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Fractional exhaled nitric oxide as a potential biomarker for radiation pneumonitis in patients with non-small cell lung cancer: A pilot study

W.M. Szejniuk, M.S. Nielsen, D. Brønnum, Z. Takács-Szabó et al. • Clinical and Translational Radiation Oncology (2019)

Introduction: The aim of the study was to investigate repetitive fractional exhaled nitric oxide (FeNO) measurements during high-dose radiation therapy (HDRT) and to evaluate the use of FeNO to predict symptomatic radiation pneumonitis (RP)...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.ctro.2019.09.004

Digital health technologies and major depressive disorder

Roger S. McIntyre, Walter Greenleaf, Grzegorz W. Bulaj, Steven T. Taylor et al. • CNS Spectrums (2023)

There is an urgent need to improve the clinical management of major depressive disorder (MDD), which has become increasingly prevalent over the past two decades. Several gaps and challenges in the awareness, detection, treatment, and monito...

OPENALEX cc-by-nc DOI: https://doi.org/10.1017/s1092852923002225

Digital biomarkers: Convergence of digital health technologies and biomarkers

Srikanth Vasudevan, Anindita Saha, Michelle E. Tarver, Bakul Patel • npj Digital Medicine (2022)

Over the last decade, increasing digitization across the healthcare continuum has revolutionized medical research, diagnostics, and therapeutics. This digitization has led to rapid advancements in the development and adoption of digital hea...

OPENALEX cc-by DOI: https://doi.org/10.1038/s41746-022-00583-z PMC: 8956713

Predictive Value of Serum Cytokeratin 19 Level for the Feasibility of Conserving Ovaries in Endometrial Cancer

Jie Xu, Jie Xu, Can Chen, Can Chen et al. • Frontiers in Medicine (2021)

Objective: To determine the predictive value of cytokeratin 19 (CK19) for evaluating the safety of ovarian preservation in patients with endometrial cancer (EC).Methods: Five hundred and seventeen EC patients hospitalized from November 2010...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmed.2021.670109

Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers

Cayetano Javier Carrión-García, Eduardo Jesús Guerra-Hernández, Belén García-Villanova, Mauro Serafini et al. • Antioxidants (2020)

(1) Background: Little is known about the interlinkages between dietary and plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body’s antioxidant and inflammation response. Our aim was to explore these assoc...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox9040301

Mapping the acute trajectory of sport-related concussion outcomes across symptoms, cognition, and blood biomarkers

SoYoung Ahn, Michael Prock, Ji-won Seo, Sanghyuk Han et al. • Sports Medicine and Health Science (2026)

Sport-related concussion (SRC) and its potential neurological sequela represent an emerging global health concern, requiring improved recovery management and strategies for return-to-play (RTP) to enhance brain health in athletes. Given the...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.smhs.2025.07.003

Serum amyloid beta 42 levels correlated with metabolic syndrome and its components

Kecheng Li, Kecheng Li, Xiaoli Zhou, Xiaoli Zhou et al. • Frontiers in Endocrinology (2024)

IntroductionBeta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer’s disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-β pe...

DOAJ Open Access (DOAJ) DOI: 10.3389/fendo.2024.1278477

Advances in High Throughput Proteomics Profiling in Establishing Potential Biomarkers for Gastrointestinal Cancer

Md Zahirul Islam Khan, Shing Yau Tam, Helen Ka Wai Law • Cells (2022)

Gastrointestinal cancers (GICs) remain the most diagnosed cancers and accounted for the highest cancer-related death globally. The prognosis and treatment outcomes of many GICs are poor because most of the cases are diagnosed in advanced me...

DOAJ Open Access (DOAJ) DOI: 10.3390/cells11060973

Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau

Lauren E. McCollum, Sandhitsu R. Das, Long Xie, Robin de Flores et al. • NeuroImage: Clinical (2021)

Mild cognitive impairment (MCI) can be an early manifestation of Alzheimer’s disease (AD) pathology, other pathologic entities [e.g., cerebrovascular disease, Lewy body disease, LATE (limbic-predominant age-related TDP-43 encephalopathy)], ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2021.102717

Association of androgen receptor and tumour-infiltrating lymphocytes with bone recurrence in triple-negative breast cancer

Petra Ilenič, Ajda Herman, Erik Langerholc, Barbara Gazić et al. • Journal of Bone Oncology (2024)

Background: As compared to endocrine responsive breast cancer bone is less frequent site of distant recurrence in triple-negative breast cancer (TNBC). A biomarker which predicts bone recurrence would allow a more personalized treatment app...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jbo.2023.100518

Identification of brain regions predicting epileptogenesis by serial [18F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy

Vera Russmann, Matthias Brendel, Erik Mille, Angela Helm-Vicidomini et al. • NeuroImage: Clinical (2017)

Excessive activation of inflammatory signaling pathways seems to be a hallmark of epileptogenesis. Positron emission tomography (PET) allows in vivo detection of brain inflammation with spatial information and opportunities for longitudinal...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2017.04.003

Early Retinal Microvascular Alterations in Young Type 1 Diabetic Patients without Clinical Retinopathy

Alexandra Oltea Dan, Alin Ștefănescu-Dima, Andrei Teodor Bălășoiu, Ileana Puiu et al. • Diagnostics (2023)

The purpose of this study is to identify and quantify preclinical changes with the help of optical coherence tomography angiography (OCTA) within the retinal microcirculation of young type 1 diabetes (T1D) patients without clinical signs of...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics13091648

From Connectivity to Controllability: Unraveling the Brain Biomarkers of Major Depressive Disorder

Chunyu Pan, Ying Ma, Lifei Wang, Yan Zhang et al. • Brain Sciences (2024)

Major Depressive Disorder (MDD) is a significant neurological condition associated with aberrations in brain functional networks. Traditional studies have predominantly analyzed these from a network topology perspective. However, given the ...

DOAJ Open Access (DOAJ) DOI: 10.3390/brainsci14050509

A real-world clinical validation for AI-based MRI monitoring in multiple sclerosis

Michael Barnett, Dongang Wang, Heidi Beadnall, Antje Bischof et al. • npj Digital Medicine (2023)

Abstract Modern management of MS targets No Evidence of Disease Activity (NEDA): no clinical relapses, no magnetic resonance imaging (MRI) disease activity and no disability worsening. While MRI is the principal tool available to neurologis...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41746-023-00940-6

Central vein sign: A diagnostic biomarker in multiple sclerosis (CAVS-MS) study protocol for a prospective multicenter trial

D. Ontaneda, P. Sati, P. Raza, M. Kilbane et al. • NeuroImage: Clinical (2021)

The specificity and implementation of current MRI-based diagnostic criteria for multiple sclerosis (MS) are imperfect. Approximately 1 in 5 of individuals diagnosed with MS are eventually determined not to have the disease, with overrelianc...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2021.102834

Grey matter volume associations with personality functioning in a clinical cohort of female youths

Madelyn Thomson, Marialuisa Cavelti, Ines Mürner-Lavanchy, Silvano Sele et al. • NeuroImage: Clinical (2026)

Borderline Personality Disorder (BPD) is a severe mental illness, although its neurobiological underpinnings remain largely unknown. Structural Magnetic Resonance Imaging (sMRI) in adolescents can offer insights into potential biomarkers to...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2026.103988

Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders

Ya Chai, José R. Chimelis-Santiago, Kristy A. Bixler, Matthew Aalsma et al. • NeuroImage: Clinical (2021)

Background: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fr...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.nicl.2021.102789

Computational Tools; Indispensable Armamentarium of Medical Biotechnology

Nutan, Swapnil Jain, K Shilpa, Akanksha Tomar et al. • Indian Journal of Science and Technology (2016)

Objective: Computational infrastructure of medical biotechnology provides insight into elements of genomics, proteomics for understanding diseases and biological systems in a more comprehensive and systematic way. The present study exclusiv...

OPENALEX cc-by DOI: https://doi.org/10.17485/ijst/2016/v9i32/100745

SIRT1 and miR-34a as Potential Plasma Biomarkers in the Acute Phase of Ischemic Stroke

Mitra Ansari, Moslem Esmati, Seyed khalil Rashidi, Shahram Rafie et al. • International Journal of Molecular and Cellular Medicine (2025)

Stroke is the major cause of disability and mortality worldwide. Identification of molecular biomarkers in the early hours after stroke is important in terms of both diagnostic and therapeutic applications. miR-34a, a highly expressed miRNA...

DOAJ Open Access (DOAJ)