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Showing 20 of 554 academic articles

Evaluation of microhardness of residual dentin in primary molars following caries removal with conventional and chemomechanical techniques: An In vitro Study

A Shihab Anwar, R Krishna Kumar, V Arun Prasad Rao, N Venugopal Reddy et al. • Journal of Pharmacy and Bioallied Sciences (2017)

Background: Many patients consider removal of caries to be a very unpleasant experience. Removal of caries with conventional drill is considered traumatic mainly due to fear and anxiety of children and their parents. Minimally invasive dent...

DOAJ Open Access (DOAJ) DOI: 10.4103/jpbs.JPBS_148_17

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V Variants

Khushboo Singh, Roon Banerjee, Chandrakanta Potdar, Anisha Shaw et al. • Cells (2026)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson’s disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 di...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells15040342

Effects of the Brazilian Native Fruit Jaboticaba (<i>Plinia cauliflora</i>) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models

Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino et al. • Foods (2025)

Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory an...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14234030

miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4

Jinyu Liu, Xiaowei Yuan, Wei Chen, Dongqin Shen • Clinical and Applied Thrombosis/Hemostasis (2026)

Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis dia...

DOAJ Open Access (DOAJ) DOI: 10.1177/10760296261468449

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Brianna Dufek, Daniel T Meehan, Duane Delimont, Kevin Wilhelm et al. • PLoS ONE (2020)

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels o...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0237907

Sequential Portal Vein Embolization and Percutaneous Radiofrequency Ablation for Future Liver Remnant Growth: A Minimally Invasive Alternative to ALPPS Stage-1 in Treatment of Hepatocellular Carcinoma

Qiang Wang, Qiang Wang, Yujun Ji, Torkel B. Brismar et al. • Frontiers in Surgery (2021)

Background: To evaluate the feasibility and efficacy of sequential portal vein embolization (PVE) and radiofrequency ablation (RFA) (PVE+RFA) as a minimally invasive variant for associating liver partition and portal vein ligation for stage...

DOAJ Open Access (DOAJ) DOI: 10.3389/fsurg.2021.741352

Impact of Myocardial Ischemia and Revascularization by Percutaneous Coronary Intervention on Circulating Level of Soluble ST2

Alkhateeb A, Mahmoud HEM, AK M, Hassan MH et al. • Vascular Health and Risk Management (2023)

Areej Alkhateeb,1 Hossam Eldin M Mahmoud,1 Mohammed AK,1 Mohammed H Hassan,2 Abdel Rahim Mahmoud Muddathir,3 Ahmed G Bakry1 1Cardiology Division of Internal Medicine Department, South Valley University Hospital, Faculty of Medicine, South V...

DOAJ Open Access (DOAJ)

Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study

Chung-woo Lee, Joo Kyung Lee, Yeon Joo Choi, Hyunjin Kim et al. • Scientific Reports (2022)

Abstract Revascularization procedures, including percutaneous coronary intervention (PCI), for coronary artery disease (CAD) are increasingly performed in Korea. However, studies on blood pressure control targets in these patients remain in...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-022-06627-4

Evaluating key predictors of breast cancer through survival: a comparison of AFT frailty models with LASSO, ridge, and elastic net regularization

Senyefia Bosson-Amedenu, Emmanuel Ayitey, Francis Ayiah-Mensah, Luyton Asare • BMC Cancer (2025)

Abstract Background Frailty models are extensively utilized in survival analysis to address unobserved heterogeneity among individuals. However, selecting the most robust model for survival prediction, especially in the context of high-dime...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12885-025-14040-z

Modeling antiretroviral therapy adherence among people living with HIV: a cross-sectional study at Pantang Hospital, Ghana

Eric Nyarko, Irene A. Kretchy, Grace Lovia Allotey-Babington, Adwoa Oforiwaa Kwakye et al. • BMC Infectious Diseases (2026)

Abstract Background Poor adherence to antiretroviral therapy (ART) continues to undermine HIV treatment outcomes in sub-Saharan Africa, including Ghana. Objective This study aimed to quantify ART treatment adherence among people living with...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12879-026-13836-z

Mathematical Modeling of Leptospirosis With Misdiagnosis

Japheth Musingila Mwongela, Caroline Kanyiri, Virginia Kitetu • Journal of Applied Mathematics (2026)

Leptospirosis is a widespread zoonotic bacterial disease that continues to pose a major public health challenge, particularly in developing countries where it causes substantial morbidity, mortality, and economic losses. A key problem in co...

DOAJ Open Access (DOAJ) DOI: 10.1155/jama/5513951

Increased prevalence of loneliness and associated risk factors during the COVID-19 pandemic: findings from the Canadian Longitudinal Study on Aging (CLSA)

Susan A. Kirkland, Lauren E. Griffith, Urun Erbas Oz, Mary Thompson et al. • BMC Public Health (2023)

Abstract Background Older adults have been disproportionately impacted by COVID-19 and related preventative measures undertaken during the pandemic. Given clear evidence of the relationship between loneliness and health outcomes, it is impe...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12889-023-15807-4

Predicting the distribution and habitat suitability of the smooth-coated otter (Lutrogale perspicillata) in lowland Nepal

Paras Mani Acharya, Panu Thainiramit, Kuaanan Techato, Suraj Baral et al. • Global Ecology and Conservation (2023)

Ever increasing anthropogenic pressures and natural threats to freshwater ecosystems are impacting global biodiversity. Otters are an indicator species that have an important role in maintaining the integrity and stability of wetland ecosys...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.gecco.2023.e02578

Implementation of the therapeutic use of hydroxyurea for sickle cell disease management in resource-constrained settings: a systematic review of adoption, cost and acceptability

Joyce Gyamfi, Temitope Ojo, Dorice Vieira, Nessa Ryan et al. • BMJ Open (2020)

Objectives Mortality associated with sickle cell disease (SCD) is high in many low- and middle-income countries (LMICs). Hydroxyurea, a medicine to effectively manage SCD, is not widely available in resource-constrained settings. We identif...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2020-038685

Traffic Fatalities and Urban Infrastructure: A Spatial Variability Study Using Geographically Weighted Poisson Regression Applied in Cali (Colombia)

Harvy Vivas Pacheco, Diego Rodríguez-Mariaca, Ciro Jaramillo, Andrés Fandiño-Losada et al. • Safety (2023)

The mobility plan and the road infrastructure works implemented, together with the Bus Rapid Transit (BRT) connected bus system in its first two phases, generated optimistic expectations about the reduction of lethal crashes in the city. Th...

DOAJ Open Access (DOAJ) DOI: 10.3390/safety9020034

Designing tax incentives and disincentives for urban cultural heritage conservation: a behavioral policy framework

Zijian Yao • Journal of Asian Architecture and Building Engineering (2026)

This study proposes a systematic policy framework that leverages special tax measures to steer stakeholder behavior toward urban cultural heritage conservation. Integrating comparative policy analysis, microeconomic modeling, systematic pol...

DOAJ Open Access (DOAJ) DOI: 10.1080/13467581.2026.2639088

Evaluating the impact of urban traffic patterns on air pollution emissions in Dublin: a regression model using google project air view data and traffic data

Pavlos Tafidis, Mehdi Gholamnia, Payam Sajadi, Sruthi Krishnan Vijayakrishnan et al. • European Transport Research Review (2024)

Abstract Air pollution is a significant and pressing environmental and public health concern in urban areas, primarily driven by road transport. By gaining a deeper understanding of how traffic dynamics influence air pollution, policymakers...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12544-024-00671-z

The influence of roadway characteristics and built environment on the extent of over-speeding: An exploration using mobile automated traffic camera data

Boniphace Kutela, Frank Ngeni, Cuthbert Ruseruka, Tumlumbe Juliana Chengula et al. • International Journal of Transportation Science and Technology (2025)

Over-speeding is a pivotal factor in fatal traffic crashes globally, necessitating robust speed management strategies to augment road safety. In 2021, the National Highway Traffic Safety Administration reported over 12 000 speed-related fat...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ijtst.2024.03.003