAJ) DOI: 10.21608/enj.2024.391626