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Vesicular Carriers for Phytochemical Delivery: A Comprehensive Review of Techniques and Applications

Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Rekha Rao et al. • Pharmaceutics (2025)

Natural substances, especially those derived from plants, exhibit a diverse range of therapeutic benefits, such as antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Nevertheless, their use in clinical settings is freque...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics17040464

Berberine protects against hypoxia-induced intestinal injury through modulation of gut microbiota and bile acid metabolism

Hao Zhang, Hao Zhang, Hao Zhang, Penghui Ye et al. • Frontiers in Immunology (2026)

BackgroundHigh-altitude hypoxia disrupts intestinal homeostasis by impairing the epithelial barrier, triggering inflammation, and promoting microbial translocation. Berberine (BER), a natural isoquinoline alkaloid with antimicrobial and ant...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2026.1784245

A hybrid plasmid formed by recombination of a virulence plasmid and a resistance plasmid in Klebsiella pneumoniae

Miaomiao Xie, Ning Dong, Kaichao Chen, Xuemei Yang et al. • Journal of Global Antimicrobial Resistance (2020)

Objective: The emergence of multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae (hvKP) facilitates simultaneous dissemination of virulence and resistance in a single event, which poses serious threat to public health. Methods:...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jgar.2020.10.018

Antimicrobial compound from Trichoderma harzianum, an endophytic fungus associated with ginger (Zingiber officinale)

Harwoko Harwoko, Jungho Lee, Georgios Daletos, Michael Feldbrügge et al. • JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) (2021)

Background: Genus Trichoderma of fungal kingdom are largely used as biological control agents due to broad-spectrum activity against plant pathogens. Objective: This study aimed to investigate Trichoderma harzianum, an endophytic fungus obt...

DOAJ Open Access (DOAJ) DOI: 10.20885/JKKI.Vol12.Iss2.art8

Combination of Antimicrobial Starters for Feed Fermentation: Influence on Piglet Feces Microbiota and Health and Growth Performance, Including Mycotoxin Biotransformation in vivo

Laurynas Vadopalas, Modestas Ruzauskas, Modestas Ruzauskas, Vita Lele et al. • Frontiers in Veterinary Science (2020)

The aim of this study was to apply a combination of the microbial starters Lactobacillus uvarum LUHS245, Lactobacillus casei LUHS210, Pediococcus acidilactici LUHS29, and Pediococcus pentosaceus LUHS183 for feed fermentation and to evaluate...

DOAJ Open Access (DOAJ) DOI: 10.3389/fvets.2020.528990

Purification, Characterization and Bactericidal Action of Lysozyme, Isolated from <i>Bacillus subtillis</i> BSN314: A Disintegrating Effect of Lysozyme on Gram-Positive and Gram-Negative Bacteria

Muhammad Naveed, Yadong Wang, Xian Yin, Malik Wajid Hussain Chan et al. • Molecules (2023)

In the present study, lysozyme was purified by the following multi-step methodology: salt (ammonium sulfate) precipitation, dialysis, and ultrafiltration. The lysozyme potential was measured by enzymatic activity after each purification ste...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules28031058

Effectiveness of an electronic clinical decision support system in improving the management of childhood illness in primary care in rural Nigeria: an observational study

Marek Kwiatkowski, Rodolfo Rossi, Torsten Schmitz, Fenella Beynon et al. • BMJ Open (2022)

Objectives To evaluate the impact of ALgorithm for the MANAgement of CHildhood illness (‘ALMANACH’), a digital clinical decision support system (CDSS) based on the Integrated Management of Childhood Illness, on health and quality of care ou...

DOAJ Open Access (DOAJ) DOI: 10.1136/bmjopen-2021-055315

Storage Properties of Double-Layer Films Enriched with <i>Phytolacca americana</i> L. Extract as Active Packaging for African Catfish, with a New Approach to Antioxidant Film Assay and Additional Analysis of <i>P. americana</i> Extract Toxicity on Human Cell Lines

Joanna Maria Jasińska, Klaudia Michalska, Joanna Tkaczewska, Katarzyna Tkacz et al. • Molecules (2025)

Novel double-layer films based on furcellaran (FUR) and gelatin (GEL) with the addition of Phytolacca americana L. (PA) extract were used as active packaging for African catfish fillets. Films with PA extract have been shown to minimize the...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules30071447

Calliphoridae Flies in Medical Biotechnology

A. Yu. Yakovlev, Anastasia A. Kruglikova, Sergey I. Chernysh • Entomological Review (2019)

Blow flies (Diptera, Calliphoridae) and their medical applications have attracted the attention of biologists and doctors for more than a century. The best known is the use of “surgical maggots” in the treatment of infected wounds and ulcer...

OPENALEX DOI: https://doi.org/10.1134/s0013873819030023

Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

Sarah L. Baines, Kathryn E. Holt, Mark B. Schultz, Torsten Seemann et al. • mBio (2015)

ABSTRACT Infections caused by highly successful clones of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) are a major public health burden. The globally dominant sequence type 239 (ST239) HA-MRSA clone has persiste...

DOAJ Open Access (DOAJ) DOI: 10.1128/mBio.00080-15

Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels

Saidakhon T. Islamova, Moxira A. Nazarova, Aktam U. Burkhanov, Fayzulla Khamraev et al. • Caspian Journal of Environmental Sciences (2025)

The growing recognition of the health-promoting potential of compounds derived from natural sources, particularly those exhibiting antimicrobial and antioxidant activities, has resulted in a surge of research publications dedicated to explo...

DOAJ Open Access (DOAJ) DOI: 10.22124/cjes.2025.8570

High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa

Yan Yang, Xue Li, Lang Sun, Xiu-Kun Wang et al. • Microbiology Spectrum (2025)

ABSTRACT Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in mex...

DOAJ Open Access (DOAJ) DOI: 10.1128/spectrum.01398-24

The antibiogram of Pus cultures in Federal Tertiary Care Hospital, Islamabad and its utility in antimicrobial stewardshipThe antibiogram of pus cultures in federal tertiary care hospital, Islamabad and its utility in antimicrobial stewardship

Farhan Kursheed, Asraar Tabassum, Umme Farwa, Samia Wazir et al. • Iranian Journal of Microbiology (2024)

Background and Objectives: Antimicrobial resistance has emerged as a significant global health threat. Infections caused by Multi Drug-Resistant (MDR) bacteria pose formidable challenges in terms of treatment options and patient outcomes. P...

DOAJ Open Access (DOAJ) DOI: 10.18502/ijm.v16i1.14871

Comparative Phytochemical Analysis of the Aerial Parts of <i>Pelargonium radula</i> and <i>Geranium macrorrhizum</i> Cultivated in Bulgaria Using GC-MS and HPLC

Debora Sabotinova, Petya Boycheva, Nadezhda Ivanova, Velichka Andonova et al. • Pharmaceuticals (2026)

Background: Geraniaceae species are widely used in traditional medicine. Pelargonium radula and Geranium macrorrhizum are aromatic medicinal plants traditionally used in Bulgaria for their antimicrobial, anti-inflammatory, and wound-healing...

DOAJ Open Access (DOAJ) DOI: 10.3390/ph19030346

Medical Biotechnology 2020

Magnus Magnusson • Journal of Antimicrobial Agents (2021)

In recent years, the field of medical biotechnology has experienced rapid growth, leading to the development of several innovative techniques for disease prevention, diagnosis and treatment. New methodologies, including polymerase chain rea...

OPENALEX

Regulatory requirements for the registration of generic medicines and format of drug dossiers: procedures in Sri Lanka in comparison with selected regulatory authorities

D. Thambavita, P. Galappatthy, R. L. Jayakody • Journal of Pharmaceutical Policy and Practice (2018)

Background The regulatory requirements for approval of generic medicines and the format of compiling drug dossiers vary among regulatory authorities. The variation is particularly wide between High-income countries (HIC) and lower and middl...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40545-018-0141-2

Burden of five healthcare associated infections in Australia

M. J. Lydeamore, B. G. Mitchell, T. Bucknall, A. C. Cheng et al. • Antimicrobial Resistance and Infection Control (2022)

Abstract Background Healthcare associated infections are of significant burden in Australia and globally. Previous estimates in Australia have relied on single-site studies, or combinations thereof, which have suggested the burden of these ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13756-022-01109-8

A Novel Peptide Antibiotic Produced by Streptomyces roseoflavus Strain INA-Ac-5812 With Directed Activity Against Gram-Positive Bacteria

Alexey S. Vasilchenko, William T. Julian, Olda A. Lapchinskaya, Genrikh S. Katrukha et al. • Frontiers in Microbiology (2020)

In this work, we report the isolation and detailed functional characterization for the new non-ribosomally synthesized antibiotic 5812-A/C, which was derived from metabolites of Streptomyces roseoflavus INA-Ac-5812. According to its chemica...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2020.556063

Antibiogram Profile and Resistance Patterns of Microflora from Vaginal Discharge in Reproductive-age Women at a Nigerian Teaching Hospital

Chizoba M. Enemchukwu, Christiana Nwabueze, Oluchi J. Osuala, Chinedu J. Ikem et al. • RADS Journal of Biological Research & Applied Science (2024)

Background: The adult human vagina hosts a complex biota containing diverse communities of microorganisms. The occurrence of multi-drug-resistant strains of these microorganisms has persistently increased due to poor hygiene and misuse or a...

DOAJ Open Access (DOAJ)